Studies on the genotoxic effect of beryllium chloride and the possible protective role of selenium/vitamins A, C and E

Fahmy, Maha A.; Hassan, Neveen A.; Farghaly, Ayman A.; Hassan, Entesar E.

doi:10.1016/j.mrgentox.2007.12.009

Cited by 22 publications

(12 citation statements)

References 54 publications

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“…A significant inrease in PLT counts was found in the furan treated group. Chemicals can induce histopathological damages (27) and these damages can stir up an increase in PLT and WBC counts (22). Our histopathological results support this probability in the furan treated group.…”

Section: Discussionsupporting

confidence: 78%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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Furan forms as a result of thermal treatment of food and induces harmful effects on organisms. In our work, lycopene, furan, and a combination of the two were given to diabetic male rats for 28 days. Hematological changes, total protein and cholesterol, triglyceride, and albumin levels, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase activities of the serum, malondialdehyde levels, glutathione peroxidase, catalase, glutathione-S-transferase, superoxide dismutase activities, DNA damage in liver tissues and hepatic histopathological alterations were compared to a control group. There were significant changes in the liver function tests, DNA damage, activities of antioxidant enzymes, and malondialdehyde levels between diabetic control and non-diabetic control groups, between diabetic control and diabetic lycopene groups, and also between diabetic furan and diabetic control groups. In diabetic lycopene and diabetic furan + lycopene treated groups we designated the preventive effects of lycopene against diabetes and furan, however, on the analysed parameters only. In spite of some pathological alterations designated in diabetic furan treated group's liver, fewer pathological alterations were observed in furan+lycopene treated groups at the end of week 4. Consequently, lycopene significantly reduced furan-and diabetes-induced toxicity in rat liver.

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Section: Discussionsupporting

confidence: 78%

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Baş

Pandır

Kalender

2016

Archives of Industrial Hygiene and Toxicology

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“…Zinc and selenium stimulate the expression of DNA repair factors. Further, zinc facilitates the synthesis of nucleic acids; promotes replication of cells, and gene expression [49], which could attribute to the protective response. As selenocysteine residues form an important component of the enzyme glutathione peroxidase, we presume that the presence of selenium in the combination played a role in averting micronuclei formation.…”

Section: Discussionmentioning

confidence: 99%

“…Our results are in accordance with several findings depicting the protective response exerted by selenium against cellular and sub-cellular damage. Reports suggest that selenium in combination with vitamins administered for varying periods of time can minimize beryllium chloride induced chromosomal abnormalities in bone marrow of mice [49]. Preneoplastic and neoplastic lesions in rat liver were reduced on supplementation of diet with sodium selenite (5 g/ml/100 g) for periods ranging from 1 day to several weeks [50].…”

Section: Discussionmentioning

confidence: 99%

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Banji¹,

Banji²,

Reddy³

et al. 2013

Journal of Trace Elements in Medicine and Biology

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“…Besides exerting antioxidant influence directly, VC can promote the repair of oxidative DNA damage from the DNA and/or nucleotide pool, through upregulation of repair enzymes (Cooke et al, 1998). The inhibitory effect of VC towards a number of mutagens/ carcinogens was shown by many authors in humans and animals (Fahmy et al, 2008;Hassan et al, 2006;Mooney et al, 2005). Many people have worked on the protective effect of VC, but no one has determined the optimum level at which VC exerts its maximum protection against the genotoxicity of iron.…”

mentioning

confidence: 99%

Iron induced genotoxicity: attenuation by vitamin C and its optimization

Parveen

Ahmad

Shadab

2014

Interdisciplinary Toxicology

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Vitamin C (VC) is a well-known antioxidant and strong free radical scavenger. Its antioxidant activity is useful for protection of cellular macromolecules, particularly DNA, from oxidative damage induced by different agents. This study was undertaken to evaluate the optimum level of VC in attenuating the chromosome aberrations (CAs) and DNA damage after iron sulfate (FeSO 4 ) acute administration in Wistar rats. The results exhibited that the increase of CAs and DNA damage induced by FeSO 4 , 200 mg Fe/kg, could be reduced significantly by VC pretreatment at the dose of 500 mg/kg (p<0.001), but not in the 100 mg/kg group. The findings provide evidence that VC at the dose of 500 mg/kg exerted a possible protective effect against FeSO 4 induced CAs and DNA damage. The possible mechanisms of VC may be attributed to its property as a free radical scavenger or to its indirect action in reducing the level of reactive oxygen species (ROS).

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Studies on the genotoxic effect of beryllium chloride and the possible protective role of selenium/vitamins A, C and E

Cited by 22 publications

References 54 publications

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Furan-induced hepatotoxic and hematologic changes in diabetic rats: the protective role of lycopene

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Iron induced genotoxicity: attenuation by vitamin C and its optimization

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