Study of acid–base equilibria of fleroxacin

Determination of pKa values of benzimidazole derivatives from mobility obtained by capillary electrophoresis

“…Calculation is straightforward and independent of the solute purity and is a universal technique for determining pK a values over a wide pH range [3]. As reported by different studies, CE is a method of choice compared to multiwavelength spectrophotometric or potentiometric techniques [4,5,18].…”

Fluorescence spectroscopic analysis on interaction of fleroxacin with pepsin

“…K 2 is the orientation factor related to the geometry of the donor and acceptor of dipoles, and K 2 = 2/3 for random orientation as in fluid solution; N is the average refracted index of the medium in the wavelength range where spectral overlap is significant; Ф is the fluorescence quantum yield of the donor; and J is the effect of the spectral overlap between the emission spectrum of the donor and the absorption spectrum of the acceptor, which can be calculated by eqn (7). K 2 is the orientation factor related to the geometry of the donor and acceptor of dipoles, and K 2 = 2/3 for random orientation as in fluid solution; N is the average refracted index of the medium in the wavelength range where spectral overlap is significant; Ф is the fluorescence quantum yield of the donor; and J is the effect of the spectral overlap between the emission spectrum of the donor and the absorption spectrum of the acceptor, which can be calculated by eqn (7).…”

“…E denotes the efficiency of energy transfer between the donor and the acceptor, and R 0 is the critical distance when the efficiency of transfer is 50%. K 2 is the orientation factor related to the geometry of the donor and acceptor of dipoles, and K 2 = 2/3 for random orientation as in fluid solution; N is the average refracted index of the medium in the wavelength range where spectral overlap is significant; Ф is the fluorescence quantum yield of the donor; and J is the effect of the spectral overlap between the emission spectrum of the donor and the absorption spectrum of the acceptor, which can be calculated by eqn (7). F(l) is the corrected fluorescence intensity of the donor in the wavelength range from l to l + Δl; x(l) is the extinction coefficient of the acceptor at l.…”

“…Fleroxacin (FLX, Fig. In clinical trials, FLX has been evaluated in the treatment of urinary tract infections (7,8), gonorrhea and chancroid, nonpneumococcal lower respiratory tract and skin and soft tissue infections and typhoid fever, bacterial enteritis, and traveler's diarrhea (9,10). It has a high antimicrobial activity that encompasses most Gramnegative species (particularly Enterobacteriaceae), a number of Gram-positive organisms and methicillin-sensitive staphylococci (6).…”

“…It has a high antimicrobial activity that encompasses most Gramnegative species (particularly Enterobacteriaceae), a number of Gram-positive organisms and methicillin-sensitive staphylococci (6). In clinical trials, FLX has been evaluated in the treatment of urinary tract infections (7,8), gonorrhea and chancroid, nonpneumococcal lower respiratory tract and skin and soft tissue infections and typhoid fever, bacterial enteritis, and traveler's diarrhea (9,10). It is well absorbed (11) and appears to have less propensity for interactions with other medications in comparison with many other fluoroquinolones (9).…”