The aim of this study was to compare the shaping ability of a recently introduced instrument (Revo-S) in comparison with the four current instruments (HeroShaper, Mtwo, ProTaper, RaCe) in simulated root canals. Material and methods: Nickel-Titanium systems (n=15 resin in each case) were used to prepare 34-35° curved and S-shaped simulated root canals in clear resin blocks. The width of resin removal was measured by comparing the pre-and postoperative images under a stereomicroscope. The amount and direction of transportation, the centering ability and the total amount of resin removal were determined. Canal aberration incidence, preparation time, and instrument deformation were also recorded. Results: In both canal types, the RaCe group prepared canals more rapidly (P < 0.05) and created no canal aberrations.The ProTaper Universal group was significantly slower than other groups (P < 0.05) for both canal types. The tapered canal form was obtained in the Mtwo, ProTaper Universal; and RaCe groups in 34-35° curved canals; and only the RaCe group in S-shaped canals. Some deformations but no instrument fractures were observed for HeroShaper, Mtwo, and Revo-S groups. Conclusion: RaCe rotary Nickel-Titanium instruments, probably do to their triangular cross-sectional shape with alternating cutting edges and sequence encompassing a high number of instruments, exhibited a better centrally shaping and fewer canal aberrations.