Study of the Hemodynamics Effects of an Isolated Systolic Hypertension (ISH) Condition on Cerebral Aneurysms Models, Using FSI Simulations

Barahona, José; Valencia, Álvaro; Torres, María Josefina

doi:10.3390/app11062595

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Subsequent FSI simulations of the acquired geometry compared the results obtained with a uniform thickness configuration (0.3 mm) and with the specific thickness distribution measured in micro-CT, revealing peak local stress variations of around 50%. A few other research teams proposed similar studies [ 14 , 18 , 19 ] but always investigated different cohorts of aneurysm cases composed of a few specimens only. This, along with different modelling assumptions, undermines comparisons between them, thereby limiting the reproducibility of the reported results.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Intracranial Aneurysm Haemodynamics Altered by Wall Movement

Goetz,

Jeken-Rico,

Chau

et al. 2024

Bioengineering

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Computational fluid dynamics is intensively used to deepen our understanding of aneurysm growth and rupture in an attempt to support physicians during therapy planning. Numerous studies assumed fully rigid vessel walls in their simulations, whose sole haemodynamics may fail to provide a satisfactory criterion for rupture risk assessment. Moreover, direct in vivo observations of intracranial aneurysm pulsation were recently reported, encouraging the development of fluid–structure interaction for their modelling and for new assessments. In this work, we describe a new fluid–structure interaction functional setting for the careful evaluation of different aneurysm shapes. The configurations consist of three real aneurysm domes positioned on a toroidal channel. All geometric features, employed meshes, flow quantities, comparisons with the rigid wall model and corresponding plots are provided for the sake of reproducibility. The results emphasise the alteration of flow patterns and haemodynamic descriptors when wall deformations were taken into account compared with a standard rigid wall approach, thereby underlining the impact of fluid–structure interaction modelling.

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Section: Introductionmentioning

confidence: 99%

Analysis of Intracranial Aneurysm Haemodynamics Altered by Wall Movement

Goetz,

Jeken-Rico,

Chau

et al. 2024

Bioengineering

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“…The induced stress on the aneurysm wall was observed to increase rapidly with increasing aneurysm diameter and blood pressure, predicting the risk of rupture for aneurysms of known size ( Yadav et al, 2022 ). A fluid-structure interaction (FSI) simulation study of a CA model conditioned by isolated systolic hypertension to simulate the maximum risk factors for CAs in humans by setting each parameter of hemodynamics ( Barahona et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The biomechanical effects of different membrane layer structures and material constitutive modeling on patient-specific cerebral aneurysms

Fan,

Zhang,

Zheng

et al. 2024

Front. Bioeng. Biotechnol.

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The prevention, control and treatment of cerebral aneurysm (CA) has become a common concern of human society, and by simulating the biomechanical environment of CA using finite element analysis (FEA), the risk of aneurysm rupture can be predicted and evaluated. The target models of the current study are mainly idealized single-layer linear elastic cerebral aneurysm models, which do not take into account the effects of the vessel wall structure, material constitution, and structure of the real CA model on the mechanical parameters. This study proposes a reconstruction method for patient-specific trilaminar CA structural modeling. Using two-way fluid-structure interaction (FSI), we comparatively analyzed the effects of the differences between linear and hyperelastic materials and three-layer and single-layer membrane structures on various hemodynamic parameters of the CA model. It was found that the numerical effects of the different CA membrane structures and material constitution on the stresses and wall deformations were obvious, but does not affect the change in its distribution pattern and had little effect on the blood flow patterns. For the same material constitution, the stress of the three-layer membrane structure were more than 10.1% larger than that of the single-layer membrane structure. For the same membrane structure, the stress of the hyperelastic material were more than 5.4% larger than that of the linear elastic material, and the displacement of the hyperelastic material is smaller than that of the linear elastic material by about 20%. And the maximum value of stress occurred in the media, and the maximum displacement occurred in the intima. In addition, the upper region of the tumor is the maximum rupture risk region for CA, and the neck of the tumor and the bifurcation of the artery are also the sub-rupture risk regions to focus on. This study can provide data support for the selection of model materials for CA simulation and analysis, as well as a theoretical basis for clinical studies and subsequent research methods.

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