1979
DOI: 10.1002/cpt1979256837
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Studies with a PNMT inhibitor

Abstract: DCTQ (SK&F 64139) is a potent inhibitor of both adrenal and central nervous system (CNS) phenylethanolamine N-methyltransferase (PNMT). In animal studies, a plasma level of 0.35 microgram/ml was associated with 50% inhibition of both adrenal and central PNMT. We performed single-dose phase I studies with DCTQ in man. Plasma drug levels up to 6.26 microgram/ml were readily obtained. There were few subjective and no objective clinical changes. DCTQ did not alter blood pressure or cause CNS symptoms in man. Furth… Show more

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Cited by 10 publications
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“…The selective EPI antagonist, SK&F 64139, is currently being investigated in man as an antihypertensive agent (48). This drug may also prove useful in the diagnosis and treatment of disorders of GH secretion.…”
Section: Effectsmentioning
confidence: 99%
“…The selective EPI antagonist, SK&F 64139, is currently being investigated in man as an antihypertensive agent (48). This drug may also prove useful in the diagnosis and treatment of disorders of GH secretion.…”
Section: Effectsmentioning
confidence: 99%