Studies on the Lysosomal Degradation of Glycogen in Cultured Human Skin Fibroblasts

Lysosomal glycogen storage induced by Acarbose, a 1,4-α-glucosidase inhibitor

“…It is now well established that in the liver, and some other tissues, a portion of the cellular content of glycogen is associated with the lysosomes (Geddes & Stratton, 1977a;Knecht & Hernandez, 1978;Brown et al, 1978;Rybicka, 1981). Further, this glycogen may be distinguished from that in the cytosol, to various extents, by size, structure and incorporation of radioactive precursors of glycogen synthesis (Geddes & Stratton, 1977a,b;Geddes et al, 1977a,b).…”