Study of interactions between hyaluronan and cationic surfactants by means of calorimetry, turbidimetry, potentiometry and conductometry

Krouská, Jitka; Pekař, Miloslav; Klučáková, Martina; Šarac, Bojan; Bešter‐Rogač, Marija

doi:10.1016/j.carbpol.2016.11.069

Cited by 13 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The second energetic contribution found in the [G-C18:1+PLL] system is nonspecific (Δ H 2 > 0), and it corresponds to the clustering, or grouping, of the nonpolar tails of G-C18:1 molecules, driven by the release of water ( T Δ S 2 > 0). Similar coexisting specific and nonspecific interactions were reported in the hyaluronan/cationic vesicle system or gum acacia/bovine serum albumin system and are well-known in polyelectrolyte–micelle coacervation (“polymer-driven micellization”) …”

Section: Resultssupporting

confidence: 76%

Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates

et al. 2020

View full text Add to dashboard Cite

Polyelectrolyte-surfactant complexes (PESCs) are important soft colloids with applications in the field of personal care, cosmetics, pharmaceutics and much else. If their phase diagrams have long been studied under pseudo-equilibrium conditions, and often inside the micellar or vesicular regions, understanding the effect of non-equilibrium conditions, applied at phase boundaries, on the structure of PESCs generates an increasing interest. In this work we cross the micelle-vesicle and micelle-fiber phase boundaries in an isocompositional surfactantpolyelectrolyte aqueous system through a continuous and rapid variation of pH. We employ two microbial glycolipid biosurfactants in the presence of polyamines, both systems being characterized by their responsiveness to pH. We show that complex coacervates (Co) are always formed in the micellar region of both glycolpids' phase diagram and that their phase behaviour drives the PESCs stability and structure. However, for glycolipid forming single-wall vesicles, we observe an isostructural and isodimensional transition between complex coacervates and a multilamellar walls vesicle (MLWV) phase. For the fiber-forming glycolipid, on the contrary, the complex coacervate disassembles into free polyelecrolyte coexisting with the equilibrium fiber phase. Last but not least, this work also demonstrates the use of microbial glycolipid biosurfactants in the development of sustainable PESCs.

show abstract

Section: Resultssupporting

confidence: 76%

Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Other forces related to the exothermic behavior of the interactions could also be hydrogen bonds and hydrophobic interactions. Similar exothermic behavior was found for the interactions of positively charged micelles with hyaluronan …”

Section: Results and Discussionsupporting

confidence: 75%

“…Similar exothermic behavior was found for the interactions of positively charged micelles with hyaluronan. 31 The results of isothermal titrations at 25 °C for all molecular weights of hyaluronan are summarized in Figure 5. These data points, which are nicely ordered in a line with a breakpoint, were obtained by the integration of every peak area of the ITC injection where the following enthalpy value is added to the previous one.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Another suitable method, which allows the characterization of interaction and binding is isothermal titration calorimetry (ITC) . It was used to determine the thermodynamic characteristics of macroscopic aggregation in the system of polyelectrolyte and oppositely charged surfactant, hyaluronan, and two types of surfactants tetradecyltrimethylammonium bromide (TTAB) and hexadecyltrimethylammonium bromide (HTMAB), respectively. , The ITC study of the binding mechanism in the system of neutralized poly(acrylic acid) and methacrylic acid/ethyl acrylate copolymers and dodecyltrimethylammonium bromide was performed. , Therefore, the ITC method was chosen also for the characterization of IPA systems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

et al. 2021

View full text Add to dashboard Cite

High-resolution ultrasound spectroscopy (HR-US), size and ζpotential titrations, and isothermal titration calorimetry (ITC) were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles composed of hexadecyltrimethylammonium-dodecylsulphate (HTMA-DS), dioctadecyldimethylammonium chloride (DODAC), and cholesterol. In addition to these methods, visual observations were performed with the selected molecular weight of hyaluronan. A very good correlation was obtained between data from size titration, HR-US, and visual observation, which indicated in lower charge ratios the formation of hyaluronan-coated vesicles. On the contrary, at higher charge ratios, coated vesicles disintegrated to a size of around 2000 nm. The intensity of these interactions and the disaggregation were dependent on the molecular weight of hyaluronan. All interactions studied by ITC showed strong exothermic behavior, and these interactions between vesicles and hyaluronan were confirmed from the first addition, independently of the molecular weight of hyaluronan.

show abstract

“…A rendszerükön végzett mérések alapján a kritikus aggregációs koncentráció (cac) 1:1 körüli töltési arányok beállta esetében figyelhető meg. Ezt egy későbbi publikációjukkal még inkább megerősítették[140]. Azonban fontos megjegyezni, hogy az eredményeiket cmc feletti koncentrációknál kapták, ahol a micellák képződése jelentősen befolyásolhatja az adatokat.…”

unclassified

Makromolekulás kolloidokból felépülő hatóanyag hordozó rendszerek tervezése

Varga

View full text Add to dashboard Cite

Kutatócsoportunkban már néhány éve kiemelt figyelmet kap főként szérum fehérje alapú hatóanyag hordozó kolloid részecskék előállítása, ahol idegtudományi kutatásokban releváns, neuroaktív hatással rendelkező vegyületek vér-agy gáton való transzportjának megvalósítása a cél. Ezen kutatásokhoz kapcsolódtam 2017. őszén, ahol egy újonnan elnyert GINOP-2.3.2 pályázat keretein belül, kiemelt feladatom volt új típusú, főként polimer és poliszacharid alapú hatóanyaghordozó rendszerek tervezése és reprodukálható szintézisek kidolgozása. Célul tűztük ki főként PLA, PLGA és hialuronsav (HyA) alapú makromolekulás kolloidokból felépülő hordozó rendszerek kialakítását, ahol tanulmányozni kívántuk a hordozó rendszerek hidrofilitásának, szerkezetének, felületi töltésének a modellként alkalmazott hidrofil vagy hidrofób, aromás, vagy csak alifás csoportokat tartalmazó, töltéssel rendelkező vagy semleges kismolekulák kapszulázási hatékonyságára gyakorolt hatását. Meghatározni kívántuk, hogy a képződő részecskék méretét, szerkezetét, morfológiáját milyen kísérleti tényezők befolyásolják. Ahol arra lehetőség adódott, a hatóanyag felszabadulás kinetikáját is tanulmányozni kívántuk.

show abstract

Study of interactions between hyaluronan and cationic surfactants by means of calorimetry, turbidimetry, potentiometry and conductometry

Cited by 13 publications

References 31 publications

Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates

Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Makromolekulás kolloidokból felépülő hatóanyag hordozó rendszerek tervezése

Contact Info

Product

Resources

About