Study of surface enhanced Raman scattering (SERS) within hollow core photonic crystal fiber

Tiwari, Vidhu S.; Khetani, Altaf; Naji, Majid; Anis, Hanan

doi:10.1109/icsens.2009.5398238

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…Owing to the inherent spectral shift associated with HC‐PCF once it is filled with the liquid‐analyte and related narrow spectral bandwidth, one should take into consideration that both the excitation and Stokes shifted Raman signals should be within this shifted transmission band. Spectral shift associated with HC‐PCF was clearly observed as reported by Tiwari et al . Here, commercial fiber with transmission window centered at 1550 nm was shifted to ~810 nm when it was filled with an aqueous solution of AgNP and Rh6G mixture.…”

Section: Conclusion and Future Perspectivessupporting

confidence: 75%

“…It was first used to evaluate the effectiveness of an HC‐PCF (modified into a liquid‐core HC‐PCF by sealing the cladding holes before filling liquid in to the core by capillary action) as a SERS platform when mixed with silver nanoparticles (AgNPs), resulting in an improved signal enhancement by a factor of 100 compared with a sample dried on a planar substrate using a 785 nm laser . Tiwari et al compared the Raman signal from different lengths of HC‐PCF (HC‐1550; Thorlabs) that had been non‐selectively filled with analyte. Rh6G solution was mixed with AgNPs in a 1:1 volume ratio before filling HC‐PCFs with six different lengths by capillary action.…”

Section: Applications Of Raman/sers‐active Pcf Probesmentioning

confidence: 99%

“…Such a configuration enables biosensing at extremely low sample volume (nL) and provides very high sensitivity of the order of pM for the detection of biomarkers . SERS‐active PCF probes offer at least 2 to 3 orders higher sensitivity than conventional sensing on planar substrates, which is highly significant in the context of biosensing .…”

Section: Introductionmentioning

confidence: 99%

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Surface‐enhanced Raman scattering‐active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity

Dinish

Beffara

Humbert

et al. 2019

Journal of Biophotonics

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The tremendous enhancement factors that surface-enhanced Raman scattering (SERS) possesses coupled with the flexibility of photonic crystal fibers (PCFs) pave the way to a new generation of ultrasensitive biosensors. Thanks to the unique structure of PCFs, which allows direct incorporation of an analyte into the axially aligned air channels, interaction between the analyte and excitation light could be increased many folds leading to flexible, reliable and sensitive probes that can be used in preclinical or clinical biosensing. SERS-active PCF probes provide unique opportunity to develop an opto-fluidic liquid biopsy needle sensor that enables one-step integrated sample collection and testing for disease diagnosis.Specificity being a key parameter to biosensors, the PCF inside the biopsy needle could be functionalized with targeting moieties to detect specific biomarkers. In this review article, we present some of the most promising recent biosensors based on PCFs including hollow-core PCFs, suspended-core PCFs and side-channel PCFs. We provide a wide range of applications of such platform using Raman spectroscopy, label free SERS or labeled SERS detection and analyze some of the main challenges to be addressed for translating it to a clinically viable next generation sensitive biopsy needle sensing probe. K E Y W O R D S biosensor, liquid biopsy, photonic crystal fiber, Raman spectroscopy, surface-enhanced Raman spectroscopy

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Section: Conclusion and Future Perspectivessupporting

confidence: 75%

Section: Applications Of Raman/sers‐active Pcf Probesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface‐enhanced Raman scattering‐active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity

Dinish

Beffara

Humbert

et al. 2019

Journal of Biophotonics

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“…It has been shown that the enhancement technique in all LCW platforms is mainly based on its use as a waveguide to confine both the sample and the optical field over a long distance to obtain a larger length for light–matter interaction. In this case, the guided wavelength range supported by the fibre is shifted, and the shifted wavelength can be mathematically described as:

λ^{'} = λ_{0} {[\frac{1 - {(\frac{n_{l}}{n_{s}})}^{2}}{1 - {(\frac{n_{a}}{n_{s}})}^{2}}]}^{1 true/ 2}

…”

Section: Theoretical Basis In Fibre‐optic Samplingmentioning

confidence: 99%

“…Optical fibre Raman tips based on SERS are also described in this paper. They share the common feature that increasing the SERS cross section or formation of closely spaced hot nanojunctions results in substantial enhancements …”

Section: Introductionmentioning

confidence: 99%

Review of optical fibre probes for enhanced Raman sensing

Wang

Zeng

et al. 2017

J Raman Spectroscopy

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Raman scattering is a photon‐molecular interaction based on the kinetic modes of an analyte. It offers unique fingerprint‐type signals that allow molecular identification. A serious challenge frequently encountered in Raman measurements arises from the requirements of fast, real‐time remote sensing, fluorescence suppression, ultra‐micro concentration detection, small sample volumes and label‐free biological specimens. This review focuses on fibre‐optic probes for Raman spectroscopy, especially for enhanced sampling applications. It aims at providing an overview over contemporary technology and recent excellent researches, and helps identifying future developments necessary to bring the emerging technology to instrument manufacturers and end users. After a short introduction to surface‐enhanced Raman scattering technology, professional algorithms for design optimization of the fibre Raman probe will be discussed and general design considerations presented. Subsequently, various common geometries employed for enhanced Raman sampling are enumerated based on the types of waveguide fibres: multi‐fibre optodes, long‐pathlength capillary, microstructured photonic crystal fibre and other waveguide arrangements. Additionally, the relevant detection parameters are reviewed, such as target analyte, limit of detection, waveguide media and detection principle. The review also includes a brief summary of the advantages and limitations of various fibre Raman probes. Finally, the future work is discussed which will promote the reliability and the applicability of fibre enhanced Raman sensors. Copyright © 2017 John Wiley & Sons, Ltd.

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Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid

Beffara

Perumal

Mahyuddin

et al. 2019

Journal of Biophotonics

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Conventionally Surface‐enhanced Raman spectroscopy (SERS) is realized by adsorbing analytes onto nano‐roughened planar substrate coated with noble metals (silver or gold) or their colloidal nanoparticles (NPs). Nanoscale irregularities in such substrates/NPs could lead to SERS sensors with poor reproducibility and repeatability. Herein, we demonstrate a suspended core photonic crystal fiber (PCF) based SERS sensor with extremely high reproducibility and repeatability in measurement with a relative SD of only 1.5% and 4.6%, respectively, which makes it more reliable than any existing SERS sensor platforms. In addition, our platform could improve the detection sensitivity owing to the increased interaction area between the guided light and the analyte, which is incorporated into the holes that runs along the length of the PCF. Numerical calculation established the significance of the interplay between light coupling efficiency and evanescent field distribution, which could eventually determine the sensitivity and reliability of the developed SERS active‐PCF sensor. As a proof of concept, using this sensor, we demonstrated the detection of haptoglobin, a biomarker for ovarian cancer, contained within the ovarian cyst fluid, which facilitated in differentiating the stages of cancer. We envision that with necessary refinements, this platform could potentially be translated as a next‐generation highly sensitive SERS‐active opto‐fluidic biopsy needle for the detection of biomarkers in body fluids.

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Study of surface enhanced Raman scattering (SERS) within hollow core photonic crystal fiber

Cited by 8 publications

References 9 publications

Surface‐enhanced Raman scattering‐active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity

Surface‐enhanced Raman scattering‐active photonic crystal fiber probe: Towards next generation liquid biopsy sensor with ultra high sensitivity

Review of optical fibre probes for enhanced Raman sensing

Development of highly reliable SERS‐active photonic crystal fiber probe and its application in the detection of ovarian cancer biomarker in cyst fluid

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