Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy

Shelbaya, Salah; Shady, Manal Mohamed Abu; Nasr, Merhan Samy; Bekhet, Miram M.; Mageed, Yasmine Abd-Al; Abbas, Magdy

doi:10.2174/1573399813666170829163442

Cited by 36 publications

(27 citation statements)

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“…Additionally, the Moreno-Navarrete et al [ 54 ] study showed that plasma levels of irisin and the expression of the FNDC5 gene in muscle and fat tissue in obese patients with type 2 diabetes and obesity are reduced. Very similar results were obtained by Shelbaya et al [ 55 ]. In addition to the lower concentration of irisin in the blood of patients with type 2 diabetes compared to healthy people, they revealed the negative correlations with creatinine, systolic, and diastolic blood pressure, BMI, ACR, and HbA1c [ 55 ].…”

Section: Discussionsupporting

confidence: 91%

“…Very similar results were obtained by Shelbaya et al [ 55 ]. In addition to the lower concentration of irisin in the blood of patients with type 2 diabetes compared to healthy people, they revealed the negative correlations with creatinine, systolic, and diastolic blood pressure, BMI, ACR, and HbA1c [ 55 ]. Bonfante et al [ 56 ] found in their research that a higher level of irisin is associated with a better metabolic profile of obese people.…”

Section: Discussionsupporting

confidence: 91%

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The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

et al. 2020

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The quantitative analysis of selected regulatory molecules, i.e., adropin, irisin, and vaspin in the plasma of obese patients with newly diagnosed, untreated type 2 diabetes mellitus, and in the same patients after six months of using metformin, in relation to adropinemia, irisinemia and vaspinemia in obese individuals, was performed. The relationship between plasma concentration of the adipocytokines/regulatory peptides and parameters of renal function (albumin/creatinine ratio—ACR, estimated glomerular filtration rate—eGFR), values of insulin resistance indicators (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR2), Homeostatic Model Assessment of Insulin Sensitivity (HOMA-S), Homeostatic Model Assessment of β-cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI), insulin), and parameters of carbohydrate-lipid metabolism (fasting plasma glucose—FPG, glycated hemoglobin—HbA1C, estimated glucose disposal rate—eGDR, fasting lipid profile, TG/HDL ratio) in obese type 2 diabetic patients was also investigated. Circulating irisin and vaspin were found significantly different in subjects with metabolically healthy obesity and in type 2 diabetic patients. Significant increases in blood levels of both analyzed adipokines/regulatory peptides were observed in diabetic patients after six months of metformin treatment, as compared to pre-treatment levels. The change in plasma vaspin level in response to metformin therapy was parallel with the improving of insulin resistance/sensitivity parameters. An attempt was made to identify a set of biochemical tests that would vary greatly in obese non-diabetic subjects and obese patients with type 2 diabetes, as well as a set of parameters that are changing in patients with type 2 diabetes under the influence of six months metformin therapy, and thus differentiating patients′ metabolic state before and after treatment. For these data analyses, both statistical measures of strength of the relationships of individual parameters, as well as multidimensional methods, including discriminant analysis and multifactorial analysis derived from machine learning methods, were used. Adropin, irisin, and vaspin were found as promising regulatory molecules, which may turn out to be useful indicators in the early detection of T2DM and differentiating the obesity phenotype with normal metabolic profile from T2DM obese patients. Multifactorial discriminant analysis revealed that irisin and vaspin plasma levels contribute clinically relevant information concerning the effectiveness of metformin treatment in T2D patients. Among the sets of variables differentiating with the highest accuracy the metabolic state of patients before and after six-month metformin treatment, were: (1) vaspin, HbA1c, HDL, LDL, TG, insulin, and HOMA-B (ACC = 88 [%]); (2) vaspin, irisin, QUICKI, and eGDR (ACC = 86 [%]); as well as, (3) vaspin, irisin, LDL, HOMA-S, ACR, and eGFR (ACC = 86 [%]).

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

et al. 2020

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“…The reduction in irisin level has been detected in stage 5 of CKD, although the reduction in muscle mass and/or the significant reduction in renal function may affect irisin levels. Nevertheless, substantial reduction was observed in diabetic nephropathy patients [ 167 ]. Recently, reduction in FNDC5 expression was significantly associated to enhanced SkM autophagy and atrophy under urotensin II (UII) induction in vivo in a mouse model of CKD and in vitro in C2C12 cells.…”

Section: Fndc5/irisin and Autophagymentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

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Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular proteins and organelles. This process is a part of the molecular underpinnings by which exercise promotes healthy aging and mitigate age-related pathologies. Irisin is a myokine released during physical activity and acts as a link between muscles and other tissues and organs. Its main beneficial function is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin modulates metabolic processes, acting on glucose homeostasis, reduces systemic inflammation, maintains the balance between resorption and bone formation, and regulates the functioning of the nervous system. Recently, some of its pleiotropic and favorable properties have been attributed to autophagy induction, posing irisin as an important regulator of autophagy by exercise. This review article proposes to bring together for the first time the “state of the art” knowledge regarding the effects of irisin and autophagy. Furthermore, treatments on relation between exercise/myokines and autophagy have been also achieved.

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“…It has previously been shown that irisin mitigates expression of pro-inflammatory cytokines, to reduce oxidative stress and to possess anti-apoptotic effects [3]. In patients with diabetes mellitus, irisin levels were lower with regard to their non-diabetic counterparts and circulating levels were even more decreased when the disease was accompanied by other co-morbidities such as diabetic nephropathy [19,34]. Moreover, reduced levels of irisin were supposed to be related to diabetes mellitus and other metabolic diseases [33].…”

Section: Introductionmentioning

confidence: 99%

Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients

et al. 2019

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Irisin is a myokine involved in adipocyte transformation. Its main beneficial effects arise from increased energy expenditure. Irisin production is particularly stimulated by physical exercise. The present study investigates the changes of plasma irisin in type 2 diabetic patients performing 2 different training modalities. Fourteen type 2 diabetic patients underwent 4 week of supervised high-intensity interval training (HIT; n=8) or continuous moderate-intensity training (CMT; n=6), with equivalent total amounts of work required. Plasma samples were collected in the resting state atbaseline and one day after the exercise intervention to analyse resting plasma irisin, blood lipids, blood glucose, hsCRP, Adiponectin, Leptin and TNF-α concentrations. In addition, body composition and VO2peak were determined Resting plasma irisin increased after HIT (p=0.049) and correlated significantly with plasma fasting glucose at follow-up (r=0.763; p=0.006). CMT did not significantly change the amount of plasma irisin, although follow-up values of plasma irisin correlated negatively with fat-free mass (r=−0.827, p=0.002) and with fasting plasma glucose (r = − 0.934, p=0.006). Plasma irisin was found to increase with higher training intensity, confirming the assumption that exercise intensity, in addition to the type of exercise, may play an important role in the stimulation of the irisin response.

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Study of Irisin Hormone Level in Type 2 Diabetic Patients and Patients with Diabetic Nephropathy

Abstract: There is a decrease in serum irisin level in type 2 diabetic patients with even more significant reduction in patients with diabetic nephropathy.

Cited by 36 publications

References 0 publications

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

Irisin and Autophagy: First Update

Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients

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