Studies related to osteosarcoma and metabolism from 1990 to 2022: A visual analysis and bibliometric study

Abstract

BackgroundOsteosarcoma is the most common primary bone tumor, its high incidence of metastasis and poor prognosis have led to a great deal of concern for osteosarcoma. In many cancer types, metabolic processes are important for tumor growth progression, so interfering with the metabolic processes of osteosarcoma may be a therapeutic option to stall osteosarcoma progression. A key mechanism of how metabolic processes contribute to the growth and survival of various cancers, including osteosarcoma, is their ability to support tumor cell metabolism. Research related to this field is a direction of great importance and potential. However, to our knowledge, no bibliometric studies related to this field have been published, and we will fill this research gap.MethodsPublications were retrieved on January 1, 2023 from the 1990-2022 Science Citation Index of the Web of Science Core Collection. The Bibliometrix package in R software, VOSviewer and CiteSpace software were used to analyze our research directions and to visualize global trends and hotspots in osteosarcoma and metabolism related research.ResultsBased on the search strategy, 833 articles were finally filtered. In this area of research related to osteosarcoma metabolism, we found that China, the United States and Japan are the top 3 countries in terms of number of articles published, and the journals and institutions that have published the most research in this area are Journal of bone and mineral research, Shanghai Jiao Tong University. In addition, Baldini, Nicola, Reddy, Gs and Avnet, Sofia are the top three authors in terms of number of articles published in studies related to this field. The most popular keywords related to the field in the last 30 years are “metabolism” and “expression”, which will guide the possible future directions of the field.ConclusionWe used Bibliometrix, VOSviewer, and Citespace to visualize and bibliometrically analyze the current status and possible future hotspots of research in the field of osteosarcoma metabolism. Possible future hotspots in this field may focus on the related terms “metabolism”, “expression”, and “migraation”.

Non-small cell lung cancer and metabolism research from 2013 to 2023: a visual analysis and bibliometric study

“…Finally, from 2013 to 2023, we analyzed emerging vocabulary in the NSCLC-Met field. CiteSpace is highly advantageous as it can display sudden terminology bursts in a particular research field during a specific time period to potentially reflect hotspots and trends ( 23 ). Keywords appearing in earlier periods indicated that scientists were focusing on the field at earlier stages, while more current keywords indicated the topic had suddenly attracted attention ( 24 ).…”

Unveiling research trends in the prognosis of osteosarcoma: A bibliometric analysis from 2000 to 2022

“…The dual-map overlay visually represents the paths of academic journal distribution, elucidating the exploration of OSA from foundational research to its translation into clinical, nursing, and medical studies. Key contributors to OSA research include Wang Y, Zhang Y, Gorlick R, Ferrari S, and Wang J, who form the backbone of OSA studies [ [26] , [27] , [28] ]. Notably, researchers from China, affiliated with esteemed institutions like Shanghai Jiao Tong University, have made substantial contributions.…”

“…Authors Bacci G and Bielack SS have over 1500 co-citations, underscoring their importance. In the author co-citation network, Mirabello L, Bacci G, and Bielack SS are prominent, establishing strong connections with other top-cited authors, solidifying their influence in OSA research [ [26] , [27] , [28] ].…”

“…Recent research has delved into key areas including biomarkers, tumor microenvironment, immunotherapy, migration, and DNA methylation. Over the past five years, biomarkers, DNA methylation, tumor microenvironment, and immunotherapy have assumed pivotal roles in OSA research, steering exploration into cutting-edge topics [ 26 , 28 , 42 ]. Notably, Osteopontin and PODN biomarkers have been identified, emphasizing their importance in OSA prognosis and management [ 43 , 44 ] .…”

Unraveling T cell exhaustion in the immune microenvironment of osteosarcoma via single-cell RNA transcriptome

“…The microenvironment of OS is primarily hypoxic and acidic. Tumor cells predominantly depend on aerobic glycolysis and fatty acid metabolism to meet their energy demands, a metabolic strategy shared by highly efficient effector T cells [ 28 ]. Consequently, the competition for glucose as well as other fuel sources, such as fatty acids and oxygen, may detrimentally affect the proliferation and activation of effector T cells, culminating in a state of exhaustion within the TIME.…”