Study of the biological function and penetration pathways of the mouse epidermal growth factor ethosomal delivery system

Xing, Xiaojing; Yang, Lang; You, Yi; Zhong, Baiyu; Song, Qiu-He; Deng, Jun; Fei, Hao

doi:10.1111/j.1600-0625.2011.01340.x

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…The¯ndings suggested that follicular penetration had occurred. [15][16][17] However, as the stratum corneum was modi¯ed as animals grew older, a direct comparison between the follicular and the intercellular penetration was not possible. Subsequently, the Center of Experimental and Cutaneous Physiology developed a method permitting the follicular and intercellular penetration to be compared in vivo.…”

Section: Ca®eine Penetration By the Intercellular And Follicular Pathwaymentioning

confidence: 99%

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Hair follicles as a target structure for nanoparticles

Lademann

Knorr

Richter

et al. 2015

J. Innov. Opt. Health Sci.

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For at least two decades, nanoparticles have been investigated for their capability to deliver topically applied substances through the skin barrier. Based on¯ndings that nanoparticles are highly suitable for penetrating the blood-brain barrier, their use for drug delivery through the skin has become a topic of intense research. In spite of the research e®orts by academia and industry, a commercial product permitting the nanoparticle-assisted delivery of topically applied drugs has not yet been developed. However, nanoparticles of approximately 600 nm in diameter have been shown to penetrate e±ciently into the hair follicles, where they can be stored for several days. The successful loading of nanoparticles with drugs and their triggered release inside the hair follicle may present an ideal method for localized drug delivery. Depending on the particle size, such a method would permit targeting speci¯c structures in the hair follicles such as stem cells or immune cells or blood vessels found in the vicinity of the hair follicles.

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Section: Ca®eine Penetration By the Intercellular And Follicular Pathwaymentioning

confidence: 99%

“…[15][16][17] Newborn animals, which had not yet developed any hair follicles, were examined for the penetration of topically applied substances. These experiments were repeated on the same animals once their hair follicles had developed.…”

Section: Ca®eine Penetration By the Intercellular And Follicular Pathwaymentioning

confidence: 99%

Hair follicles as a target structure for nanoparticles

Lademann

Knorr

Richter

et al. 2015

J. Innov. Opt. Health Sci.

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show abstract

“…The transappendageal pathway, which include pathways through hair follicles (follicular pathways) or sweat glands (aqueous pores), has been largely ignored because hair follicles constitute a mere 0.1% of the total skin. However, it is increasingly gaining attention as a promising route that may be a significant contributor for the transport of nanoparticles . Follicles and its connected sebaceous gland comprise what is referred to as the pilosebaceous unit (diameter: 10 μm) .…”

Section: Resultsmentioning

confidence: 99%

Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier

Rao

Chen

Liang

et al. 2014

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The transdermal administration of chemotherapeutic agents is a persistent challenge for tumor treatments. A model anticancer agent, epirubicin (EPI), is attached to functionalized superparamagnetic iron-oxide nanoparticles (SPION). The covalent modification of the SPION results in EPI-SPION, a potential drug delivery vector that uses magnetism for the targeted transdermal chemotherapy of skin tumors. The spherical EPI-SPION composite exhibits excellent magnetic responsiveness with a saturation magnetization intensity of 77.8 emu g(-1) . They feature specific pH-sensitive drug release, targeting the acidic microenvironment typical in common tumor tissues or endosomes/lysosomes. Cellular uptake studies using human keratinocyte HaCaT cells and melanoma WM266 cells demonstrate that SPION have good biocompatibility. After conjugation with EPI, the nanoparticles can inhibit WM266 cell proliferation; its inhibitory effect on tumor proliferation is determined to be dose-dependent. In vitro transdermal studies demonstrate that the EPI-SPION composites can penetrate deep inside the skin driven by an external magnetic field. The magnetic-field-assisted SPION transdermal vector can circumvent the stratum corneum via follicular pathways. The study indicates the potential of a SPION-based vector for feasible transdermal therapy of skin cancer.

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“…Xing et al . used mEGF formulated in ethosomes trying to modulate hair growth phases in mice . Newer peptide and protein delivery strategies for indications in hair therapy range from immunization approaches for tolerance induction in alopecia areata to delivery of PTH‐based compounds in chemotherapy‐induced alopecia , and even non‐invasive delivery of other macromolecules such as superoxide dismutase .…”

Section: ‘Novel’ Deliverymentioning

confidence: 99%

Selective hair therapy: bringing science to the fiction

Vogt

Blume-Peytavi

2014

Experimental Dermatology

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Investigations on carrier-based drug delivery systems for higher selectivity in hair therapy have clearly evolved from dye release and model studies to highly sophisticated approaches, many of which specifically tackle hair indications and the delivery of hair-relevant molecules. Here, we group recent hair diseaseoriented work into efforts towards (i) improved delivery of conventional drugs, (ii) delivery of novel drug classes, for example biomolecules and (iii) targeted delivery on the cellular/molecular level. Considering the solid foundation of experimental work, it does not take a large step outside the current box of thinking to follow the idea of using large carriers (>500 nm, unlikely to penetrate as a whole) for follicular penetration, retention and protection of sensitive compounds. Yet, reports on particles <200 nm being internalized by keratinocytes and dendritic cells at sites of barrier disruption (e.g., hair follicles) combined with recent advances in nanodermatology add interesting new facets to the possibilities carrier technologies could offer, for example, unprecedented levels of selectivity. The authors provide thoughtprovoking ideas on how smart delivery technologies and advances in our molecular understanding of hair pathophysiology could result in a whole new era of hair therapeutics. As the field still largely remains in preclinical investigation, determined efforts towards production of medical grade material and truly translational work are needed to demonstrate surplus value of carrier systems for clinical applications.

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Study of the biological function and penetration pathways of the mouse epidermal growth factor ethosomal delivery system

Cited by 12 publications

References 19 publications

Hair follicles as a target structure for nanoparticles

Hair follicles as a target structure for nanoparticles

Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier

Selective hair therapy: bringing science to the fiction

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