Studies on the use of Cassia singueana in malaria ethnopharmacy

Adzu, Bulus; Abbah, J.; Vongtau, H. O.; Gamaniel, K.

doi:10.1016/s0378-8741(03)00257-5

Cited by 54 publications

(33 citation statements)

References 21 publications

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“…Methanolic extract of Cassia singueana showed non-toxic anti-plasmodial activity on P. berghei at 200 mg/kg (Adzu et al, 2003), while 200 mg/kg concentration of both ethanolic and n-hexane extracts of M. oleifera were toxic to the mice, which may be due to high concentration of the extracts.…”

Section: Discussionmentioning

confidence: 95%

In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves

Olasehinde¹,

Ayanda

Egwari³

et al. 2016

IJAB

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This study was carried out to determine the antiplasmodial activity of leaves of Moringa oleifera. Cold extraction method was carried out on grinded leaves to prepare the crude ethanolic and n-hexane extracts. Mice models (Mus musculus) were passaged with chloroquine resistant Plasmodium berghei, which are similar in morphology, physiology and life cycle to P. falciparum that infect humans. Stock solutions of 5 mg/mL 5% DMSO were prepared and the extracts were administered at different treatment concentrations, 50 mg/kg, 100 mg/kg and 200 mg/kg body weight over 4 days. Positive and negative control groups, Chloroquine diphosphate (25 mg/kg) and 5% DMSO, respectively were set up. Crude ethanolic and n-hexane extracts of M. oleifera showed anti-plasmodial activity at the three different concentrations used. Both crude ethanolic and nhexane extracts of M. oleifera leaves showed a significant inhibition of parasitaemia (p < 0.05) ranging from 74.7 to 95.6% for ethanolic extract and 59.3 to 87.9% for n-hexane extract. EC50 value of crude ethanolic and n-hexane extracts were 32 mg/kg and 42 mg/kg body weight, respectively. M. oleifera showed potential for possible future use as an alternative to some conventional drugs.

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Section: Discussionmentioning

confidence: 95%

In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves

Olasehinde¹,

Ayanda

Egwari³

et al. 2016

IJAB

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“…A piperidine alkaloid with antinociceptive property has been reported from C. leptophylla (Alexandre-Moreira et al, 2003). C. singueana is reportedly used during malaria for treatment of pain and fever arising from the disease (Adzu et al, 2003). Antinociceptive and smooth muscle contracting activities has been reported for methanolic extract of Cassia tora leaves (Chidume et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

Seraj

Jahan

Chowdhury

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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The Bedes form one of the largest tribal or indigenous communities in Bangladesh and are popularly known as the boat people or water gypsies because of their preference for living in boats. They travel almost throughout the whole year by boats on the numerous waterways of Bangladesh and earn their livelihood by selling sundry items, performing jugglery acts, catching snakes, and treating village people by the various riversides with their traditional medicinal formulations. Life is hard for the community, and both men and women toil day long. As a result of their strenuous lifestyle, they suffer from various types of pain, and have developed an assortment of formulations for treatment of pain in different parts of the body. Pain is the most common reason for physician consultation in all parts of the world including Bangladesh. Although a number of drugs are available to treat pain, including non-steroidal, steroidal, and narcotic drugs, such drugs usually have side-effects like causing bleeding in the stomach over prolonged use (as in the case of rheumatic pain), or can be addictive. Moreover, pain arising from causes like rheumatism has no proper treatment in allopathic medicine. It was the objective of the present study to document the formulations used by the Bede traditional practitioners for pain treatment, for they claim to have used these formulations over centuries with success. Surveys were conducted among a large Bede community, who reside in boats on the Bangshi River by Porabari village of Savar area in Dhaka district of Bangladesh. Interviews of 30 traditional practitioners were conducted with the help of a semi-structured questionnaire and the guided field-walk method. It was observed that the Bede practitioners used 53 formulations for treatment of various types of pain, the main ingredient of all formulations being medicinal plants. Out of the 53 formulations, 25 were for treatment of rheumatic pain, either exclusively, or along with other types of body pain. A total of 65 plants belonging to 39 families were used in the formulations. The Fabaceae family provided 7 plants followed by the Solanaceae family with 4 plants. 47 out of the 53 formulations were used topically, 5 formulations were orally administered, and 1 formulation had both topical and oral uses. 8 formulations for treatment of rheumatic pain contained Calotropis gigantea, suggesting that the plant has strong potential for further scientific studies leading to discovery of novel efficacious compounds for rheumatic pain treatment.

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“…The use of this plant although known to local dyers as a traditional dye for leather has not been optimized in terms of extraction and dyeing parameters. Available literature however cites the use of the plant in northern Nigeria as an antimicrobial agent and panacea for acute malaria [11,12]. The purpose of this research is to highlight the use of hambo hambo as a source of dye and optimize the extraction and subsequent coloration processes.…”

Section: Introductionmentioning

confidence: 99%

Extraction and Optimization of Natural Dye from Hambo Hambo(Cassia singueana)Plant Used for Coloration of Tanned Leather Materials

Teklemedhin

Ratnapandian

2017

Advances in Materials Science and Engineering

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This investigation was aimed at introducing natural dye extracted from the bark of Cassia Singueana plant for dyeing chrome tanned sheep skin crust leather. The colorant was extracted by aqueous extraction and its strength evaluated using UV-Visible spectroscopy. The extraction with the highest strength (3.9 at max of 400 nm) was obtained at temperature of 95 ∘ C, concentration of 60 g/l, and time of 60 minutes. The possibility of using aloe vera juice and mango bark extract as natural mordants for leather coloration was investigated. Dyeing was conducted with and without mordant using different combinations of temperature, time, pH, and concentration of mordants. All three mordanting techniques were evaluated. The color strength ( / ), CIE * * * values, and fastness properties (light, rubbing, and perspiration) of dyed leather samples were evaluated using appropriate instruments and according to international standards. Majority of samples exhibited that fastness result was in the range of good-excellent. Significantly better color fastness was obtained in case of leather samples premordanted with aloe vera. This study leads to the conclusion that dye extracted from bark of Cassia singueana can be used as colorant for tanned leather with the selected natural mordants.

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Studies on the use of Cassia singueana in malaria ethnopharmacy

Cited by 54 publications

References 21 publications

In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves

In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves

Tribal Formulations for Treatment of Pain: A Study of the Bede Community Traditional Medicinal Practitioners of Porabari Village in Dhaka District, Bangladesh

Extraction and Optimization of Natural Dye from Hambo Hambo(Cassia singueana)Plant Used for Coloration of Tanned Leather Materials

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