Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study

Zende, P D; Bankar, Mangesh P; Momin, Abdul Rahman A; Kamble, Pramod

doi:10.7860/jcdr/2014/7818.4441

Cited by 5 publications

(10 citation statements)

References 33 publications

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“…The rs100775 (CETP) variant was associated with lower levels of HDL-C levels in our study and other studies [17,18,20]. CETP is proatherogenic and promotes the transfer of cholesteryl ester from HDL-C to very low-density lipoprotein (VLDL) rich in triglycerides [22,23,24,47].…”

Section: Resultssupporting

confidence: 76%

“…However, deficiency in LIPC favors the accumulation and circulation of cholesterol-rich atherogenic particles [17]. CETP promotes the transfer of cholesteryl ester from HDL-C to very low-density lipoprotein (VLDL), which is rich in triglycerides [22,23,24]. Its deficiency is thought to be a major reason for high levels of HDL-C in Asians [23].…”

Section: Introductionmentioning

confidence: 99%

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Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex

et al. 2019

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Low high-density lipoprotein cholesterol (HDL-C) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of global mortality. We aimed to determine the effect of coffee drinking and sex and their interaction, as well as rs1800588 and rs1800775 polymorphisms on HDL-C levels in Taiwanese adults. Data of 4262 men and 4813 women, aged 30–70 years, were retrieved from Taiwan Biobank. The interaction between sex and coffee drinking on HDL-C was significant (p = 0.0452). Coffee consumption was significantly associated with higher HDL-C levels in only women (β = 0.81679; p = 0.0246). However, rs1800588 and rs1800775 variants were significantly associated with HDL-C in both sexes. In women, β-values were 0.99080; p = 0.0059 and 3.16277; p < 0.0001 for rs1800588 CT and TT genotypes, respectively and −1.80954; p < 0.0001 and −2.81512; p < 0.0001 for rs1800775 AC and CC genotypes, respectively. In men, β-values were 1.32430; p < 0.0001 and 3.24976; p < 0.0001 for rs1800775 CT and TT genotypes, respectively and −1.96232; p < 0.0001 and −2.71536, p < 0.0001 for the AC and CC genotypes, respectively. In conclusion, coffee drinking was significantly associated with higher high-density lipoprotein (HDL) levels in women but not men after adjusting for confounders including rs1800588 (LIPC) and rs1800775 (CETP) variants.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex

et al. 2019

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“…Among these eligible studies, 33 involved the relationship between CETP rs708272 polymorphisms and CAD ( 15 – 47 ). Other 37 studied five other polymorphisms in the CETP gene, and 14 of them focused on rs5882 ( 15 , 22 , 26 , 29 , 31 , 32 , 35 , 44 , 46 , 50 , 53 , 55 , 59 , 60 ), 11 on rs1800775 ( 26 , 27 , 31 , 32 , 35 , 44 , 52 , 57 – 60 )3 on rs4783961 ( 16 , 35 , 51 ), 3 on rs247616 ( 19 , 48 , 56 ), 2 on rs5883 ( 49 , 54 ), 2 on rs1800776 ( 44 , 60 ), and 2 on rs1532624 ( 19 , 26 ). In addition, 6 studies deviated from HWE ( 19 , 30 , 32 , 39 , 41 , 46 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-six articles involved cases with coronary stenosis ( 15 – 17 , 19 , 20 , 22 – 34 , 36 , 38 – 40 , 43 , 44 , 46 – 54 , 56 , 57 , 59 ), and 10 involved cases with myocardial infarction ( 18 , 21 , 35 , 37 , 41 , 42 , 45 , 55 , 58 , 60 ).…”

Section: Resultsmentioning

confidence: 99%

Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

Zhang,

Xie,

Xiao

2023

Front. Cardiovasc. Med.

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AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.

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“…A few other studies have shown an association between CETP and lipid metabolism 16 33 34 . The reports from India are varied as each has looked at different CETP polymorphisms and HDL-C metabolism 35 36 . In the study by Dixit et al 36 , lipid profile analysis did not show any significant difference in distribution among genotypes of CETP polymorphism among patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting high-density lipoprotein cholesterol in HIV-infected patients on nevirapine-based antiretroviral therapy

Padmapriyadarsini

Ramesh

Sekar

et al. 2017

Indian Journal of Medical Research

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Background & objectives: Cardiovascular disease (CVD) risk with low high-density lipoprotein cholesterol (HDL-C) and high triglycerides is common in the general population in India. As nevirapine (NVP)-based antiretroviral therapy (ART) tends to increase HDL-C, gene polymorphisms associated with HDL-C metabolism in HIV-infected adults on stable NVP-based ART were studied. Methods: A cross-sectional study was conducted between January 2013 and July 2014 among adults receiving NVP-based ART for 12-15 months. Blood lipids were estimated and gene polymorphisms in apolipoprotein C3 (APOC3), cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) genes were analyzed by real-time polymerase chain reaction. Framingham's 10-yr CVD risk score was estimated. Logistic regression was done to show factors related to low HDL-C levels. Results: Of the 300 patients included (mean age: 38.6±8.7 yr; mean CD4 count 449±210 cell/μl), total cholesterol (TC) >200 mg/dl was observed in 116 (39%) patients. Thirty nine per cent males and 47 per cent females had HDL-C levels below normal while 32 per cent males and 37 per cent females had TC/HDL ratio of 4.5 and 4.0, respectively. Body mass index [adjusted odds ratio (aOR)=1.70, 95% confidence interval (CI) 1.01-2.84, P=0.04] and viral load (aOR=3.39, 95% CI: 1.52-7.52, P=0.003) were negatively associated with serum HDL-C levels. The 10-yr risk score of developing CVD was 11-20 per cent in 3 per cent patients. Allelic variants of APOC3 showed a trend towards low HDL-C. Interpretation & conclusions: High-risk lipid profiles for atherosclerosis and cardiovascular disease were common among HIV-infected individuals, even after 12 months of NVP-based ART. Targeted interventions to address these factors should be recommended in the national ART programmes.

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Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study

Cited by 5 publications

References 33 publications

Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex

Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex

Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis

Factors affecting high-density lipoprotein cholesterol in HIV-infected patients on nevirapine-based antiretroviral therapy

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