Studies on the nutritional basis of abnormal behavior in albino rats: I. The effect of vitamin B1 and vitamin B-complex deficiency on convulsive seizures.

Studies on the nutritional basis of abnormal behavior in albino rats. V. The effect of pyridoxine deficiency upon sound-induced magnesium tetany.

“…A series of studies in this laboratory (52,53,54,55) has produced evidence relating to the nutritional basis for such sound-induced seizures in the rat. A standardized auditory test situation has been used which permits the early detection as well as the repeated induction of the seizure pattern.…”

Vitamin B-complex concentrates and the incidence of sound-induced seizures in young albino rats maintained on purified diets.

“…Patton, Karn, and King (6,7) found that sound-induced seizures appeared when normal young rats were maintained on purified diets deficient in thiamine (vitamin B). The simultaneous appearance of seizures in paired-feeding control animals, however, made it clear that the sensitivity was not directly associated with vitamin Bi deficiency per se but rather with the inanition which accompanied such deprivation.…”

“…Nineteen litters (109 young animals) were fed the basal diet modified by the addition of two per cent rice polish concentrate. 6 Diet IV. Seven litters (41 young animals) received two per cent powdered stomach (Ventriculin 6 ) which was finely pulverized and added to the diet.…”

“…Auditory tests. Standard sound tests were given in a sound-proofed box containing a resonated buzzer (6). All males and females were tested prior to mating.…”

“…4 Procedure for the mixture of dietary components has been previously described (10). 6 Borden and Co., New York, N. Y. 8 Parke-Davis and Co., New York, N. Y.…”