Study of prostatic pathology and its correlation with prostate specific antigen level

Hirachand, S; Dangol, Ums; Pradhanang, S; Acharya, S

doi:10.3126/jpn.v7i1.16911

Cited by 16 publications

(28 citation statements)

References 10 publications

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“…Prostatits was seen in 5.5% cases and 71% of prostatitis had PSA range of 0-7 ng/ml. 10 Benerjee B et al also showed that BPH, BPH with prostatitis and only prostatitis were seen in 38.8%, 28.75% and 7.5% cases respectively and all these benign cases had PSA range of 0-7 ng/ml. 1 Similarly other studies also showed that PSA level is usually < 20 ng/ ml in case of benign conditions like BPH.…”

Section: Discussionmentioning

confidence: 92%

“…1,2,6 A study done in Kathmandu valley showed that the maximum number of patients with prostatic disease was seen in 61-70 years age group. 10 There were 36 cases (70.6%) of BPH with maximum number of cases in age group 60-69 years. There was no case of BPH in patient less than 40 years and only 5.6% cases in age group 40-49 years.…”

Section: Discussionmentioning

confidence: 95%

“…Similar finding was seen in several other studies. 10,12,15 In a study done by Sridevi N et al, all the cases of carcinoma prostate showed significant elevation of PSA > 20 ng/ml. 16 All the cases of carcinoma prostate were adeno carcinoma.…”

Section: Discussionmentioning

confidence: 95%

“…2,13 Other studies showed 10% and 10.2% cases of PIN where PSA level was <14ng/ ml. 1,10 Study had suggested that HGPIN is associated with carcinoma and usually if it is so the incidence of HGPIN is high as 78.9 -88%. 14,15 However, in our study there was no HGPIN associated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences. Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings. Results: A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml. Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

2019

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“…1 The incidence of prostatic lesions increases with increasing age. 2,3 The most important diseases of prostate are inflammatory lesions (Prostatitis), nodular hyperplasia (Benign prostatic hyperplasia) and carcinoma. 1,2,4 Prostatic carcinoma is the second most common cancer and the sixth leading cause of cancer deaths in males.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Prostatic Lesions in a Tertiary Care Hospital- A 5½-Year Retrospective Descriptive Study

Satyasri¹,

Sinha²,

S³

2018

jemds

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BACKGROUND The incidence of prostatic lesions increases with increasing age. The most important diseases of prostate are inflammatory lesions (prostatitis), nodular hyperplasia (benign prostatic hyperplasia) and carcinoma. Prostatic carcinoma is the second most common cancer in males. Prostatic cancer is usually diagnosed histopathologically based on morphological features like growth pattern, nuclear atypia and absence of basal cells. Establishing or ruling out the diagnosis of carcinoma of prostate has been a challe nging task for pathologists for many years. MATERIALS AND METHODS The present study was a retrospective descriptive study for all the prostatic specimens received between January 2013 and June 2018. The haematoxylin and eosin stained slides were retrieved and reviewed. RESULTS The present study constituted a total of 321 cases with age ranging from 30 years-85 years. All prostatic specimens were broadly classified into non-neoplastic and neoplastic lesions. The present study included 321 prostatic specimens which comprised of 02 prostatic biopsies, 318 Transurethral Resection of Prostate (TURP) chips and 01 prostatectomy specimens. Out of total 321 cases, non-neoplastic were 279 cases (86.91%) and neoplastic were 42 (13.09%) cases. Most common non-neoplastic lesion was nodular hyperplasia 278 cases, of which 117 cases were affected by prostatitis. Out of total nodular hyperplasia with prostatitis, 05 cases were showing granulomas and 112 cases were showing prostatitis (non-granulomatous). In the present study, neoplastic lesions were 42 cases, out of which low-grade Prostatic Intraepithelial Neoplasia (PIN) were 15 cases (37.7%), adenocarcinoma 25 cases (59.5%) and other neoplasms 02 cases (4.7%). CONCLUSION Our study concluded that Benign Prostatic Hyperplasia (BPH) is the commonest lesion among males with features of prostatism and most common type of inflammation associated with BPH is chronic inflammation. The commonest age group affected by both carcinoma and BPH is the seventh decade.

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Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

Davodabadi

Mirinejad

Fathi-karkan

et al. 2023

Biotechnology Progress

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Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various molecules, including amino acids, proteins, and pharmaceuticals. Through a series of adsorption, recovery, and amplification steps, Apts are extracted from combinatorial libraries of synthesized nucleic acids. Using aptasensors in bioanalysis and biomedicine can be improved by combining them with nanomaterials. Moreover, Apt‐associated nanomaterials, including liposomes, polymeric, dendrimers, carbon nanomaterials, silica, nanorods, magnetic NPs, and quantum dots (QDs), have been widely used as promising nanotools in biomedicine. Following surface modifications and conjugation with appropriate functional groups, these nanomaterials can be successfully used in aptasensing. Advanced biological assays can use Apts immobilized on QD surfaces through physical interaction and chemical bonding. Accordingly, modern QD aptasensing platforms rely on interactions between QDs, Apts, and targets to detect them. QD‐Apt conjugates can be used to directly detect prostate, ovarian, colorectal, and lung cancers or simultaneously detect biomarkers associated with these malignancies. Tenascin‐C, mucin 1, prostate‐specific antigen, prostate‐specific membrane antigen, nucleolin, growth factors, and exosomes are among the cancer biomarkers that can be sensitively detected using such bioconjugates. Furthermore, Apt‐conjugated QDs have shown great potential for controlling bacterial infections such as Bacillus thuringiensis, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, Campylobacter jejuni, Staphylococcus aureus, and Salmonella typhimurium. This comprehensive review discusses recent advancements in the design of QD‐Apt bioconjugates and their applications in cancer and bacterial theranostics.

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Study of prostatic pathology and its correlation with prostate specific antigen level

Cited by 16 publications

References 10 publications

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

Evaluation of Prostate specific antigen levels and its correlation with histopathological findings

Spectrum of Prostatic Lesions in a Tertiary Care Hospital- A 5½-Year Retrospective Descriptive Study

Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends

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