Study of Reducing the Danger of T-2 Toxin When Using a Drug of Organomineral Origin

Abstract

The prevalence of microscopic fungi and their metabolites in food raw materials and agricultural products poses a great threat to the population. Many mycotoxins are highly toxic and resistant to various environmental factors. The drugs available on the market do not completely neutralize these toxins. The residues of toxins can pose a threat to farm animals, causing a violation in hematological, biochemical, reproductive indicators, a decrease in weight gain, a deterioration in the sanitary quality of meat, milk and eggs. The comparative studies of the T-2 toxin effect on the biological objects -protozoa and primary cell culture (Stylonychia mytilus and bull spermatozoa) indicate a selective toxic activity of this type mycotoxin. When protozoa exposed to T-2 toxin in a dose of 0.5 mcg/ml, cell death was 19 %. The corresponding figure for a germ cell culture was 34 %. The protective effect of exposure to T-2 toxin on biological models was observed with the use of all studied protective drugs. When using bentonite from the Apastovo deposit of RT, the decrease in the death of protozoa against the background of the influence of T-2 toxin was 15 % higher compared to the control. When using strains of microorganisms B. Subtilis and L. Plantarum together with T-2 toxin, the death of protozoa was 10 % higher than the control. The use of the drug KMBI-3 containing bentonite and strains of microorganisms B. Subtilis and L. Plantarum significantly reduced the toxic effects of T-2 toxin, both on protozoan cells and on primary germ cells. The drug KMBI-3 is a dry powder that has the potential to reduce phytopathogen toxins in food raw materials.