Study of immunological dysfunction in periparturient Holstein cattle selected for high and average milk production

Detilleux, Johann; Kehrli, Marcus E.; Stabel, Judith R.; Freeman, A.E.; Kelley, David H.

doi:10.1016/0165-2427(94)05302-9

Cited by 131 publications

(76 citation statements)

References 33 publications

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“…The observed decrease in cellular CL in early lactation cows is in accordance with other studies [5,6,11,13,14]. Moreover, a significant positive correlation (r = 0.50; P < 0.001) was found between overall killing and PMA-stimulated CL [13].…”

Section: % Overall Killing % Overall Killingsupporting

confidence: 92%

Effect of milk sampling techniques on milk composition, bacterial contamination, viability and functions of resident cells in milk

et al. 2001

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-Three different milk sampling techniques were evaluated during milk sampling: a direct aseptic collection from the udder through a sterile cannula was used as the reference technique, compared with either a manual or a mechanical sampling method. In this study 30 high-yielding HolsteinFriesian dairy cows at different stages of lactation and free of udder infection were used. For each milk sample, the influence of milk sampling techniques was determined for the following parameters: somatic cell count, milk composition, bacterial contamination, viability, in vitro phagocytosis and overall killing of Staphylococcus aureus Newbould 305, and cellular chemiluminescence. Because milk sampling occurred throughout lactation, the differences between early, mid-and late lactation were estimated. It was concluded that bacterial contamination was not significantly different in manual milking samples and the reference technique; bacterial contamination was, however, significantly (P < 0.001) higher in machine milking samples than in the reference technique. Among the different sampling techniques, no significant effects on SCC, milk composition, viability and functions of the cells isolated from milk were observed. It was found that viability, intracellular killing and cellular chemiluminescence of milk PMN were significantly lower (P < 0.05) in early lactation compared to mid-lactation. Phagocytosis was significantly (P < 0.05) higher in early lactation compared to mid-and late lactation, and no significant differences were observed between mid-and late lactation. From this study, it can be concluded that despite a higher bacterial contamination obtained with the mechanical sampling method, the 3 milk sampling techniques described in this study can be used for the evaluation of milk cell functions. dairy cow / milk sampling technique / stage of lactation / milk composition / milk neutrophil functions Vet. Res. 32 (2001) 565-579 565

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Section: % Overall Killing % Overall Killingsupporting

confidence: 92%

Effect of milk sampling techniques on milk composition, bacterial contamination, viability and functions of resident cells in milk

et al. 2001

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“…Several studies have identified potential mechanisms associated with the impairment of the cellular immune function by increased media concentrations of ketones (Franklin et al, 1991;Detilleux et al, 1995). Chemotactic capabilities (Suriyasathaporn et al, 1999) and respiratory burst activity (Hoeben et al, 1997) are reduced in bovine blood PMN when supplemented with BHBA in vitro.…”

Section: Ketonesmentioning

confidence: 99%

Nutrition, immune function and health of dairy cattle

Ingvartsen

Moyes

2013

Animal

267

214

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The large increase in milk yield and the structural changes in the dairy industry have caused major changes in the housing, feeding and management of the dairy cow. However, while large improvements have occurred in production and efficiency, the disease incidence, based on veterinary records, does not seem to be improved. Earlier reviews have covered critical periods such as the transition period in the cow and its influence on health and immune function, the interplay between the endocrine system and the immune system and nutrition and immune function. Knowledge on these topics is crucial for our understanding of disease risk and our effort to develop health and welfare improving strategies, including proactive management for preventing diseases and reducing the severity of diseases. To build onto this the main purpose of this review will therefore be on the effect of physiological imbalance (PI) on immune function, and to give perspectives for prevention of diseases in the dairy cow through nutrition. To a large extent, the health problems during the periparturient period relate to cows having difficulty in adapting to the nutrient needs for lactation. This may result in PI, a situation where the regulatory mechanisms are insufficient for the animals to function optimally leading to a high risk of a complex of digestive, metabolic and infectious problems. The risk of infectious diseases will be increased if the immune competence is reduced. Nutrition plays a pivotal role in the immune response and the effect of nutrition may be directly through nutrients or indirectly by metabolites, for example, in situations with PI. This review discusses the complex relationships between metabolic status and immune function and how these complex interactions increase the risk of disease during early lactation. A special focus will be placed on the major energetic fuels currently known to be used by immune cells (i.e. glucose, non-esterified fatty acids, beta-hydroxybutyrate and glutamine) and how certain metabolic states, such as degree of negative energy balance and risk of PI, contribute to immunosuppression during the periparturient period. Finally, we will address some issues on disease prevention through nutrition.

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“…catecholamines and glucocorticoids, at parturition and during the first weeks of lactation has been related to the observed dysfunction of the immune system, and thus to the increased susceptibility of cattle to undergo infectious diseases such as mastitis (77,82,90,91). Indeed, the incidence to clinical mastitis in dairy cows is highest during these periods of abnormal hormonal balance (16,96).…”

Section: Introductionmentioning

confidence: 99%

Sympathoadrenal and immune system activation during the periparturient period and their association with bovine coliform mastitis. A review

Diez-Fraile

Meyer²,

Burvenich³

2003

Veterinary Quarterly

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Study of immunological dysfunction in periparturient Holstein cattle selected for high and average milk production

Cited by 131 publications

References 33 publications

Effect of milk sampling techniques on milk composition, bacterial contamination, viability and functions of resident cells in milk

Effect of milk sampling techniques on milk composition, bacterial contamination, viability and functions of resident cells in milk

Nutrition, immune function and health of dairy cattle

Sympathoadrenal and immune system activation during the periparturient period and their association with bovine coliform mastitis. A review

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