Study of freeze-dried quercetin–cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis

Tayade, Pralhad; Rajendrakumar, Kale

doi:10.1016/s0731-7085(03)00529-6

Cited by 318 publications

(152 citation statements)

References 13 publications

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“…Also, to increase the bioavailability of this poorly water soluble compound, drug loaded solid lipid nanoparticles could be a promising alternative, and the complexation of quercetin with lecithin and cyclodextrin in aqueous solution has been tested [9,10]. Li et al [11] produced lecithin encapsulated quercetin by emulsification and low-temperature solidification, with over 90% drug entrapment efficiency in spherical particles of an average diameter of 155 nm was observed.…”

Section: (Figure 1)mentioning

confidence: 99%

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Lévai

Martín

Paz

et al. 2015

The Journal of Supercritical Fluids

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Quercetin is a flavonoid with highly promising bioactivity against a variety of diseases, due to its strong antioxidant, antiviral and antihistaminic effect, but these applications are limited by the low solubility of quercetin in gastrointestinal fluids and the correspondingly low bioavailability. The objective of this work is to produce encapsulated quercetin particles in sub-micrometric scale, in order to increase their low bioavailability. These particles were produced by extraction of organic solvent from oil in water emulsions by Supercritical Fluid Extraction of Emulsions (SFEE). Due to the rapid extraction of organic solvent by this method, the disperse organic phase becomes rapidly supersaturated, causing the precipitation of quercetin particles in sub-micrometric scale, encapsulated by the surfactant material. Two different biopolymers (Pluronic L64 ® poloxamers and soy bean lecithin) were used as carriers and surfactant materials. In experiments with Pluronic, needle quercetin particles were obtained after SFEE treatment, with particle sizes around 1 µm and poor encapsulation efficiency. In case of soy lecithin, quercetin-loaded multivesicular liposomes were obtained, with a mean particle size around 100 nm and around 70% encapsulation efficiency of quercetin, without presence of segregated quercetin crystals.

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Section: (Figure 1)mentioning

confidence: 99%

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Lévai

Martín

Paz

et al. 2015

The Journal of Supercritical Fluids

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“…The formation of inclusion complex can be confirmed by X-ray diffractometry [11,12]. The Figure2 shows the powder X-ray diffraction spectra of β-CD, , SA and SA:β-CD solid complex.…”

Section: Powder X-ray Diffraction Spectramentioning

confidence: 79%

Salicylanilide /Cyclodextrin Inclusion Complex: Preparation, Characterization and Molecular Docking Studies

Sivakumar¹

2015

SOJMSE

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“…[34][35][36] The absence or the presence of the melting point of organic compounds in their free or complex form could be used to confirm the formation of the inclusion complex within fiber mats. 33 Figure 2 shows that pure AC powder exhibited a broad endothermic peak over a temperature range of 40 to 160 o C, associating with the loss of moisture during the heating process, and a melting peak at about 248 o C, corresponding to the melting point of pure AC.…”

Section: Resultsmentioning

confidence: 99%

Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

Panichpakdee¹,

Pavasant²,

Supaphol³

2014

Polymer Korea

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Cellulose acetate (CA) fiber mats containing inclusion complexes of asiaticoside (AC) in 2-hydroxypropyl-β-cyclodextrin (HPβCD) for potential usage as wound dressings were developed. The AC/HPβCD complex-loaded CA fibers at various HPβCD to AC molar ratios of 0.5, 1, and 2 were prepared in 90:10 v/v mixture of 80% (v/v) acetic acid and N,N-dimethylacetamide (DMAc) via electrospinning. The maximum released amounts of AC depended on the HPβCD content and were much greater than those released from the AC-loaded CA fiber mat. In the in vitro study, indirect cytotoxic evaluation with human dermal fibroblasts (HDFa) showed that these materials released no substances in the levels that were harmful to the cells and the cells appeared to attach and proliferate well on these substrates. However, only the CA fiber mats containing AC/HPβCD complexes at the HPβCD to AC molar ratio of 0.5 was effective in upregulating the production of collagen of the cultured cells.

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Study of freeze-dried quercetin–cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis

Cited by 318 publications

References 13 publications

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Production of stabilized quercetin aqueous suspensions by supercritical fluid extraction of emulsions

Salicylanilide /Cyclodextrin Inclusion Complex: Preparation, Characterization and Molecular Docking Studies

Electrospinning of Asiaticoside/2-Hydroxypropyl-β-cyclodextrin Inclusion Complex-loaded Cellulose Acetate Fiber Mats: Release Characteristics and Potential for Use as Wound Dressing

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