Study of distribution and interaction of arsenic and selenium in rat thyroid

Glattre, Eystein; Mravcová, A.; Lener, Jaroslav; Vobecký, Miloslav; Egertova, E; Mysliveckova, M

doi:10.1007/bf02788967

Cited by 44 publications

(20 citation statements)

References 16 publications

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“…Selenium in turn facilitated the biliary excretion of arsenic. Glattre et al studied the distribution and interaction of arsenic and selenium in rat thyroid and suggested that both arsenic and selenium accumulate in thyroid tissue 119) . Toxic changes were seen during post mortem examination, whereas only minor changes were observed in the selenium or arsenic plus selenium treated groups.…”

Section: Seleniummentioning

confidence: 99%

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Kalia¹,

Flora²

2005

Journal of Occupational Health

269

161

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Strategies for Safe and Effective Therapeutic Measures for Arsenic and LeadPoisoning: Kiran Kalia, et al. Department of Biosciences, Sardar Patel University, IndiaExposure to toxic metals remains a widespread occupational and environmental problem in world. There have been a number of reports in the recent past suggesting an incidence of childhood lead poisoning and chronic arsenic poisoning due to contaminated drinking water in many areas of West Bengal in India and Bangladesh has become a national calamity. Low level metal exposure in humans is caused by air, food and water intake. Lead and arsenic generally interferes with a number of body functions such as the central nervous system (CNS), the haematopoietic system, liver and kidneys. Over the past few decades there has been growing awareness and concern that the toxic biochemical and functional effects are occurring at a lower level of metal exposure than those that produce overt clinical and pathological signs and symptoms. Despite many years of research, we are still far from an effective treatment of chronic plumbism and arsenicosis. Medical treatment of acute and chronic lead and arsenic toxicity is furnished by chelating agents. Chelating agents are organic compounds capable of linking together metal ions to form complex ring-like structures called chelates. They have been used clinically as antidotes for acute and chronic poisoning. 2, 3-dimercaprol (BAL) has long been the mainstay of chelation therapy for lead or arsenic poisoning. Meso 2, 3, -dimercaptosuccinic acid (DMSA) has been tried successfully in animals as well as in a few cases of human lead and arsenic poisoning. DMSA could be a safe and effective method for treating lead or arsenic poisoning, but one of the major disadvantages of chelation with DMSA has been its Review inability to remove lead from the intracellular sites because of its lipophobic nature. Further, it does not provide protection in terms of clinical/ biochemical recovery. A new trend in chelation therapy is to use combined treatment. This includes the use of structurally different chelators or a combination of an adjuvant and a chelator to provide better clinical/ biochemical recovery in addition to lead mobilization. The present review article attempts to provide update information about the current strategies being adopted for a safe, effective and specific treatment for two major toxic metals or metalloid.

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Section: Seleniummentioning

confidence: 99%

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Kalia¹,

Flora²

2005

Journal of Occupational Health

269

161

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“…Inorganic arsenic has been shown to modify metabolism of selenium and influence the anti-carcinogenic activity of inorganic and organic selenium compounds 23,24 . Some data also demonstrate that pre-or co-exposure to inorganic selenium exerts protective effect against toxicity of arsenic [25][26][27] . In our study the level of arsenic cumulation in the thyroid was not significantly influenced by dietary selenium supplementation.…”

Section: Discussionmentioning

confidence: 94%

Effect of long-term administration of arsenic (III) and bromine with and without selenium and iodine supplementation on the element level in the thyroid of rat

Kotyzová¹,

Eybl²,

Mihaljevič³

et al. 2005

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The aim of this study was to evaluate the influence of arsenic and bromine exposure with or withour iodine and selenium supplementation on the element level in the thyroid of rats. Four major groups of Wistar female rats were fed with respective diets: group A -standard diet, group B -iodine rich diet (10 mg I/kg food), group C -selenium rich diet (1 mg Se/kg) and group D -iodine and selenium rich diet (as in group B and C). Each group was divided into four subgroups per 7 animals each receiving either NaAsO 2 ip (6.5 mg.kg -1 twice a week for two weeks and 3.25 mg.kg -1 for six weeks) or KBr in drinking water (58.8 mg.l -1 ) for 8 weeks or combined administration of both substances. Remaining subgroup served as controls. After 8 weeks thyroid glands were analyzed by ICP-MS for As, Br, Se, and I content. The exposition of rat to arsenic or bromine causes the accumulation of these elements in the thyroid gland (∼18 ppm of As, ∼90 ppm of Br) and significantly affects iodine and selenium concentration in the thyroid. In iodine and/or selenium supplemented rats the bromine intake into the thyroid was lowered to ∼50% of the level in unsupplemented animals. Also selenium thyroid level elevated due to KBr administration was lowered by iodine supplementation in the diet. The accumulation of arsenic in the thyroid was not influenced by selenium or iodine supplementation; however, As(III) administration increased iodine thyroid level and suppressed selenium thyroid level in selenium or iodine supplemented group of animals.

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“…In 1995 we published a study (14) of the distribution and interaction of arsenic and selenium in the rat thyroid. This was meant as supplement to previous selenium studies, and was based on one of the subhypotheses that can be deduced from the seafood hypothesis: Seafood has been the main human source of arsenic in the second half of the twentieth century.…”

Section: The Experimental Armmentioning

confidence: 99%

“…• The thyroid gland as target tissue for selenium, arsenic and tellurium (neighbors in the periodic system) (14,27). …”

Section: Selected Achievementsmentioning

confidence: 99%

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

Glattre¹

2011

Nor J Epidemiol

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The Norwegian Thyroid Cancer Project was established in 1985. Its crew has consisted of an interdisciplinary group of scientists, and its secretariat has been part of the Cancer Registry of Norway since day 1. The aim has been to describe the occurrence of thyroid cancer in Norway, investigate etiological aspects and publish results. Focus has been on the papillary carcinoma of the thyroid, the most incident type of thyroid neoplasia in Norway. Important results of the Project are briefly mentioned. Some forty publications have been produced, mostly epidemiological analyses, but also some experimental studies. The results of the Project and of others have led to the acknowledgement that thyroid carcinogenesis is a complexity-phenomenon partly inaccessible to common scientific procedure. NORSK SAMMENDRAGCancer thyreoidea prosjektet kom igang i 1985. De forskere som har arbeidet innenfor prosjektet, har hatt forskjellig faglig bakgrunn. Prosjektsekretariatet har ligget i Kreftregisteret helt fra starten av. Målsetningen har hele tiden vaert å beskrive opptredenen av skjoldkjertelkreft i Norge samt gjøre etiologiske undersøkelser. Fokus har vaert på det papillaere carcinom som er det hyppigste her til lands. En del viktige forskningsresultater blir kort omtalt. Det er produsert ca. 40 publikasjoner i regi av Prosjektet, den overveiende del er epidemiologiske analyser, i tillegg noen dyreeksperimenter. De samlede erfaringene har ført til den erkjennelse at thyreoidea-karsinogenesen er et kompleksfenomen som bare delvis er tilgjengelig for vitenskapelig forskning.

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Study of distribution and interaction of arsenic and selenium in rat thyroid

Cited by 44 publications

References 16 publications

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning

Effect of long-term administration of arsenic (III) and bromine with and without selenium and iodine supplementation on the element level in the thyroid of rat

The Norwegian Thyroid Cancer Project: History, achievements and present view on carcinogenesis

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