Study of trace elements in mixed saliva of caries free and caries active children

Zahir, Shabnam; Sarkar, Subir

doi:10.4103/0970-4388.22832

Cited by 23 publications

(3 citation statements)

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“…For caries, previous works in saliva have mainly focused on human-host attributes such as Glucosyltransferase B [23], antimicrobial peptides [24], past caries experience [25], soluble CD14 [26] and trace elements [27], while only a few have exploited individual microbial features, such as specific microbiological counts [28] and microbial nitrate reductase activities [29]. Few global functional analysis and comparison of saliva microbiota function was available, due to (i) the organismal complexity of the microbiota [9] and (ii) the observations that metagenome-sequencing based functional comparison of microbiota can be hampered by sequencing biases [30], the paucity of reference genomes and the small percentage of annotatable reads [31], [32].…”

Section: Discussionmentioning

confidence: 99%

Saliva Microbiota Carry Caries-Specific Functional Gene Signatures

et al. 2014

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Human saliva microbiota is phylogenetically divergent among host individuals yet their roles in health and disease are poorly appreciated. We employed a microbial functional gene microarray, HuMiChip 1.0, to reconstruct the global functional profiles of human saliva microbiota from ten healthy and ten caries-active adults. Saliva microbiota in the pilot population featured a vast diversity of functional genes. No significant distinction in gene number or diversity indices was observed between healthy and caries-active microbiota. However, co-presence network analysis of functional genes revealed that caries-active microbiota was more divergent in non-core genes than healthy microbiota, despite both groups exhibited a similar degree of conservation at their respective core genes. Furthermore, functional gene structure of saliva microbiota could potentially distinguish caries-active patients from healthy hosts. Microbial functions such as Diaminopimelate epimerase, Prephenate dehydrogenase, Pyruvate-formate lyase and N-acetylmuramoyl-L-alanine amidase were significantly linked to caries. Therefore, saliva microbiota carried disease-associated functional signatures, which could be potentially exploited for caries diagnosis.

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Section: Discussionmentioning

confidence: 99%

Saliva Microbiota Carry Caries-Specific Functional Gene Signatures

et al. 2014

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“…Table (5) shows the differences in salivary total protein and salivary superoxide dismutase between the cariesfree and caries-active groups (DS groups).…”

Section: Resultsmentioning

confidence: 99%

“…According to a study, caries-affected children's salivary total antioxidant capacity increased as compared to caries-free children (4) . Many studies have shown that there are no significant variations in total protein and salivary total antioxidant levels between children with caries and children who do not have caries, regardless of age or gender, with little information about their effects on antioxidants (5,6) .…”

Section: Introductionmentioning

confidence: 99%

Salivary antioxidents in relation to caries severity among a group of young adults

Faris Abdel Aziz,

Ali Jasim

2023

MDJ

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Background: Saliva represents the body's stages of toxicological, hormonal, immunological, and markers of many infectious disease and disorders, so that it's an ideal tool for monitoring oral and systemic health. Antioxidants help the body's defensive system by reducing oxidative stress. Aims of the study: The study was directed to estimate the carious lesion experience (DMFS) in relation to salivary superoxide dismutase and total protein among adults by age and gender. Materials and methods: Caries experiences was assessed according to DMFS index, after investigation eighty peoples of an age 19-22 years for both genders. Stimulated salivary samples were together and chemically assessed to detect selected salivary antioxidants (superoxide dismutase, total protein), under standardized condition. Total protein and superoxide dismutase were measured by spectrophotometric examination. Results: With not-significant differences, total protein was found to be higher in the caries active group than in the caries free group, but salivary superoxide dismutase was the opposite. with statistically not-significant differences, females had a greater average of the salivary total protein than men, whereas men had a greater average of salivary superoxide dismutase than females. the first group (19-20 years) had a not-significant greater average salivary total protein and salivary superoxide dismutase than the second group (21-22 years). Conclusion: Salivary superoxide dismutase is the important factor in dental caries prevention. As a result, alterations in salivary content are crucial in the development and progression of dental caries.

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Speichel als Matrix für das Humanbiomonitoring in der Arbeits‐ und Umweltmedizin [Biomonitoring Methods in German Language, 2015]

Michalke

Roßbach

Göen

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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Saliva as a matrix for human biomonitoring in occupational and environmental medicine Purpose : Human biomonitoring (HBM) implies the assessment of internal exposure to hazardous substances by measuring the substances, their metabolites or reaction products, as well as effect parameters in human body fluids. Along with blood, plasma and urine, saliva is of increasing interest as an alternative matrix for HBM. Methods : This paper reviews studies that measure salivary background levels of hazardous substances, elevated levels after environmental or occupational exposure, as well as references which deal with physiological and toxicokinetic behaviour of saliva and salivary parameters, respectively. Results : The studies revealed that the determination of biomarkers in saliva is a promising approach for HBM, even if only few substances showed a satisfying correlation with exposure data or established biomonitoring matrices such as blood, plasma and urine. Saliva has been proven to be particularly suitable for substances of low molecular weight such as organic solvents, selected pesticides, cotinine, and for some specific trace elements. Besides several advantages, serious problems and limitations were identified. Above all, the complex interactions between substance properties, sampling procedure, sample preparation, measurement techniques or individual factors, and the salivary analyte level are discussed. Conclusions : A major conclusion of the review is that more scientific studies are needed in order to systematically collect data on parameters, influencing salivary analyte levels. Crucially required is a harmonisation of the sampling as well as the sample preparation techniques and procedures, which is indispensable to achieve an overall comparability and interpretability of salivary biomarker levels.

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Study of trace elements in mixed saliva of caries free and caries active children

Cited by 23 publications

References 0 publications

Saliva Microbiota Carry Caries-Specific Functional Gene Signatures

Saliva Microbiota Carry Caries-Specific Functional Gene Signatures

Salivary antioxidents in relation to caries severity among a group of young adults

Speichel als Matrix für das Humanbiomonitoring in der Arbeits‐ und Umweltmedizin [Biomonitoring Methods in German Language, 2015]

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