Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence

Asare-Addo, Kofi; Levina, Marina; Rajabi‐Siahboomi, Ali R.; Nokhodchi, Ali

doi:10.1016/j.colsurfb.2010.07.040

Cited by 35 publications

(38 citation statements)

References 46 publications

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“…It is particularly critical in the case of dosage forms that are subject to erosion, such as hydrophilic matrices (Kavanagh, Corrigan, 2004;Missaghi, Fassihi, 2005;Asare-Addo et al, 2010). Although it may be difficult to select the agitation intensity that best mimics in vivo conditions, it is common to use 5-15 dips per minute (dpm) to simulate the fasted state and 30-40 dpm for the fed state, thus representing the greater turbulence within the stomach (Borst, Ugwu, Beckett, 1997).…”

Section: Simulation Of Fasted and Fed Statesmentioning

confidence: 99%

“…Considering that erosion is the dominant release mechanism from HPMC tablets containing poorlysoluble drugs and that the presence of food components in gastrointestinal tract have a critical effect on tablet disintegration, different dip rates from this apparatus in the evaluation of these dosage forms could be related to food effects on HPMC erosion (Asare-Addo et al, 2010).…”

Section: Advantages Over Traditional Me-thodsmentioning

confidence: 99%

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Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Pezzini

Issa

Duque

et al. 2015

Braz. J. Pharm. Sci.

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USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a single run. In this paper, a brief history and a description of this system are presented, along with its applications in the development of immediate and modified release products and in the simulation of fasted and fed states using biorelevant media. Furthermore, a comparison is made with the basket and paddle apparatus, especially highlighting the superior hydrodynamics of USP apparatus 3, since the results are not sensitive to factors such as the presence of sample collection probes or air bubbles in the dissolution medium.Uniterms: Solid dosage forms/in vitro release. Solid dosage forms/dissolution. Apparatus 3/use/evaluation of solid dosage forms. Reciprocating cylinders.USP aparato 3 (cilindros recíprocos) é um equipamento bastante versátil para a avaliação das características de liberação in vitro de formas farmacêuticas sólidas orais, pois permite que o produto seja submetido a diferentes meios de dissolução e condições de agitação, em um único ensaio. Neste trabalho, são apresentados um breve histórico e a descrição desse sistema, suas aplicações no desenvolvimento de produtos de liberação imediata e modificada, assim como sua utilização na simulação dos estados não alimentado e alimentado com o emprego de meios biorrelevantes. Além disso, uma comparação é estabelecida com o cesto e a pá, com destaque para a hidrodinâmica superior do USP aparato 3, que faz com que os resultados não sejam influenciados por fatores como o uso de sondas de coleta de amostras ou presença de bolhas de ar no meio de dissolução.Unitermos: Formas farmacêuticas sólidas/liberação in vitro. Formas farmacêuticas sólidas/dissolução. USP Aparato 3/uso/avaliação de formas farmacêuticas sólidas. Cilindros recíprocos.

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Section: Simulation Of Fasted and Fed Statesmentioning

confidence: 99%

Section: Advantages Over Traditional Me-thodsmentioning

confidence: 99%

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Pezzini

Issa

Duque

et al. 2015

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

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“…These two proper-ties vary greatly along the GI tract under fasted and fed conditions [91,95,166]. These factors may affect the rate at which a drug is released from its hydrophilic gel matrix [6][7][8][9][10]165,167,168].…”

Section: Numerous Other In-vitromentioning

confidence: 99%

“…Asare-Addo et al [6] introduced a simple method to differentiate between robust and nonrobust or poor formulations. They evaluated the influence of agitation in *ascending and **descending sequences as a systematic method of development process to potentially discriminate between fed and fasted states (*ascending order of agitation: agitation was increased by 5 dips/min [dpm] every time the cylinder containing the dosage form moved from one vial to the other.…”

Section: Numerous Other In-vitromentioning

confidence: 99%

“…This review looks to summarise the physiological parameters that can affect drug release, discuss food effect on drug release and some of the dissolution methods used in trying to predict in vivo dissolution behaviour. This review will also look at a simple in vitro methodology developed by Asare-Addo et al by varying agitation in ascending and descending sequences as a systematic process for potentially discriminating fasted and fed states to represent the various levels of agitation to mimic the fed and fasted states in man [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Drug release from matrix tablets: physiological parameters and the effect of food

Nokhodchi

Asare-Addo

2014

Expert Opinion on Drug Delivery

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Introduction: As dissolution plays an important and vital role in the drug-delivery process of oral solid dosage forms, it is, therefore, essential to critically evaluate the parameters that can affect this process. Areas covered:The consumption of food as well as the physiological environment and properties of the gastrointestinal tract, such as its volume and composition of fluid, the fluid hydrodynamics, properties of the intestinal membrane, drug dose and solubility, pK a , diffusion coefficient, permeability and particle size, all affect drug dissolution and absorption rate. There are several dissolution approaches that have been developed to address the conditions as experienced in the in vivo environment, as the traditional dissolution being a quality control method is not biorelevant and as such do not always produce meaningful data. This review also describes the development of a systematic way that differentiates between robust and non-robust formulations by varying the effects of agitation and ionic strength through the use of the automated United States Pharmacopeia type III Bio-Dis apparatus. Expert opinion:With the improved understanding of the physiological parameters that can affect the oral bioperformance of dosage forms, strides have, therefore, been made in making dissolution testing methods more bio-logically based with the view of obtaining more in vitro--in vivo correlations.Keywords: agitation rate, biodissolution, drug release, effect of food, hydrophilic matrices, ionic strength Highlights -Understanding all the physiological parameters can serve as a basis for designing dissolution testing methods and systems that can more fully represent the gastrointestinal (GI) tract in humans and allow more in vitro-in vivo (IVIVC) correlations to be obtained thereby improving the oral bioperformance of dosage forms.-Simulation of GI conditions is essential to adequately predict the in vivo behaviour of drug formulations.-The choice of appropriate media for in vitro tests is crucial to their ability to correctly forecast the food effect in pharmacokinetic studies.-Several methods of dissolution testing have been conducted and are still ongoing that seek to further understand and develop media and dissolution methods to better represent the in vivo conditions and to aid in the better prediction of in vivo drug release.-Systematic change of agitation method and ionic strength evaluation may be used as additional tools in allowing for the identification of potential fed and fasted effects on drug release from hydrophilic matrices in the drive for developing dissolution methodologies that are more relevant in helping to achieve more IVIVC.

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Application of Polymer Combinations in Extended Release Hydrophilic Matrices

Nokhodchi

Palmer²,

Asare-Addo

et al. 2015

Handbook of Polymers for Pharmaceutical Technologies

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DESCRIPTIONPolymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe.This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated.

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Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence

Cited by 35 publications

References 46 publications

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Drug release from matrix tablets: physiological parameters and the effect of food

Application of Polymer Combinations in Extended Release Hydrophilic Matrices

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