Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles

Matsuoka, K.; Nakazawa, Tomomi; Nakamura, Ai; Honda, Chikako; Endo, Kazutoyo; Tsukada, Masamichi

doi:10.1016/j.chemphyslip.2008.05.002

Cited by 50 publications

(39 citation statements)

References 21 publications

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“…A number of studies have examined the thermodynamics of sterol solubilities in micelles and have demonstrated competition between cholesterol and other sterols for incorporation into micelles [4,5,7,24,25]. Although we also observed this competition, our results contrast markedly with those from several other studies.…”

Section: Discussioncontrasting

confidence: 84%

Phytosterol Ester Constituents Affect Micellar Cholesterol Solubility in Model Bile

Brown

Hang

Dussault

et al. 2010

Lipids

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Plant sterols and stanols (phytosterols) and their esters are nutraceuticals that lower LDL cholesterol, but the mechanisms of action are not fully understood. We hypothesized that intact esters and simulated hydrolysis products of esters (phytosterols and fatty acids in equal ratios) would differentially affect the solubility of cholesterol in model bile mixed micelles in vitro. Sodium salts of glycine- and taurine-conjugated bile acids were sonicated with phosphatidylcholine and either sterol esters or combinations of sterols and fatty acids to determine the amount of cholesterol solubilized into micelles. Intact sterol esters did not solubilize into micelles, nor did they alter cholesterol solubility. However, free sterols and fatty acids altered cholesterol solubility independently (no interaction effect). Equal contents of cholesterol and either campesterol, stigmasterol, sitosterol, or stigmastanol (sitostanol) decreased cholesterol solubility in micelles by approximately 50% compared to no phytosterol present, with stigmasterol performing slightly better than sitosterol. Phytosterols competed with cholesterol in a dose-dependent manner, demonstrating a 1:1 M substitution of phytosterol for cholesterol in micelle preparations. Unsaturated fatty acids increased the micelle solubility of sterols as compared with saturated or no fatty acids. No differences were detected in the size of the model micelles. Together, these data indicate that stigmasterol combined with saturated fatty acids may be more effective at lowering cholesterol micelle solubility in vivo.

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Section: Discussioncontrasting

confidence: 84%

Phytosterol Ester Constituents Affect Micellar Cholesterol Solubility in Model Bile

Brown

Hang

Dussault

et al. 2010

Lipids

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“…Similar aqueous solubilities of sterol/stanol have also been reported by others 7,14,15,20,21 . Therefore, the aqueous solubility of fucosterol at 308.2 K was measured using the method reported by Matsuoka et al 7 .…”

Section: Aqueous Solubility Of Fucosterolsupporting

confidence: 69%

Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System

et al. 2015

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“…According to Wu et al (2006), stigmasterols are one of the major sterol in plant plasma membrane and it controls the plasma cholesterol level in vertebrate. b-sitosterol inhibits cholesterol absorption in the intestine (Matsuoka et al 2008). Therefore, it can be assumed that stigmasterols play an important role in the life cycles of both the parasites i.e.…”

Section: Discussionmentioning

confidence: 99%

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

Mondal¹,

Kundu

Misra³

2016

J Parasit Dis

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Lipid synthesis is an important process in most organisms as well as in helminths. The present observation shows the variation of lipid and fatty acid uptake among cestode, Raillietina (Fuhrmannetta) echinobothrida; nematode, Ascaridia galli and their host, Gallus domesticus, the common country fowl. Total lipid (TL), neutral lipid (NL), glycolipid (GL), phospholipid (PL) and their fatty acid of cestode, nematode and liver and intestinal fluid of the host were analyzed by thin layer chromatography and gas liquid chromatography respectively. The result shows that liver take more TL, PL and GL except NL. Utilization of lipid from intestinal fluid when compare between the parasites, it is found that TL and PL content of cestode are higher than nematode, whereas, nematode absorbs more NL and GL than cestode. The percent of cholesterol is more in cestode than nematode. Palmitic, stearic, oleic and linoleic are the predominant fatty acids among all the samples. The present study reveals that the cestode having large surface area is more opportunistic in the resource utilization over the nematode as well as the host.

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Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles

Cited by 50 publications

References 21 publications

Phytosterol Ester Constituents Affect Micellar Cholesterol Solubility in Model Bile

Phytosterol Ester Constituents Affect Micellar Cholesterol Solubility in Model Bile

Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System

Variation in lipid and fatty acid uptake among nematode and cestode parasites and their host, domestic fowl: host–parasite interaction

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