Study of pyridinium-type functional polymers. II. Antibacterial activity of soluble pyridinium-type polymers

Abstract

ABSTRACT:The antibacterial activity of a series of soluble pyridinium-type polymers with different compositions against Escherichia coli (E. coli ) suspended in sterilized distilled water was investigated by a colony count method. The results show that the antibacterial activity of the soluble pyridinium-type polymers is characterized by their activity to kill bacterial cells and this activity can be enhanced as the content of the pyridinium group ( C q ) in the polymers increases. The species of the bacteria has a great influence upon the antibacterial activity of the soluble pyridinium-type polymers. The polymers possess a strong ability to kill Gram-positive and Gram-negative bacteria, and yeasts, excepting Bacillus subtilis, having gemmae and fungi. The toxicity of this kind of polymer has also been appraised. In the acute stimulation and allergy experiments, the red maculae, edema, and abnormal phenomena of an allergy on the skin of the tested animals were not observed. The acute toxicity experiment shows that the LD 50 of the polymer is 2330 mg/kg, implying that this kind of polymer has only very weak toxicity. This is significant for the application of soluble pyridinium-type polymers.

Antimicrobial Ionic Liquids

“…Other studies have indicated that the mechanism of antimicrobial activity of ionic liquids is via membrane disruption. This seems likely given the structural similarity between ionic liquids and antimicrobial agents whose mechanism is more fully elucidated (Li et al, 1998;Pernak et al, 2001). Many ionic liquids have a similar structure to cationic surfactants whose primary mode of action membrane-bound protein disruption (Bernot et al, 2005).…”

Antibacterial and Hemolytic Activities of Quaternary Pyridinium Functionalized Polynorbornenes

“…[5] Polymers containing quaternary nitrogen functionalities have been commonly used as biocidal agents. [6][7][8][9][10][11][12][13][14][15] A number of polymeric disinfectants based on quaternary pyridinium groups, either in the backbone or as pendant groups, have been prepared, which show good activity against bacteria. Recently, Gao and coworkers synthesized random copolymers of acrylamide and vinyl pyridine of varying MWs and pyridine content, which were subsequently quaternized with dimethyl sulfate.…”

Study of modified polypropylene nonwoven cloth. II. Antibacterial activity of modified polypropylene nonwoven cloths

“…E. coli were incubated at 37°C for 24 h on a nutrient agar plate. Then, the bacterial cell suspensions were prepared as described before, 5 with sterile distilled water used as the suspending medium.…”

“…Along with increasing the filtration rate, it is unfavorable for samples to adsorb or adhere bacterial cells at a shorter contact time; therefore, the extent of removal is lower. Because there is a strong adherence between A 1 2.57 ϫ 10 5 5.05 ϫ 10 4 2.81 ϫ 10 3 4.23 ϫ 10 2 28 A 5 2.02 ϫ 10 4 5.03 ϫ 10 3 6 0 0 a N (inf.) , 5.61 ϫ 10 6 cells/mL; filtration rate, 7.5 mL/min; collected effluent bacterial volume, 20 mL.…”

“…Polymeric antibacterial agents offer great promise for enhancing the efficacy of some existing antibacterial agents as well as reducing the environmental problems associated with others. 5 But some polymeric antibacterial agents such as pyridinium resin are not suitable for some applied requirements, because of their low surface area, high cost, poor workability, and bad mechanical properties. To overcome these drawbacks, some researchers have already attempted to bear antibacterial agents onto polymeric matrixes.…”