Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems

Tapia, C.; Ormazabal, Víctor; Costa, Edda; Yazdani‐Pedram, Mehrdad

doi:10.1080/03639040601085359

Cited by 16 publications

(9 citation statements)

References 17 publications

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“…While pure CS is soluble in low pH and insoluble in higher pH, alginate shows the opposite trend. However, a stable rigid drug delivery matrix of the alginate-CS polyelectrolyte complex can be produced by the electrostatic interaction between the carboxyl groups of alginic acid and amino groups on CS, which can protect the drug from the harsh acidic environment of the stomach (51,(82)(83)(84)(85)(86). Recently, this alginate-CS polyelectrolyte complex have also been utilised for the preparation of oral NPs (14,56,87).…”

Section: Alginate-modified Chitosanmentioning

confidence: 99%

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

2010

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Abstract. Nanoparticles composed of naturally occurring biodegradable polymers have emerged as potential carriers of various therapeutic agents for controlled drug delivery through the oral route. Chitosan, a cationic polysaccharide, is one of such biodegradable polymers, which has been extensively exploited for the preparation of nanoparticles for oral controlled delivery of several therapeutic agents. In recent years, the area of focus has shifted from chitosan to chitosan derivatized polymers for the preparation of oral nanoparticles due to its vastly improved properties, such as better drug retention capability, improved permeation, enhanced mucoadhesion and sustained release of therapeutic agents. Chitosan derivatized polymers are primarily the quaternized chitosan derivatives, chitosan cyclodextrin complexes, thiolated chitosan, pegylated chitosan and chitosan combined with other peptides. The current review focuses on the recent advancements in the field of oral controlled release via chitosan nanoparticles and discusses about its in vitro and in vivo implications.

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Section: Alginate-modified Chitosanmentioning

confidence: 99%

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

2010

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“…Tablets are the most common oral solid dosage forms, because they are convenient to carry, the duration of action of the contained drugs can be controlled 1,2) and their taste or smell can be improved. 3,4) Although powder or capsule dosage forms are also useful orally, they have the drawback of attaching to the throat or pharynx, indicating that tablets have superior usability; however, elderly people and children often have difficulty swallowing conventional tablets or capsules.…”

mentioning

confidence: 99%

Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent

Koseki

Onishi

Uchida

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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It was attempted to produce novel furosemide (FS) fast-disintegrating tablets by direct compression. The combination of FS, microcrystalline cellulose, croscarmellose sodium and xylitol was used as the basic formulation, and sucrose stearic acid ester (SSE) was chosen as an additional additive. The tablets with SSE were prepared by the simple addition of SSE, using a lyophilized mixture of FS and SSE or using a FS/SSE mixture obtained by evaporation of their ethanol solution. Only the tablets, produced using the FS/SSE mixture obtained by organic solvent (ethanol) evaporation, showed hardness of more than 30 N and a disintegration time of less than 20 s, which were the properties suitable for fast-disintegrating tablets. These properties were considered to result from well-mixed and fine-powdered SSE and FS.

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“…Gelatin Microparticles, beads, tablets [97][98][99] Mixture of alginate and gelatin is crosslinked by calcium chloride or coacervated through pH modification of the blend. Glutaraldehyde and sodium carboxymethylcellulose may be added as additional crosslinking agent and as particle aggregation inhibitor respectively.…”

Section: +mentioning

confidence: 99%

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Wong

2011

Journal of Pharmacy and Pharmacology

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Objectives Use of alginate graft copolymers in oral drug delivery reduces dosage form manufacture complexity with reference to mixing or coating processes. It is deemed to give constant or approximately steady weight ratio of alginate to covalently attached co-excipient in copolymers, thereby leading to controllable matrix processing and drug release. This review describes various grafting approaches and their outcome on oral drug release behaviour of alginate graft copolymeric matrices. It examines drug release modulation mechanism of alginate graft copolymers against that of co-excipients in non-grafted formulations. Key findings Drug release from alginate matrices can be modulated through using either co-excipients or graft copolymers via changing their swelling, erosion, hydrophobicity/ hydrophilicity, porosity and/or drug adsorption capacity. However, it is not known if the drug delivery performance of formulations prepared using alginate graft copolymers is superior to those incorporating graft-equivalent co-excipient physically in a dosage form without grafting but at the corresponding graft weight, owing to limited studies being available. Conclusions The value of alginate graft copolymers as the potential alternative to alginate-co-excipient physical mixture in oral drug delivery cannot be entirely defined by past and present research. Such an issue is complicated by the lack of green chemistry graft copolymer synthesis approach, high grafting process cost, complications and hazards, and the formed graft copolymers having unknown toxicity. Future research will need to address these matters to achieve a widespread commercialization and industrial application of alginate graft copolymers in oral drug delivery

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Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems

Cited by 16 publications

References 17 publications

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

Recent Advancement of Chitosan-Based Nanoparticles for Oral Controlled Delivery of Insulin and Other Therapeutic Agents

Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

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