Studies to determine antidiarrhoeal and spasmolytic activities of extract of Aegle marmelos. L fruit

Background: Snail mucus (Achatina Fulica) has been known to contain heparan sulfate, and acharan sulfate, a glycosaminoglycan with anti-inflammatory properties and might repair the injured glomeruli. Aim: This study aims to find the effect of snail mucus on activity and chronicity indices of renal histology in a pristane-induced lupus nephritis mice model. Method: This was an experimental study with a post-test-only control group design using 42 mice strains Balb/C. Mice were randomized into six groups: control, lupus nephritis, methylprednisolone, snail mucus 0.5 ccs, snail mucus 0,5 cc and methylprednisolone, and snail mucus one cc and methylprednisolone group. Result: Snail mucus significantly affected the activity index (p = 0.001). The lowest activity index was shown by snail mucus one cc and methylprednisolone group. While the chronicity index was not significantly affected by the snail mucus with p = 0.195. Snail mucus decreases the activity index of renal histology in the pristane-induced lupus nephritis mice model but not the chronicity index. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 515-520

“…However, this research is in line with various other studies to find new drugs for diseases that are difficult to cure [27][28][29] .…”

Section: Discussionsupporting

confidence: 83%

The Effect of Snail Mucus (Achatina Fulica) Toward The Activity and Chronicity Indices of Renal Histology in Pristane-Induced Lupus Nephritis Mice Model

Nurudhin,

Prabowo,

Werdiningsih

et al. 2023

“…Researchers suggested quarantine at the time of the study so that the respondent's activities could be controlled 29,30 .…”

Section: Paired Samples Test Nilai P Keteranganmentioning

confidence: 99%

Irritation Test and Melanin Whitening Cream Epigallocatechin Gallate Green Tea Leaf with Mexameter and Self-Assessment

Widyaningrum,

Fathnin,

Ayu N

et al. 2024

Background: Green tea (Camelia sinensis L.) contains flavonoids consisting of Epigallocatechin gallate (EGCG) which functions as whitening, anti-acne, antioxidant, anti-inflammatory. Previous studies have shown that EGCG with a concentration of 6% is the optimum concentration in cream formulations (Widyaningrum, 2015b). Phase One Clinical Test was conducted to determine the safety of cream preparations with irritation as a benchmark and continued to test its effectiveness as a whitening cream on 20 respondents aged 17-45 years. Material and Methods: The research method employed was the Open Test. The results of the study for 21 days after applying the EGCG anti-acne cream were assessed using a mexa-meter and self-assessment. Result: The erythema assessment showed that the preparation did not cause irritation in the absence of erythema and for the melanin assessment, the results were not significant with p Value 0.376 (<0,05) with no changes in the melanin index. The results of the irritation test were supported by the findings of self-assessment which revealed that all self-assessment parameters were not significant and there was no irritation (p 0,317). Conclusion: Based on the results of the study, it could be concluded that EGCG whitening cream did not cause irritation for 21 days. The results of the melanin test formula for this whitening cream preparation were able to provide a skin whitening effect. Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 102-107

“…There has been an increasing incidence of multiple antibiotic resistances in human pathogenic microorganisms in recent years, largely due to indiscriminate use of commercial antibacterial drugs commonly employed in the treatment of infectious diseases, which have led to the emergence of new bacterial strains that are multi-drug resistant which have resulted in increase in morbidity, mortality and creates enormous health problems. However, the situation is alarming in developing as well as developed countries due to indiscriminate use of antibiotics [3][4][5]54 . The development of drug resistance as well as the appearance of side effects of certain antibiotics has led to the search of new antimicrobial agents mainly among plant extracts with the goal to discover new chemical structures which overcome the above disadvantages [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect of Some Palestinian Plant Extracts against Clinical Multidrug-Resistant Gram- Negative Bacteria: A possible synergism with antibiotics

Elkhair

Elbashiti

Masad

et al. 2020

Objectives: The present study was designed to screen the antibacterial and synergistic effects of Allium sativum, Ecballiumelaterium, Pelargoniumgraveolens, Rosmarinusofficinalis, Phagnalonrupestre and Rutagraveolens plant extracts and essential oils against the followingclinical multidrug-resistant(MDR) Gram negative pathogenic isolates: Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Methods: All extracts and essential oils were screened for their antibacterial activity and synergistic effect in combination with known antibiotics.The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the plant extracts were assessed. Results: Our results revealed that, the average diameter of inhibition zones ranged from: 7-14 mm, 7-17 mm, 8-17 mm and 7-13 mm for water, ethanol, methanol and EOs extracts, respectively. The MICs and MBCs were determined for extracts which showed antibacterial activity. The average MICs values ranged from 1.6-100 mg/ml, 1.6-50 mg/ml, 0.39 -50 mg/ml and 3.13-100 μl/ml for water, ethanol, methanol and EOs extracts, respectively. While MBCs values ranged from 25->200 mg/ml, 25- 200 mg/ml and 50->200 μl/ml for water, ethanol, methanol and EOs extracts, respectively. The antibacterial activity of the afore mentioned plant extracts combined with Ciprofloxacin (CIP), Ampicillin (AM), Cefotaxime (CTX), Nalidixic acid (NA), Norofloxacin (NOR), Cefuroxime (CXM), Cefaclor (CF), Ofloxacin (OFX), Cefalexin (CL), Tetracycline (TE), Rifampicin (RIF), Amoxyclav (AMC) and Amikacin (AK) had different degrees of synergism against the selectedbacteria.Essential oils (Eos) of screened plants had the best synergism with antibiotics than the plant extracts against the tested bacteria. The best synergism was noticed in the Eos of A. sativum, P. graveolens and R. officinalis. Conclusion: It was concluded that the synergistic effect of antibiotics and plant extracts is promising approach fortreating infectious diseases caused byMDR Gram negative bacteria. Bangladesh Journal of Medical Science Vol.19(3) 2020 p.509-519