Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents

Janbaz, Khalid Hussain; Saeed, Sheikh A.; Gilani, Anwarul Hassan

doi:10.1016/j.phymed.2003.05.002

Cited by 136 publications

(91 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased activities of serum AST, ALT, ALP, LDH and bilirubin levels are the most sensitive markers employed in the diagnosis of hepatic damage because these are cytoplasmic in location and are released into the circulation after cellular damage [23]. The increased specific activity of the above hepatic enzymes clearly indicates the abnormalities in liver function.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Rajendran

Subash

2010

Ind J Clin Biochem

View full text Add to dashboard Cite

Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar rats. A total of 30 rats weighing 150-170 g were randomly divided into five groups of six rats in each group. Oral administration of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum hepatic markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), bilirubin and increased plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide). The present finding shows that the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were significantly decreased in OXT intoxicated rats. Upon oral administration of caffeic acid (40 mg/kg body weight/day) there were decreased hepatic marker activities, bilirubin and lipid peroxidation and increased enzymatic antioxidants in OXT ? Caffeic acid group compared to Normal ? OXT group(P \ 0.05). Our study suggests that caffeic acid has antioxidant property and hepatoprotective ability against OXT induced toxicity.

show abstract

Section: Resultsmentioning

confidence: 99%

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Rajendran

Subash

2010

Ind J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Qualitative determination of these flavonoids was conducted by HPLC analysis. (Kim et al, 2012) and quercetin (Janbaz et al, 2004), all are famous for its anti-oxidant and hepatoprotective potential. Due to its edible nature, easy accessibility and economical factor, M. nigra can be a good source of active continents having tolerable potential for liver health.…”

Section: Phenolsmentioning

confidence: 99%

Hepatoprotective activity of aqueous methanolic extract of <i>Morus nigra</i> against paracetamol-induced hepatotoxicity in mice

Mallhi

Qadir

Khan

et al. 2014

Bangladesh J Pharmacol

View full text Add to dashboard Cite

Morus nigra (Family Moraceae) is traditionally used injaundice, diabetes, hypertension, cough, fever and cancer. The current study was conducted to determine hepatoprotective activity of aqueous methanolic extract of leaves of M. nigra. Two doses of 250 mg/kg p.o and 500 mg/kg p.o showed that extract of M. nigra produced significant (p<0.001) reduction in liver enzymes (ALT, AST, ALP) and total bilirubin induced by paracetamol and the results are comparable to silymarin (p<0.001). Results were supported by histopathological investigations, phytochemical screening and detection of active constituents by HPLC. The current study showed that aqueous methanolic extract of M. nigra possess hepatoprotective activity that might be due to quercetin, luteolin and isorhamnetin. It was concluded from this study that M. nigra has hepatoprotective activity against paracetamol induced liver injury in mice. Article Info

show abstract

“…Previous investigations showed that rutin and quercetin could ameliorate chemically induced liver damage in rodents [13,14] . The objective of this study was to elucidate the molecular mechanisms of the hepatoprotective activity of rutin against acute toxic liver damage in mice and compare this activity to its aglycone quercetin.…”

Section: Introductionmentioning

confidence: 98%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

View full text Add to dashboard Cite

Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

show abstract

Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents

Cited by 136 publications

References 46 publications

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats

Hepatoprotective activity of aqueous methanolic extract of <i>Morus nigra</i> against paracetamol-induced hepatotoxicity in mice

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Contact Info

Product

Resources

About