Study of Ki-67 Immunostaining in Breast Carcinoma and it’s Correlation with Grade of Tumor and Lymph Node

Abstract

Background: Breast cancer is the commonest cancer in women worldwide and represents a disease with wide spectrum particularly in terms of tumour histology, biology, prognosis and response to therapy. Breast cancer is characterized by cellular heterogeneity. Methods: The study was conducted in the Department of Pathology, GSVM Medical College, Kanpur and associated hospital of Kanpur from January 2018 to September 2019 on patients of breast carcinoma. These cases were selected from the outpatient and inpatient of LLR Hospital, Kanpur, India. In the present study, we had taken a total of 80 cases of invasive breast carcinoma as well as Histomorphology, Ki-67 immunostaining and it's a correlation with lymph node status and tumour grade were studied. Results: This study leads us to conclude that the peak incidence of invasive breast carcinoma was reported in the age group of 41 to 50 years (with mean age 47.32 year and the standard deviation was 11.63). In the present study, the most common histological type was invasive ductal carcinoma, not otherwise specified (NOS). In our study, 66.25% of cases had metastatic lymph nodes and half of them were having more than 4 metastatic lymph node. In the grade-II of Bloom Richardson Grading system, there were 40% cases and in grade-III there were 35% of cases and grade-I has shown 25% of cases. A significant association was found between the grade of the tumor and the lymph node positivity. Conclusion: The present study concluded a positive correlation between the grade of tumour and Ki-67 immunohistochemistry, which was used as a prognostic and predictive parameter.