Study of the Possible Antihypertensive and Hypolipidemic Effects of an Herbal Mixture on L-Name-Induced Hypertensive Rats

Abstract

Objective: Hypertension is a chronic medical condition. Diet can improve blood pressure control and decrease the risk of health complication.Methods: In this study, four plants: Roselle, Marjoram, Chamomile, and Doum were extracted by water. Equal portions of them were mixed. Lethaldose 50% of the mixture was assayed; the dose which did not cause any mortality was 266.94 mg/100 g body weight. Animals were classified into fivegroups: Negative control group, positive control group where hypertension was induced by L-name, two groups treated with two doses of the mixture,and a group treated with prazosin as a standard treatment. Treatment of hypertensive rats continued for 4 successive weeks.Results: Treatment with the mixture showed a significant reduction in blood pressure of hypertensive rats, as well as serum cholesterol, low-densitylipoprotein-cholesterol, and urea levels when compared to positive control group.Conclusion: The results obtained suggest that the aqueous extract is efficient as an antihypertensive and hypolipidemic agent.Keywords: Rats, Aqueous extract, Hypertension, Hyperlipidemia, L-name.

A pharmacological and toxicological biochemical study of cardiovascular regulatory effects of hibiscus, corn silk, marjoram, and chamomile

“…In fact, the active ingredients in many medicinal plants are represented by bioactive substances such as flavonoids. Flavonoids have been tested for their potential therapeutic effects in various diseases [ 3 , [27] , [28] , [29] , [30] , [31] , [32] ].…”

“…Females are liable to develop hypertension after menstrual cessation due to the absence of the cardio-protective effects of female sex hormones [ 1 , 2 ]. Since the severe elevation of blood pressure may occur without any signs or complaints from patients and may dramatically worsen, ending in mortality, therefore it was termed “The Silent Killer” [ 3 ].…”

“…They include inhibitors of angiotensin-converting enzyme (ACEI), antagonists of angiotensin-receptor (ARBs), thiazides and thiazide-like diuretics, calcium channel blockers, alpha-blockers, and central adrenergic inhibitors. The occurrence of adverse effects of antihypertensive agents, such as cough, fatigue, sedation, orthostatic hypotension, and occurrence of depression with the intake of higher doses [ 3 ], was the motive to search for natural alternative supplementary products to help in the reduction of the side effects.…”

“…Lastly, Chamomile's flavonoids and other bioactive compounds contribute to its blood pressure-lowering results by reducing cholesterol levels and atherosclerosis development. These herbal components, when combined in the current study's mixture, have the potential to exert synergistic antihypertensive effects, providing a promising natural alternative for managing elevated blood pressure [ 3 , [5] , [6] , [7] ]. There is a strong relation between protection against the occurrence of cardiovascular diseases and consumption of flavonoids in diet.…”

An overview on medicinal plants used for combating coronavirus: Current potentials and challenges

“…In addition, the flavonoids of Caesalpinia minaxare and Viscum album exhibit promising inhibition to CoVs. Flavonoid is considered as one of the most common phytocompounds in plants, being biologically active, flavonoids have diverse effects on health [ [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] ]. Khaerunnisa et al [ 84 ] examined natural metabolites that can inhibit 3CLpro, highlighting the important results of quercetin, kaempferol, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucosin, catechins, curcumin, and epigallocatechin.…”