Studies on Wound Healing Potential of Polyherbal Formulation using in vitro and in vivo Assays in Swiss Albino Rats

Abstract

Wound healing is a coordinated series of interactions between molecules and cells that results in inflammation, re-epithelization, tissue creation, and remodeling to restore the skin barrier. [1] It is one of the most important subgroups in the broader category of "skin and subcutaneous disorders". A wound is a cellular, anatomic and functional integrity disturbance of the living tissue produced by physical, chemical, electrical or microbiological tissue hazards. They are categorized by the fundamental cause of wound formation. [2] The overall vulnerability of skin and subcutaneous illnesses has grown based upon statistics from the Global Burden of Disease (GBD). Over a ten-year period, the population has increased rapidly, with 605,036, 000 in 2015 compared to 492, 883,000 in 2005. [3] Chronic damage is defined by Werdin et al. 2008 and is not carried out in an ordered and prompt manner after 3 months in order to produce anatomical and functional integrity. [4] The wound healing process completes in three phase: the inflammatory phase (establishment of homeostasis and inflammation), the restorative phase, and the regenerative phase. The

Dermal wound healing contribution of aqueous extracts ofAcalypha indica, Calotropis gigantea, Bacopa monnieriand their combination

“…Use of medicinal plant combinations in the form of polyherbal formulation /combination appears to have a lot of promising potentials in wound treatment and management by decreasing closure time and/or increasing the quality of healed wounds over individual plant treatment. 7,8 The availability of multitargeted groups of phytoconstituents has been considered as the cause for the improved efficacy possessed by these combinatorial preparations. 9,10 Three important medicinal plants (Bacopa monnieri, Acalypha indica, Calotropis gigantea) have been selected to assess their combinatorial wound healing efficacy.…”