Study of selective immunoglobulin A deficiency among Egyptian patients with food allergy

Abstract

Introduction: iga deficiency is one of the commonest primary antibody deficiencies. although many affected individuals could be asymptomatic, selected patients suffer from recurrent mucosal infections, allergies, and autoimmune diseases.Aim of the study: to investigate the prevalence of iga deficiency among egyptian patients with food allergy.Material and methods: we studied 100 patients (62 males, 38 females; mean age, 28.6 years) with multiple food allergies who were recruited on the basis of adequate immunological assessment by history, skin prick test, and confirmed by open challenge test as well as 50 healthy controls. measurement of levels of ige and iga using elisa technique were performed for all patients and controls.Results: deficiency of iga was detected in 67% of patients with food allergy. serum iga levels were significantly lower among patients with food allergy (67.3 μg/ml; range, 56.7-72.0 μg/ml) as compared to healthy control (78.6 μg/ml; range, 72.8-84 μg/ml). both iga and ige levels were not statistically different between patients with food allergy only and those with combined food and aeroallergen. among food allergic group, serum IgA levels were inversely correlated with serum IgE levels (r = -0.314, p < 0.001).Conclusions: manifestations of atopy, such as food allergy might be a present feature before diagnosis of primary immune deficiency diseases as iga deficiency.

Selective IgA Deficiency a Probable Risk of Recurrent Chest Infections in Asthmatics

“…However, their study was conducted on a population different from the population of the present study as they investigated the prevalence of IgA deficiency among Egyptian patients with food allergy. 24 Nonetheless, Kim et al disagreed with the current results regarding the correlation between serum IgA and serum IgE and age. They declared that serum IgE level was positively related to serum IgA level.…”

SIgA in various pulmonary diseases

“…Shahin et al have also reached a similar conclusion. They have revealed serum IgA level is correlated with serum IgE level, and the correlation is significantly negative [ 65 ]. Several studies have confirmed that serum IgE levels of asthmatic patients are elevated [ 66 , 67 ].…”

Gluten-free diet exposure prohibits pathobiont expansion and gluten sensitive enteropathy in B cell deficient JH-/- mice

“…The results from both of these studies suggest that a diminished humoral immune response enhances sensitivity to gluten. This is not without precedent, as humoral immunodeficiency has previously been shown to enhance immune responses to other dietary antigens in both mouse models [31][32][33] as well as humans [34][35][36][37]. From these observations we sought to determine how exposure to a gluten-free diet influences the microbiota and report several interesting findings.…”