Study of Structure of Colloidal Particles of Fullerenes in Water Solution

Water-Soluble Pristine C60 Fullerenes Inhibit Liver Fibrotic Alteration and Prevent Liver Cirrhosis in Rats

“…It turned out that the used C 60 FAS contains both single C 60 fullerene (objects with a height of 0.7 nm in Figure 2) and its labile nanoaggregates with a size of 1.3-70 nm. The majority of C 60 molecules were located chaotically and separately along the surface or in the form of bulk nanoclusters consisting of several tens of C 60 molecules [47] (objects with a height of 1.3-2 nm in Figure 2). Thus, the C 60 FAS applied in our experiments is a typical colloidal nanofluid.…”

Comparative Analysis of the Antineoplastic Activity of C60 Fullerene with 5-Fluorouracil and Pyrrole Derivative In Vivo

“…The found gyration radius of clusters, R g , is about 20 nm. For spherical homogeneous approximation in the case of C 60 FAS [6, 40, 42, 43], the C 60 fullerene nanoparticle size can be estimated as 2 × (5/3) 1/2  ×  R g , which gives the effective diameter about 52 nm.…”

“…It has long been established that the dissolution of pristine C 60 fullerene in water is due to the formation of solvation shell around the C 60 molecule tightly attached to it [5, 6, 43, 52, 53]. However, recent data have evidenced that the molecular dissolution of the C 60 fullerene in water, at least in part, is promoted by the attachment of a certain number of OH groups to the C 60 fullerene surface, i.e., the pristine C 60 fullerene in water becomes partially hydroxylated [7, 54].…”

“…The nearly spherical C 60 molecule (diameter is 0.72 nm) can currently be routinely synthesized and is characterized by high chemical stability and biological activity in vitro and in vivo [1–4]. C 60 fullerenes are soluble in nonpolar organic solvents [5] and can be transferred into the water by means of special procedures [6–8]. These properties enable fullerene to utilize in biological objects due to their ability to easily penetrate the cell lipid membrane [9–12].…”

Changing of dynamic response of the active muscle soleus in conditions of its ischemization in alcoholic rats when C60 fullerene is administered

“…До-слідження токсичності С 60 фулеренів показали, що за низьких концентрацій вони не виявляють токсич-них ефектів щодо нормальних клітин, є неімуноген-ними та неалергенними, здатні регулювати вільно-радикальні процеси у клітинах і тканинах організму, зокрема нейтралізувати надлишок вільних ради-калів [7,8].…”