Study of dissolution profiles and desintegration of capsules containing the dried hydroethanolic extract of Calophyllum brasiliense

Carvalho, Helison de Oliveira; Medeiros, Benedito Junior; Sá, Beatriz M. de; Araújo, Jennifer Thayanne Cavalcante de; Kawakami, Monique; Favacho, Hugo Alexandre Silva; Carvalho, José Carlos Tavares

doi:10.1590/s0102-695x2012005000145

Cited by 9 publications

(12 citation statements)

References 13 publications

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“…Trata-se de planta com alto potencial madeireiro e com boa possibilidade de cultivo, especialmente em áreas úmidas, com moderado excesso de água, próximas a cursos de água (Oliveira & Joly, 2010;Schultz, 2011). A espécie também tem importância farmacêutica, por possibilitar a extração de metabólitos derivados de xantonas, cumarinas, flavonoides e terpenos, que têm ação antibacteriana, moluscicida, anti-hipertensiva e atividade contra imunodeficiência humana (HIV-1) (Noldin et al, 2006;Braga et al, 2007;Bernabé-Antonio et al, 2010;Carvalho et al, 2013).…”

Section: Introductionunclassified

Técnicas para superação da dormência de sementes de guanandi

Silva

Vieira

Panobianco

2014

Pesq. agropec. bras.

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Resumo -O objetivo deste trabalho foi avaliar tipos de preparo de sementes de guanandi (Calophyllum brasiliense), com vistas à superação da dormência física e mecânica, e verificar a influência da temperatura e do substrato sobre a germinação. Foram avaliados três substratos (papel, areia e vermiculita), duas temperaturas de germinação (25 e 30ºC) e quatro tipos de preparo das sementes: sementes íntegras; sementes nuas, sem tegumento e endocarpo; sementes com punctura no endocarpo, na região próxima ao eixo embrionário ou na região oposta ao eixo embrionário; e sementes cortadas a 1/3 da região oposta ao eixo embrionário. Foram realizados testes de vigor (índice de velocidade de germinação e emergência de plântulas em campo), e a curva de embebição foi obtida para os diferentes tipos de preparo da semente. A retirada total do envoltório (endocarpo e tegumento) é necessária para a completa superação da dormência física e mecânica das sementes de guanandi. A germinação das sementes deve ser realizada em substrato papel à temperatura de 30ºC.Termos para indexação: Calophyllum brasiliense, espécie nativa, germinação, madeira de lei, sementes recalcitrantes, testes laboratoriais. Techniques for overcoming dormancy in guanandi seedsAbstract -The objective of this work was to evaluate different types of preparation of guanandi (Calophyllum brasiliense) seeds, in order to overcome physical and mechanical dormancy, and to verify the effects of temperature and substrate on germination. Three substrates (paper, sand, and vermiculite), two germination temperatures (25 and 30ºC), and four seed preparation types were evaluated: whole seeds; bare seeds, without testa and endocarp; seeds with punctured endocarp in the region near the embryonic axis or in the region opposite of the embryonic axis; and seeds cut at 1/3 of the region opposite of the embryonic axis. Vigor tests were performed (index of germination speed and emergence of seedlings in the field), and the imbibition curve was obtained for the different types of seed preparation. Total wrap (endocarp and testa) withdrawal is necessary to completely overcome physical and mechanical dormancy of guanandi seeds. Seed germination should be held in paper substrate at a temperature of 30°C.

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Section: Introductionunclassified

Técnicas para superação da dormência de sementes de guanandi

Silva

Vieira

Panobianco

2014

Pesq. agropec. bras.

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“…In a study conducted by Carvalho et al (2013), the Cb extract showed high levels of polyphenolic compounds, and these natural antioxidants have great potential for the treatment of DM, as several studies have proven the hypoglycemic activity attributed to these compounds (Hou et al, 2007;Jia et al, 2009;Panda and Kar, 2007).…”

Section: Resultsmentioning

confidence: 99%

“…5 mL of this solution were transferred to a 50 mL volumetric flask, and then 2 mL of acid phosphomolybdotungstic reagent (Sigma Co., São Paulo, Brazil) were added and the volume was completed with sodium carbonate solution of 15% (Sigma Co., São Paulo, Brazil). Later, the absorbance was measured in a 760 nm UV-VIS spectrophotometer (Shimadzu, UVmini-1240 model), according to the methodology described by Carvalho et al (2013) For the HPLC chromatographic analysis, 10 mg of CBE were weighed and added to 10 mL of methanol:water solution (2:8 v/v); then, filtered through membrane filter with a pore size of 0.45 micrometers (Millepore ® ) and analyzed by high-performance-HPLC (Shimadzu Corporation) equipped with auto injector, diode array detector scanned from 190 to 500 nm. Chromatographic conditions were: Chromatograms obtained at 350 nm, oven with temperature kept at 30°C, reverse phase column (C18), Shim-pack VP-ODS (150 × 4.6 mm; 5 µm), injection volume of 10 µL using methanol as phase A: water acidified with 0.05% of acetic acid (70:30) and acetonitrile as phase B, in proportions isocratic system of 70% phase A with flow rate of 1 mL/min.…”

Section: Quantitativementioning

confidence: 99%

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Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

Carvalho¹,

Lacerda²,

Ferreira³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Calophyllum brasiliense (Cb) belongs to the Clusiaceae family and it is generally used for diabetes treatment. The aim of this study was to evaluate the anti-diabetic effect of Cb's hydroethanolic extract (CBE) on diabetic induced rats by streptozotocin and evaluate the content of polyphenols and tannins of the extract. The polyphenols and tannins evaluation in the extract were determinated by a spectrophotometer in 760 nm and isocratic HPLC system and reverse phase column (C18). The induction of diabetes was performed by intraperitoneal injection of streptozotocin (55 mg/kg) and was confirmed by a histopathological analysis. The total content of polyphenols and tannins (gallic acid) in CBE was 0.025 ± 0.0028 mg/mL (4.77%) and 8.262 ± 0.417 µg/mL, respectively. According to the oral glucose tolerance test that was performed both in normal and diabetic mice, the treatment with 500 mg/kg of CBE appeared to significantly reduce the blood glucose levels compared to the untreated group (P < 0.001). The treatment of diabetic mice with 500 mg/kg of CBE for 30 days significantly improved diabetes clinical symptoms (polydipsia, polyuria, polyphagia and weight loss) (P < 0.001). After the urinary glucose analysis, it was found that the treatment with 500 mg/kg of CBE significantly decreased the urinary glucose levels at an average of 177.55 ± 17.8 mg/dL (32.40%) (P < 0.001). In relation to the blood glucosemeasurements, it was shown that the groups treated with 500 mg/kg CBE and 3 mg/kg of Glibenclamide had significantly lower levels of blood glucose when compared to nontreated group (P < 0.001) 24.09% (143.36 ± 19.6 mg/dL) and 36.04% (200.08 ± 14.9 mg/dL), respectively). The histopathological analysis revealed an increase in the number of endocrine cells in the islets of Langerhans in the groups treated with CBE500 and insulin. Therefore, it was concluded that the treatment with 500 mg/kg of CBE exhibited anti-diabetic activity.

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“…It features a wide variety of secondary metabolites isolated from leaves, bark, roots, flowers and fruits, such as xanthones, terpenes, chromanones and flavonoids, which exhibit multiple medicinal properties (Noldin et al, 2006;Bernabé-Antônio et al, 2010;Carvalho et al, 2013). It is also suitable for reforestation, especially to restore the vegetation in locations subjected to periodic short-term floods, as well as areas with a permanently soggy soil (Carvalho, 1994;Souza, 2009).…”

Section: Introductionmentioning

confidence: 99%

Storage of Calophyllum brasiliense Cambess. seeds

et al. 2016

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Calophyllum brasiliense is a species native to Brazil and has potential for use in the timber industry, in the reforestation of degraded areas, besides having medicinal properties. Its propagation is mainly by seeds which, depending on their recalcitrant characteristics, leads to difficulty in conservation, due to changes in its physiological potential during storage. Aiming to contribute to the expansion of its cultivation, rational use and conservation, the objective of this study was to investigate the behavior of C. brasiliense seeds during storage. Different packings (paper, aluminum and polyethylene) and environmental conditions (room temperature and cold chamber) were quarterly tested over 12 months, by evaluating germination viability and vigor. Based on the results, it was concluded that packaging in polyethylene and freezer storage provided the best conditions for the conservation of seeds, keeping them viable for a period of nine months.Keywords: Guanandi, forest species, conservation, longevity, recalcitrance. Armazenamento de sementes de Calophyllum brasiliense Cambess. ResumoCalophyllum brasiliense é uma espécie nativa do Brasil e está na lista de espécies recomendadas para o reflorestamento de áreas degradadas, além de possuir propriedades medicinais e madeireiras. Sua propagação se dá principalmente via sementes, as quais, em função das suas características recalcitrantes, apresentam dificuldade de conservação, devido a alterações no seu potencial fisiológico ao longo do armazenamento. Visando contribuir com a ampliação de seu cultivo, uso racional e conservação, objetivou-se investigar o comportamento das sementes de C. brasiliense durante 12 meses de armazenamento. Testou-se diferentes embalagens (papel, alumínio e polietileno) e condições ambientais (câmara fria e temperatura ambiente), avaliando-se trimestralmente a germinação, viabilidade e vigor. Com base nos resultados obtidos conclui-se que o acondicionamento em embalagem de polietileno e o armazenamento em câmara fria proporcionou a melhor condição para a conservação das sementes, mantendo essas viáveis por um período de nove meses.Palavras-chave: Guanandi, espécie florestal, conservação, longevidade, recalcitrância.

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Study of dissolution profiles and desintegration of capsules containing the dried hydroethanolic extract of Calophyllum brasiliense

Cited by 9 publications

References 13 publications

Técnicas para superação da dormência de sementes de guanandi

Técnicas para superação da dormência de sementes de guanandi

Effect of hydroethanolic extract from Calophyllum brasiliense Cambess on streptozotocin induced diabetic rats

Storage of Calophyllum brasiliense Cambess. seeds

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