Study of the Association between Serum Ferritin Levels and HbA1c in Patient with Type 2 Diabetes Mellitus in Jordanian Population Sample

Abstract

Background/ aim: The most common endocrine disorder in the world is type 2 DM, affecting 85-90% of all people with diabetes. Several studies have found an association between serum ferritin levels and HbA1c, so the current study was undertaken to examine the association between serum ferritin levels and HbA1c in Jordanian patient’s sample with type 2 DM.
 Method: 120 patients with type 2 DM were enrolled into the current study, and control group consist of 20 healthy individuals, blood samples were collected after 14 h of fasting, 5 ml of fasting sample for FBS and ferritin, 4 ml whole blood taken in EDTA tube for Hb and HbA1c, sample centrifuged and biochemical tests were done in the same day.
 Results: The mean of serum ferittin was significantly higher in patients group (213.87±114.23 ng/ml) than control group (98.34±18.45 ng/ml, P < 0.05). There was a positive association between serum ferritin and HbA1c (P < 0.05). Also there was a significant correlation between serum ferritin and FBS P < 0.05. Among the two groups there was no significant difference regarding demographic features (sex, age and BMI).
 Conclusion: collected data showed that there is a significantly association between ferittin and type 2 DM, it was higher in comparison with healthy group, so it can give an indication of glycemic control in diabetic patients.