Study of Coagulation Profile in Patients of Pregnancy Induced Hypertension-A Single Centric Prospective Study

Evaluation of Coagulation Indices in Preeclampsia and Eclampsia

“…Platelet activation may lead to increased generation of thromboxane A2 and serotonin release, in turn increase vasoconstriction and platelet aggregation. The present study correlates well with the study by Chaudhary S et al, 9 Chavan et al 18 and Jambhulkar et al 19 In the present study, mean platelet count show statistically significant difference (p-0.000) between study and control groups which correlates well with other authors such as Chaudhary S et al 9 Table 3 shows that even though there is not much decrease in platelet count between control group and mild preeclampsia group, there is significant (p-0.000) decrease in platelet count with increase in severity of disease. Several studies have also shown similar findings such as Chaudhary S et al, 9 Chaware S A et al, 15 Awolola OO et al, 25 and Sharma UK et al 26 Comparing the degree of thrombocytopenia in various severity of pregnancy induced hypertension in the present study, as the severity of PIH increases; not only the number of cases with thrombocytopenia increase but also the platelet counts are decreasing which correlates well with other authors such as Priyanka P et al 27 and Chaware S A et al 15 The much higher occurrence of thrombocytopenia among sever preeclampsia and eclampsia patients in the present study can be explained by the poor socioeconomic status of the patients, leading to lack of antenatal check-ups and late presentation of women with PIH to the hospital only after developing severe systemic symptoms.…”

“…In the present study, no cases had prolonged PT in control as well as mild preeclampsia groups but severe preeclampsia and eclampsia group had prolonged PT which correlates with other studies such as Chaudhary S et al 9 and Lakshmi CV et al 8 The mean prothrombin time in control and mild preeclampsia were very similar but was significantly increased (p< 0.05) in severe preeclampsia and eclampsia groups in the present study which can be correlated with the study conducted by Priyadarshini G et al 6 and Chaware S A et al 15 The presence of higher number of cases with prolonged PT can be explained by the higher proportion of patients with thrombocytopenia, since it's now widely accepted that endothelial damage leading to platelet activation and aggregation is the driving force behind the pathophysiology of preeclampsia.…”

“…In the present study, no prolongation of aPTT among mild preeclampsia but severe preeclampsia and eclampsia group had prolonged aPTT which correlated well with the study by Chaudhary S et al, 10 Chaware S A et al 15 and Lakshmi CV et al 8 The mean aPTT in control and mild preeclampsia were very similar but was also significantly increased (p<0.05) in severe preeclampsia and eclampsia groups in the present study. Similar findings were documented by Jambhulkar et al, 19 Priyadarshini G et al, 6 Chaware S A et al 15 and Chaudhary S et al 9 Table 5.…”

“…Biochemical coagulopathy was unlikely at platelet count above 1 lac/µl. The finding that only participants with low platelet count were found to have biochemical coagulopathy has previously been documented by authors such as Priyadarshini G et al, 6 Nirmala T et al 7 and Chaudhary S et al 9 and Leduce L et al 10 It has been postulated that lower platelet count is associated with abnormal activation of coagulation system and is believed to reflect increased platelet consumption.…”