Study of the association between long non-coding RNA and clear cell renal cell carcinoma

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant cancers, accounting for about 70% of all RCC cases. The relationship between ccRCC and long non-coding RNA (lncRNA) remains to be further investigated. Methods: Using the PubMed website (https://pubmed.ncbi.nlm.nih.gov), we systematically analyzed current studies focused on lncRNA and ccRCC, covering various aspects including the conceptual features of ccRCC, comprehensive molecular analysis, the biological function of lncRNAs in cancer pathogenesis, their roles as potential prognostic biomarkers, and identification of lncRNAs associated with immune subtypes in ccRCC. Additionally, we summarized models, signatures, and validation for prognostic prediction and treatment, prognostic features, gene identification and landscape, lncRNA regulation, as well as approaches to inhibit the progression and address poor prognosis parameters of ccRCC. Result: Based on the latest research progress of lncRNA in ccRCC, this article reviews its expression, function and related mechanisms, in order to provide reference for the application of lncRNA in the field of cancer. Conclusions: In summary, this review analyzes the current studies focused on lncRNA and ccRCC, highlighting lncRNA's potential as a prognostic biomarker and its role in ccRCC progression and immune subtypes. It aims to provide insights for leveraging lncRNA in cancer research and treatment.