Study of Risk Factors for Esophageal Cancer in Khorramabad City From 2012 - 2014

Shamsifar, Soroush; Sepahvand, Saba; Rezapour, Sadegh; Adeli, Mahin

doi:10.17795/jjcdc-33229

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…14 In another case control study, Moradi and colleagues found that 21.6% of cases but no one in the control group had EC in their first degree relatives (OR=7.6, p =0.001). 15 Since the role of family history have genetic and environmental elements in the pathogenesis of EC, more studies should be considered. …”

Section: Introductionmentioning

confidence: 99%

Esophageal Cancer in Golestan Province, Iran: A Review of Genetic Susceptibility and Environmental Risk Factors

Gholipour¹,

Islami²,

Roshandel³

et al. 2016

Middle East J Dig Dis

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Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor that is typically diagnosed only when the tumor has gained remarkable size, extended to peripheral tissues, and led to dysphagia. Five-year survival of advanced cancer is still very poor (19%), even with improved surgical techniques and adjuvant chemoradiation therapy. Therefore, early detection and prevention are the most important strategies to reduce the burden of ESCC. Our review will focus on the studies conducted in Golestan province, an area with a high prevalence of ESCC in northern Iran. We review three aspects of the research literature on ESCC: epidemiological features, environmental factors (including substance abuse, environmental contaminants, dietary factors, and human papillomavirus [HPV]), and molecular factors (including oncogenes, tumor suppressor genes, cell cycle regulatory proteins, and other relevant biomarkers). Epidemiological and experimental data suggest that some chemicals and lifestyle factors, including polycyclic aromatic hydrocarbons (PAHs), cigarette smoking, opium use, and hot tea drinking are associated with the development of ESCC in Golestan. HPV infects the esophageal epithelium, but so far, no firm evidence of its involvement in esophageal carcinogenesis has been provided. Some of these factors, notably hot tea drinking, may render the esophageal mucosa more susceptible to injury by other carcinogens. There are few studies at molecular level on ESCC in Golestan. Increasing awareness about the known risk factors of ESCC could potentially reduce the burden of ESCC in the region. Further studies on risk factors, identifying high risk populations, and early detection are needed.

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Section: Introductionmentioning

confidence: 99%