Study of the spatial distribution of the absorbed dose in blood volumes irradiated using a teletherapy unit

Góes, Evamberto Garcia de; Nicolucci, Patrícia; Nali, I.C.; Pelá, Carlos Alberto; Bruço, J.L.; Borges, J.C.; Covas, Dimas Tadeu

doi:10.1016/j.radphyschem.2010.01.015

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…However, ANVISA Resolution RDC 34, of June 14 th 2004, establishes that "the irradiation of blood components should preferably be done in a cell irradiator suitable for irradiating blood and components" [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Quality control in blood irradiation

et al. 2023

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Irradiation is a technique used in hemotherapy to functionally inactivateviable lymphocytes, in cellular blood components, to reduce the risk of Transfusion-associated Graft-versus-Host Disease (AT-GVHD), is rare but letal. One way to avoid it is to irradiate blood componentes in situations such as: intrauterine transfusion, newborns, patients receiving immunosuppressive therapy in bone marrow transplantation. Thus, it is extremely important that blood component is irradiated and, above all, ensure that the minimum dose is 25 Gy.The blood policy in Brazil is implemented through laws and normative decrees, giving rise to a legal system that underpins the actions of hemotherapy services. In order to correct verify absorbed doses and the quality assurance process as well as the safety for the irradiator operators we describe in this paper a several of physical measurements that is mandatory to support a physicist to evaluate the quality assurance during and after the irradiation process. The results obtained from this physical measurements provided a guarantee of proper radiation dose used in hemotherapy as well as methods and procedures applied to protect the patient, employees and general public due to procedure of blood irradiation accordling the Technical Regulation of Hemotherapy Procedures of the National Health Surveillance Agency (ANVISA) and safety regulations by National Nuclear Energy Commission (CNEN).

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Section: Introductionmentioning

confidence: 99%

Quality control in blood irradiation

et al. 2023

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“…Neste caso, um tempo de armazenamento dos produtos irradiados, de pelo menos quinze horas, pode ser necessário antes da transfusão. Ademais, uma vez que os serviços de teleterapia não dispõem de horários ociosos em sua programação,é necessário minimizar Vários sistemas dosimétricos já foram propostos e/ou empregados para o controle de qualidade no processo de irradiação de sangue: TLD [4,113], o próprio Fricke em forma de solução aquosa [114], dosímetros colorimétricos [115] e filme radiocrômico [8]. Dosímetros de estado sólido também já foram sugeridos e incluem os feitos de polimetacrilato (do tipo red perspex ) [4], de alanina [10,116], os do tipo MOSFET [5] e os diodos [117].…”

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Caracterização e adaptação do dosímetro Fricke para dosimetria em irradiação de sangue

Lama¹,

Sacchini²

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The Transfusion Associated Graft Versus Host Disease (TA-GVHD) is a rare transfusion reaction, however fatal, which develops due to the presence of donor T lymphocytes in the donated blood and that can be avoided by the irradiation of the donated blood blood and blood components prior to transfusion. Thus, the associated quality control of blood irradiation is necessary to guarantee the quality of the transfused product. In this work it is proposed the characterization and adaptation of the response of a Fricke dosimeter to be used for dosimetry of blood irradiation, more especiafically the Fricke Xylenol Gel (FXG). This is a radiochromic chemical dosimeter, which presents advantages to be tissue equivalent and allows the spatial absorbed dose inference. In this manner, in a way to possibilitate the absorbed dose inference in the full interval used for the prevention of the TA-GVHD (25 to 50 Gy) the FXG was characterized and adapted for dosimetry applications involving blood and blood components irradiation. The results with the new dosimeter showed adequability for the necessary absorbed doses, with satisfactory sensibility and time fading for routine applications. Furthermore, according to the methodology proposed in this work, it was possible to determine the spatial absorbed dose distributions with the new dosimeter in an fast and simple way, showing that this dosimeter presents convenient characteristics for dosimetry quality control of irradiated the blood and blood components.

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Avaliação de dose nos sistemas de irradiação de bolsas de sangue para esterilização

Associada¹,

Oliveira²

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Study of the spatial distribution of the absorbed dose in blood volumes irradiated using a teletherapy unit

Cited by 3 publications

References 15 publications

Quality control in blood irradiation

Quality control in blood irradiation

Caracterização e adaptação do dosímetro Fricke para dosimetria em irradiação de sangue

Avaliação de dose nos sistemas de irradiação de bolsas de sangue para esterilização

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