Study of the Protective Effects of Flaxseed Oil on Ethanol Induced Gastric Mucosal Lesions in Non Ovariectomized and Ovariectomized Rats

Ibrahim, Bassant M. M.; Salama, Abeer; Abdallah, Heba M. I.; Awdan, Sally A. El; Shaffie, Nermeen

doi:10.3923/ijp.2016.329.339

Cited by 16 publications

(17 citation statements)

References 15 publications

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“…While the antiulcerogenic activity of linseed oil is due to its cyto-protective effect [7] and its high content of essential fatty acids (linoleic acid n α-linolenic acid), which regulate prostaglandins synthesis [37]. These results were in accordance with Ibrahim et al [38] who reported that oral administration of linseed oil has a protective effect against gastric ulcer in rats.…”

Section: Discussionsupporting

confidence: 80%

Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Ibrahim

Telep

Hemed

2019

Zagazig Veterinary Journal

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Gastric ulcer is a standout amongst the most significant gastrointestinal disorders affecting human worldwide. An extraordinary interest should be given to find natural medications to treat this disease. Plant extracts are more favored because of their wide safety margins and less or no adverse health impacts. The present study was conducted to assess the antiulcer activities of hydroethanolic extract of moringa leaves (00m K n linseed oil (0.3mL/ Kg BW) on piroxicam (30 m K) induced gastric ulcers in Wister albino rats. Forty five adult male albino rats were allocated into five equal (9 each) groups designated as negative control, piroxicam, ranitidine, moringa and linseed oil groups. The results revealed that administration of piroxicam in a single oral dose induced gastric ulcers in rats, decrease in body weights (187.50±10.51g) and increase in gastric juice (1.64±0.24mL) with altered hematological, biochemical and histological findings. Meanwhile, oral administration of ranitidine, Moringa oleifera and linseed oil ameliorated the ulcerogenic effect of piroxicam with curative ratios of 100, 97.5 and 100%, respectively. From the previous findings we concluded that hydroethanolic extract of moringa leaves and linseed oil were effective treatments of piroxicam induced gastric ulcer in rats. Antiulcerogenic effect of moringa and linseed oil may be attributed to their antiinflammatory and antioxidant properties.

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Section: Discussionsupporting

confidence: 80%

Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Ibrahim

Telep

Hemed

2019

Zagazig Veterinary Journal

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“…In the current study, gastric ulcer was induced by ethanol as it has a rapid infiltration rate to the gastric mucosa impairing gastric self-protective mechanism. It also has several pathological characteristic properties of the human peptic ulcer [25,26] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore the defect of the gastric mucosal barriers might cause bacterial invasion. These bacteria were also chemotactic factor for mononuclear cells leading to gastritis and mucosal ulceration [26,31] . Moreover, the aforementioned cytokines had a vulnerable role in stimulation of fibroblasts and transforming them into myofibroblasts, that initiate fibrosis [25,29,32] .…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism of action of ethanol induced gastric ulcer mediated through multifactorial process as various cytokines release, lipid peroxidation, generation of reactive oxygen species, oxidative damage, modification in permeability and depolarization of the mitochondrial membrane before cell death [7,26,37] . Previous related studies [1] revealed that the strong antioxidant action of the pomegranate peel extract had adequate potential as an antiulcer mediator.…”

Section: Discussionmentioning

confidence: 99%

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Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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Introduction: Gastric ulcers are the most prevalent gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects. Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising therapeutic potential for curing human diseases. Aim of the work: To evaluate the effect of pomegranate and BMSCs on experimentally induced gastric ulcer in adult male rats. Materials and Methods: Sixty adult male rats were divided into four groups. Group I kept as the control group. Group II (Gastric ulcer), rats received 100% ethanol orally by gastric tube. Group (III) subdivided into 3 subgroups. Subgroup IIIa included rats with gastric ulcer that treated with pomegranate only. Subgroup IIIb, rats with gastric ulcer treated with BMSCs alone. Subgroup IIIc; gastric ulcer rats treated with a combination of pomegranate and BMSCs. Group IV included the untreated gastric ulcer rats. Fundus of stomach specimens were prepared and examined using histological and immunohistochemical techniques. Results: Groups II and IV showed various changes as deep erosion, marked damage of most of the cells. The presence of the inflammatory cells in gastric mucosa were supported by a significant increase of tumor necrosis factor α (TNF-α) expression and collagen fibers depositions (P<0.01). A significant decrease of Periodic Acid Schiff (PAS) positive reaction and vascular endothelial growth factor (VEGF) expression was observed (P<0.01). Subgroup IIIa showed attenuation of some histological changes, while subgroups IIIb and IIIc revealed more improvement of the histological and immunohistochemical changes described before. Conclusion: BMSCs can ameliorate experimentally-induced gastric injury in rats and protect the gastric tissue. Addition of pomegranate to BMSCs can lead to better results.

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“…Nowadays, gastric ulcer is measured as new plague of the 21 st century [1] . It is the common gastrointestinal (GIT) and global disorder that occurs mainly due to many destructive factors of the mucosal barrier and/or imbalance between the destructive and defensive ones [2] .…”

Section: Introductionmentioning

confidence: 99%

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Mohamed

Ahmed

Shalaby

et al. 2019

Journal of Medical Histology

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Background: Estrogen is a principal female sex hormone that originally characterized by its importance in sexual growth and reproduction. Nevertheless, emergent evidence proposes clinical relationship between estrogen/ estrogen receptors and gastric diseases. This association is definitely under several investigated topics. Aim: The current study designed to explore exogenous estrogen effect on indomethacin-induced gastric ulcers in postmenopausal female rats. Matrial and methods: Twenty-four female rats (200 ± 20 gram BW) were allocated randomly into four groups; control, ulcer-induced, ranitidine-treated and (ranitidine&estradiol velerate) combined-treated group. Animal in all group except control subjected to ovariectomy to assimilate menopausal condition. At end of the experiment, the stomach fundus examined macroscopically to assess the ulcer severity and ulcer score in different groups. Histopatholgical and biochemical evaluation also were performed and all results were statistically analyzed. Results: Indomethacin-induced gastric ulcer in ovariectomized rats showed destroyed fundic mucosa and mucus layer, increase oxidative stress markers, inflammatory mediators and myeloperoxidase. Treatment with ranitidine attenuated the histological and biochemical changes but within limits. Better improvement was accomplished when ranitidine combined with estrogen. Conclusion: The postmenopausal women should be supplemented with estrogen not only to control menopausal symptoms but also to protect and maintain gastric mucosal integrity.

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Study of the Protective Effects of Flaxseed Oil on Ethanol Induced Gastric Mucosal Lesions in Non Ovariectomized and Ovariectomized Rats

Cited by 16 publications

References 15 publications

Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

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