Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction

Mungantiwar, Ashish; Nair, Anupama; Shinde, Ujwala A.; Dikshit, V.J; Saraf, M. N.; Thakur, Vikas; Sainis, Krishna B.

doi:10.1016/s0378-8741(98)00153-6

Cited by 72 publications

(39 citation statements)

References 4 publications

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“…However, the inhibition was observed only during post-immunization drug treatment, while no effect during pre-immunization drug treatment was observed. [65] Antistress & adoptogenic Activity…”

Section: Immunomodulatory Effectsmentioning

confidence: 99%

Punarnava (Boerhaavia Diffusa Linn.): A Comprehensive Review

Pratibha¹

2017

WJPPS

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Section: Immunomodulatory Effectsmentioning

confidence: 99%

Punarnava (Boerhaavia Diffusa Linn.): A Comprehensive Review

Pratibha¹

2017

WJPPS

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“…Previous reports suggested that agents that induce increases in hemagglutinin antibody titers act as immunostimulatory agents and that several Indian medicinal plants have immunostimulatory activity. [17][18][19][20][21] Significant changes were not observed in body weight gain, total RBC counts, 9.92 ± 0.22 n = 6 mice in each group, data expressed as mean ± S.E.M. p < 0.05, Student's t test (vehicle control vs. treatment).…”

Section: Immunopotentiating Effects Of Cim-candymentioning

confidence: 99%

Immunopotentiating Effect of an Ayurvedic Preparation from Medicinal Plants

Bawankule

Mani

Pal

et al. 2009

JOURNAL OF HEALTH SCIENCE

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A formulation of Ocimum sanctum, Phyllanthus emblica, and Glycyrrhiza glabra in a defined ratio termed CIM-Candy was prepared based on Ayurvedic methodology. To study the humoral immune response, rabbit red blood corpuscles (rRBCs) were used as an antigen. Mice were immunized on day 7 and 14 days the start of the experiment using an intraperitoneal injection of 200 µl of rRBCs (2 × 10 8 cells/ml). Humoral immune response, body weight variation, and hematology parameters were studied. CIM-Candy at doses of 10 and 100 mg/kg body weight enhanced the immune function by significantly increasing ( p < 0.05) the hemagglutination antibody titer response against the rRBCs. Significant changes were not observed in body weight and hematology parameters when comparing the normal vehicle control and treatment groups. As the biological activity of the plant-derived formulation was not assigned to a single chemical, high performance thin layer chromatography (HPTLC) fingerprinting was also performed to confirm the chemical characteristic of the formulation. The results of this study suggest that the standardized formulation CIM-Candy

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“…Serial two-fold dilutions of serum samples were made in 50 μL of PBS (pH 7.2) in 96-well microtitre plates and mixed with 50 μL of 1% SRBC suspension in PBS. After mixing, the plates were kept at room temperature for 2 h. The value of the antibody titre was assigned to the highest serum dilution showing visible haemagglutination (Mungantiwar et al, 1999). PFC assay.…”

Section: Animalsmentioning

confidence: 99%

Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata

Khajuria

Gupta

Suden

et al. 2007

Phytotherapy Research

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Oral administration of BOS 2000 (1-10 mg/kg) elicited a dose related increase in the delayed hypersensitivity reaction (early 24 h and delayed 48 h) in mice. It also stimulated the IgM and IgG titre expressed in the form of plaques (PFC) and complement fixing antibody titre. The concentration of cytokines (IL-4, IFN-gamma and TNF-alpha) in serum with respect to T cell interactions, i.e. (CD4/CD8) and the proliferation of lymphocytes were significantly increased at 10 mg/kg compared with the control. The results in these studies demonstrated the immunostimulatory effect of BOS 2000 in a dose-dependent manner with respect to the macrophage activation possibly expressing the phagocytosis and nitrite production by the enhancement of TNF-alpha and IFN-gamma production as a mode of action.

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Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction

Cited by 72 publications

References 4 publications

Punarnava (Boerhaavia Diffusa Linn.): A Comprehensive Review

Punarnava (Boerhaavia Diffusa Linn.): A Comprehensive Review

Immunopotentiating Effect of an Ayurvedic Preparation from Medicinal Plants

Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata

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