Study of thyroid profile in seropositive HIV adults patients on HAART regimen

Verma, Rajendra Kumar; Giri, Richa; Gupta, Chirag; Srivastava, Vartika

doi:10.18203/2349-3933.ijam20173238

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…This study shows increased level of TSH and fT3 which is significantly high in group 1 subjects than the group 2 and 3 subjects. The increased level of TSH and fT3 is also observed in Verma R.K et al, [16] and [17] studies in which thyroid dysfunction was significantly more frequent in the HAART group 1 than in group 2. Also T4 is significantly higher on group 2 subjects than the group 1 and 3 subjects.…”

Section: Discussionsupporting

confidence: 69%

Evaluation of Thyroid Function of HIV Patients in Umunze, Anambra State, Nigeria

Ukodei,

Nnamah,

Onuegbu

et al. 2023

AJMAH

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Background: Abnormal thyroid function tests have been detected at various phases in people living with Human immunodeficiency virus (HIV) and the effect of highly active antiretroviral therapy (HAART) not well understood. However, there is insufficient study among Nigerians living with HIV. Objective: This study is aimed to determine thyroid hormones in HIV positive individuals compared with HIV negative individuals in Umunze, Anambra State, Nigeria. Materials and Methods: This cross-sectional study was carried out over a period of six months among 95 HIV positive and 30 HIV negative individuals attending USAID/FHI clinic of Immaculate Heart Hospital in Umunze, Nigeria. The subjects were divided into three groups on the basis of HAART (those on HAART [48] – GROUP 1, HAART naïve [47] – GROUP 2 and Control [30] – GROUP 3). The subjects were interviewed, examined and blood sample collected for determination of thyroid function parameters which include thyroid stimulating hormone (TSH), free triiodothyronine (fT3), triiodothyronine (T3), free thyroxine (fT4), and thyroxine (T4). Results: Among the 125 subjects recruited for the study 67.2% were females and 32.8% males. The mean levels of TSH and fT3 was found to be higher in group 1 subjects than in group 2 and the group 3 subjects. The mean level of T4 was significantly higher in group 2 subjects than group 1 and the group 3 subjects. The level of T3 was significantly lower in control subjects in comparison to both HAART and non-HAART subjects. Primary hypothyroidism is the commonest pattern of thyroid dysfunction among the HIV positive patients followed by isolated low fT4. Conclusion: Serum levels of thyroid hormones as shown in this study may be used as baseline periodic markers during antiretroviral therapy while people living with HIV may benefit from supplementation if appropriate. There is also need for a larger study to identify the risk factors for progression to overt thyroid disease in HIV infected subjects with thyroid autoimmunity.

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Section: Discussionsupporting

confidence: 69%

Evaluation of Thyroid Function of HIV Patients in Umunze, Anambra State, Nigeria

Ukodei,

Nnamah,

Onuegbu

et al. 2023

AJMAH

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“…12 There are many studies showing correlation between HIV infection and its associated conditions like stage of infection, CD4 count, OIs, HAART and thyroiddysfunction. [13][14][15][16][17] However, these correlations are unclear.…”

Section: Discussionmentioning

confidence: 99%

Thyroid dysfunction in human immuno-deficiency virus infected patients: a non-randomized, cross-sectional, single-center study

Mujawar

Byakod²,

P.³

et al. 2023

Int J Res Med Sci

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Background: Increasing prevalence of thyroid dysfunction has been reported in human immuno-deficiency virus (HIV)-infected patients. However, there is insufficient evidence to recommend routine thyroid screening of asymptomatic individuals. Hence, this study was undertaken in an attempt to resolve these issues. Objectives of this non-randomized, cross-sectional, single-center study was to study thyroid function in HIV positive patients at various stages of disease. Methods: This single-center study was carried out at Al-Ameen Medical College Hospital and Government District Hospital Bijapur, Karnataka, India from December 2020 to December 2022. The final selected study population included newly diagnosed adult and adolescent (17-60 years) HIV+ patients was composed of 100 participants of either gender. Patients were interviewed and enrolled in the study after examining in detail according to the proforma and then by taking their written consent and explaining the purpose of the study. The thyroid hormone assays (S. TSH, FT3 and FT4) were done by chemiluminescence immuno assay (CLIA) using ADVIA Centaur-equipment. Results: Overall mean age was 36 years (range in years: 17–66 years) and 66 patients (66%) were males. Male: female ratio of 1.94:1 was recorded. In the 50 patients having acquired immuno-deficiency virus (AIDS), FT3 levels ranged from 0.230 to 4.0 picogram/ml with a mean of 2.131+0.9826 picogram/ml. In 50 patients having AIDS, the FT4 levels ranged from 0.30 to 1.90 nanogram/dI with a mean 1.179±0.4484 nanogram/dl. Conclusions: All forms of thyroid dysfunction were observed.

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Evaluation of Thyroid and Lipid Profile of Hiv Patients Seen in a Faith-Based Health Facility in Anambra State, Nigeria

FU,

NK,

et al. 2023

Ann Clin Endocrinol Metabol

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Background: Human Immunodeficiency Virus (HIV) and thyroid function have been described. Prevalence pattern and atherogenic status significantly differ from HIV-negative control in several studies. Unfortunately, few studies have determined the prevalence of thyroid function and lipids among Nigerians living with HIV. Objective: This study is to evaluate thyroid hormones and lipid profiles in HIV-positive subjects attending a faith-based health facility in Anambra State Nigeria. Materials and methods: The serum concentration of Thyroid Stimulating Hormone (TSH), free Triiodothyronine (fT3), triiodothyronine (T3), free Thyroxine (fT4), Thyroxine (T4), Total Cholesterol [TC], Triglyceride [TG], High-Density Lipoprotein [HDL], Low-Density Lipoprotein [LDL] and Very Low-Density Lipoprotein [VLDL] was determined in 95 HIV positive subjects which include 48 patients who were on HAART- group 1 and 47 not on HAART- group 2; and compared to 30 HIV negative controls – group 3. Results: The level of TSH and fT3 was significantly (p < 0.05) higher in group 1 participants than in group 2 and the group 3 participants. The level of T4 was significantly higher in group 2 than in group 1 and group 3 participants. The level of T3 was significantly lower in Control participants in comparison to both HAART and non-HAART participants. The prevalence of fT4 dysfunction across the groups was significantly different from each other. The total mean of Cholesterol (163.5 ± 22.7), Triglyceride (163.5 ± 22.7), and Very Low-Density Lipoprotein (14.2 ± 2.4) of the HIV-positive participants were significantly (p < 0.05) lower than that of the HIV negative participants. Conclusion: The results obtained from this study indicate that serum levels of thyroid hormones may be used as baseline periodic markers during antiretroviral therapy and many people living with HIV may benefit from supplementation if appropriate.

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Study of thyroid profile in seropositive HIV adults patients on HAART regimen

Cited by 3 publications

References 9 publications

Evaluation of Thyroid Function of HIV Patients in Umunze, Anambra State, Nigeria

Evaluation of Thyroid Function of HIV Patients in Umunze, Anambra State, Nigeria

Thyroid dysfunction in human immuno-deficiency virus infected patients: a non-randomized, cross-sectional, single-center study

Evaluation of Thyroid and Lipid Profile of Hiv Patients Seen in a Faith-Based Health Facility in Anambra State, Nigeria

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