Study of insulin levels in hypothyroidism patients

Rajeswari, G. K.; Gopal, Pasagadugula Satya; Srinivas, Pasagadugula Satya; Suresh, Eadala

doi:10.18203/2320-6012.ijrms20150316

Cited by 5 publications

(8 citation statements)

References 10 publications

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“…In the present study we have explored the possible linkage among TSH, insulin resistance and serum total cholesterol in newly diagnosed hypothyroidism patients [47,48]. In this study total cholesterol are 233.66 ± 63.46 highly significantly elevated, compared to 222 ± 53 mg/dl in on study done by Guddanti Rajeswari et al in hypothyroidism pateients [49].…”

Section: Methodsmentioning

confidence: 74%

A Hospital-based Study for Clinico-investigative Profile of Newly Diagnosed Patients of Hypothyroidism

Thakur¹

2019

Endocrinol Metab Syndr

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Introduction: Hypothyroidism in adults has an insidious onset with a range of non-specific symptoms resulting in delayed diagnosis. Hypothyroidism is characterized by a broad clinical spectrum ranging from an overt state of myxedema, end-organ effects and multisystem failure to an asymptomatic or subclinical condition with normal levels of thyroxine and triiodothyronine and mildly elevated levels of serum thyrotropin. Thyroid dysfunction leads to altered glucose and lipid metabolism leading to insulin resistance, which is an important risk factor for cardio vascular diseases. This study attempts to study clinical and biochemical profile of patients with subclinical hypothyroidism or overt hypothyroidism. Aim of study:To study clinical and investigative profile of hypothyroidism in the newly diagnosed patients of hypothyroidism.Methods: All newly diagnosed hypothyroidism patients fulfilling inclusion and exclusion criteria were taken in to study. Demographic profile of all enrolled patients was recorded. They were subjected to detailed history and examination and the findings were recorded as a predesigned Performa. The clinical diagnosis of hypothyroidism was made as per Indian thyroid society guidelines. The following laboratory investigations were performed: serum lipid profile and serum uric acid using enzymatic assay, fasting insulin, creatinine, direct bilirubin, and the following liver function parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT). Thyroid-hormone profile, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), including anti-thyroid peroxidase (TPO). Observation and results:Between October 1, 2015 and September 30, 2016, 226 patients with newly diagnosed hypothyroidism were studied. Out of 226 patients, 48 patients excluded from the study. Central hypothyroidism was present in 4 patients and 44 were pregnant and lactating women. 178 patients with newly diagnosed hypothyroidism were enrolled in study. Out of 178 patients' subclinical hypothyroidism was present in 29(16.9%) patients. Out of 178 patients, 131 (73.6%) were females and 47 (26.4%) were males and various parameters were studied. Conclusion:Our study confirms that dyslipidemia, insulin resistance and metabolic syndrome correlate positively with newly diagnosed hypothyroid patients.

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Section: Methodsmentioning

confidence: 74%

A Hospital-based Study for Clinico-investigative Profile of Newly Diagnosed Patients of Hypothyroidism

Thakur¹

2019

Endocrinol Metab Syndr

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“…In a study done by Singh et al [8] in year 2010 found that TSH levels were positively correlated with serum insulin levels with significant P value<0.01. In one another study done by Rajeswari et al [9] in year 2015 found that TSH levels were positively correlated with insulin in patients with subclinical hypothyroidism (SCH). There study indicated that insulin resistance was present not only in overt hypothyroidism but it was significantly present in subclinical hypothyroidism also.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Thyroid Function in Patients of Type 2 Diabetes Mellitus without Nephropathy and Type 2 Diabetes Mellitus With Nephropathy

Sharma¹,

Sharma²,

Puri³

et al. 2017

AIMDR

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Background: Diabetes Mellitus is an important health problem affecting major population worldwide. It is characterized by absolute or relative deficiency in insulin secretion and/or insulin action associated with chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. The prevalence of type II diabetes mellitus for all age groups worldwide was estimated to be 2.8% in 2000 and likely to increase to 4.4% in 2030. The number of people with diabetes is projected to rise from 285 million adults in 2010 to 439 million adults in 2030. In India, it is estimated that presently 31.7 million individuals are affected by this deadly disease, which are likely to increase to 79.4 million by the year 2030. Diabetes patients with nephropathy have higher prevalence of thyroid disorder than type 2 DM without nephropathy which may have an influence on diabetic management. Diabetic women are frequently affected than men and hypothyroidism is more common than thyrotoxicosis. Methods: In our study 100 patients with type 2 DM attending Guru Nanak Dev hospital attached to GMC Amritsar were recruited. These patients were divided into two groups of 50 patients each. Group 1 consisted of patients of type 2 DM without nephropathy and group 2 consisted of patients of type 2 DM with nephropathy. Results: Out of 100 patients thyroid dysfunction was more prevalent in diabetic nephropathy group as compared to diabetic without nephropathy group. P-value for thyroid dysfunction in diabetic nephropathy was statistically significant. In our study we found a statistically significant correlation between TSH and serum insulin levels in patients with diabetic and diabetic nephropathy. Higher prevalence of thyroid dysfunction like low T3 syndrome and subclinical hypothyroidism was found in women as compared to men. Conclusion: Routine assessment of thyroid hormone level in addition to other biochemical parameters in the early stage of diabetes and diabetes nephropathy will help in the management of those patients who are difficult to manage.

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“…In one another study done by Rajeswari G. et al in year 2015 found that TSH levels were positively correlated with insulin in patients with subclinical hypothyroidism(SCH). [23] Their study indicated that insulin resistance was present not only in overt hypothyroidism but it was significantly present in subclinical hypothyroidism also. In our study in group 1 there were 14(28%) males, 36(72%) females, mean age of patients was 56.86±9.689 and 21(42%) were hypertensive.…”

Section: Discussionmentioning

confidence: 99%

Study of Insulin Levels in Patients of Type 2 DM With and Without Nephropathy and Thyroid Disorders

Singh¹,

Aloona²,

Neki³

2017

AIMDR

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Background: Thyroid disorders are established risk factor for insulin resistance. In this study we find out whether association exists between insulin resistance in type 2 diabetes patients with and without nephropathy and thyroid disorders. Methods: Serum T3 T4 TSH, fasting and postprandial blood sugar, HbA1c, serum insulin levels, serum creatinine, and urinary albumin creatinine ratio were estimated in 100 patients with type 2 DM. These patients were divided into two groups of 50 patients, Group 1-type 2 DM without nephropathy and Group 2-type 2 DM with nephropathy. Results: In our study we found a statistically significant correlation between TSH and serum insulin levels in patients with diabetic and diabetic nephropathy. Out of 100 patients thyroid dysfunction was more prevalent in diabetic nephropathy group as compared to diabetic without nephropathy group. P-value for thyroid dysfunction in diabetic nephropathy was statistically significant. In present study higher prevalence of thyroid dysfunction in women as compared to men. Conclusion: Routine assessment of thyroid hormone level in addition to other biochemical parameters in the early stage of diabetes and diabetes nephropathy will help in the management of those patients whose condition are difficult to manage.

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Study of insulin levels in hypothyroidism patients

Cited by 5 publications

References 10 publications

A Hospital-based Study for Clinico-investigative Profile of Newly Diagnosed Patients of Hypothyroidism

A Hospital-based Study for Clinico-investigative Profile of Newly Diagnosed Patients of Hypothyroidism

A Comparative Study of Thyroid Function in Patients of Type 2 Diabetes Mellitus without Nephropathy and Type 2 Diabetes Mellitus With Nephropathy

Study of Insulin Levels in Patients of Type 2 DM With and Without Nephropathy and Thyroid Disorders

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