Studies on the Infants Born to the Patients with Unexplained Recurrent Abortion Who Underwent Immunotherapy using their Husband’s Lymphocytes

Abstract

Purpose: To investigate the condition of infants born to the patients who underwent Immunotherapy with the Husband's Lymphocytes (LIT) for unexplained recurrent abortion.Method: LIT was performed for the patients with unexplained recurrent abortion, and the pregnancy continued in 129 cases after LIT. The Gestational Weeks at Delivery (GW), the Body Weights (BW) of the infants, as well as major complications, were analyzed in these patients. As a control, the pregnancy outcome was analyzed in 243 cases with no complications and who did not receive LIT.Results: Of 125 cases with singleton pregnancy (4 cases were excluded because of twins), the pregnancy terminated at term in 113 (90.4%), which was not significantly different from that in the control group (209/243, 86.0%, by the Chi-square test). The average GW and BW of infants in the study population and control group were 38W4D ± 2W0D and 38W4D ± 2W3D, 2968 ± 529g and 2904 ± 583g, respectively (not significant by non-paired t-test). There were also no significant differences in the rates of low birth weight and major complications between the two groups. Conclusion:The outcome of pregnancies, especially the condition of infants, of patients after LIT was not significantly different from that of a control population.