Study of the complexing properties of the dextran carboxymethyl ether with transition metal ions in solutions

Шевченко, Л. И.; Lugovaya, Z.A; Tolmachev, V.N.

doi:10.1016/0032-3950(85)90512-x

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…As a cellular macromolecule, dextran is widely used alone or in combination with metals for medical purposes, often including drug delivery systems 3, 4. In aqueous solutions, dextran interacts with several metal ions and forms solid complex compounds of therapeutic use 5, 6. However, data on the interaction of dextran with lanthanide ions are very limited and mostly reported as patent formulations.…”

Section: Introductionmentioning

confidence: 99%

Dextran–rare earth ion interactions. I. Dynamics in aqueous solutions

Mazi

Zümreoǧlu‐Karan

Güner

2001

J of Applied Polymer Sci

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ABSTRACT:The interaction of light-lanthanoid cations (La 3ϩ , Ce 3ϩ , and Nd 3ϩ ) with dextran in aqueous solutions was studied by viscosimetric, turbidimetric, and conductimetric methods. The effects of the type of the cation and the concentration of the cation on the interaction mechanism were investigated. Viscosity behavior of the solutions was interpreted using the Huggins and Kraemer equations; intrinsic viscosities and the slopes were calculated. The results found from the Huggins and Kraemer approaches accorded well. The order of interaction was determined as La 3ϩ Ͼ Ce 3ϩ Ͼ Nd 3ϩ . In all experimental methods applied, a critical concentration of the Ln 3ϩ ion (Ϸ0.08 mol Ln 3ϩ /L) was noted at which the observed property showed a significant change. Up to this critical concentration, viscosities of the dextran/Ln 3ϩ solutions decreased and after making an outstanding turn at this point increased toward higher concentrations. Turbidimetric and precipitation experiments gave opposite results as expected but the same order for the cation and the same value of critical concentration. The results obtained from the application of a mathematical model to the precipitation data verified the conclusions attained by viscosimetry and conductimetry.

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Section: Introductionmentioning

confidence: 99%

Dextran–rare earth ion interactions. I. Dynamics in aqueous solutions

Mazi

Zümreoǧlu‐Karan

Güner

2001

J of Applied Polymer Sci

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“…The complex of Cu(II) with RLMD obtained by the procedure 2 (Table 1), besides having the highest Cu(II) content (19.85%), also has the highest stability on 3 mol dm −3 HCl hydrolytic effect (12 min). Tolmachev et al [20], in their paper of the influence of medium pH on binding Cu(II) with dextran, point out the possibility of a gradual complexing, i.e. a gradual forming of coordination bonds, with their reforming starting at pH 8.…”

Section: Resultsmentioning

confidence: 99%

The investigations of bioactive copper(II) complexes with reduced low-molar dextran

et al. 2008

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The optimization of the reaction conditions (pH,T,t) to obtain stable copper(II) ion complexes with dextran derivatives were investigated in this paper. A complete synthesis of stable aqueous complexes can be realized with reduced low-molar polysaccharides, at an average molar mass 5000 g mol–1and pH 7.5–8. Fourier-transform IR spectra of polysaccharide dextran and its compounds with copper(II) ion, recorded at room temperature, were analyzed in order to obtain the information about the structure and the conformation of these polymer compounds. The ESR parameters of the spectra indicate the square-planar coordination of Cu(II) ion with four O atoms. Copper(II) complex formation with dextran and its derivatives were analyzed by physicochemical methods. Synthesized complexes of Cu(II) ion with reduced low-molar dextran in comparison with commercial preparations showed the considerably lower acute toxicity (LD501705).

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“…In aqueous solutions dextran interacts with several metal ions and forms solid complex compounds of therapeutic use 3, 4. Paramagnetic particles of dextran–rare earth complexes have also been reported to be promising agents in the treatment of the AIDS virus 5.…”

Section: Introductionmentioning

confidence: 99%

Dextran–rare earth ion interactions. II. Solid‐state characteristics

Zümreoǧlu‐Karan

Mazi

Güner

2001

J of Applied Polymer Sci

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ABSTRACT:The solid-state characteristics of dextran complexes precipitated from aqueous solutions with three different light-lanthanoid cations (La 3ϩ , Ce 3ϩ , and Nd 3ϩ ) were investigated by spectroscopic and thermal methods. Spectroscopic characterization was realized by the comparative interpretation of the FTIR spectra, and the complexes were found to involve both ligating water and dextran through its O(2) and O(3) atoms. Remarkable spectral changes were noted, particularly with La 3ϩ , which parallels the previous solution studies. The order of La 3ϩ Ͼ Ce 3ϩ Ͼ Nd 3ϩ was determined to display the tendency of the Ln 3ϩ ion in favor of dextran throughout the competition between water and dextran. The thermal stabilities of the complexes were examined by thermogravimetry (TG), differential TG, and DSC methods. The decomposition steps and temperatures were assigned with respect to the lanthanoid ions used. The TG and DSC results indicated that the complexes are less stable thermally than dextran itself with increasing thermal stabilities in the order of La 3ϩ Ͻ Ce 3ϩ Ͻ Nd 3ϩ in their anhydrous states.

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Study of the complexing properties of the dextran carboxymethyl ether with transition metal ions in solutions

Cited by 5 publications

References 3 publications

Dextran–rare earth ion interactions. I. Dynamics in aqueous solutions

Dextran–rare earth ion interactions. I. Dynamics in aqueous solutions

The investigations of bioactive copper(II) complexes with reduced low-molar dextran

Dextran–rare earth ion interactions. II. Solid‐state characteristics

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