Study of various biochemical parameter on atrazine induced glucose-6-phosphate dehydrogenase deficiency in brain

Abstract

G6PD is rate limiting enzyme in pentose phosphate pathway (PPP), have effective physiological role in supply of NADPH by converting it into Glucose-6-phosphate to phospogluconate which acts as a major cell reductant and useful to cell survival. Brain is highly sophisticated organ of our body which requires continuous supply of energy in form of glucose. Daily requirement of brain glucose is 120gm. G6PD plays a key role in it. According to WHO 75% of world population have more than one gene for G6PD and around 2.9% of population is G6PD deficient. It is most common enzymatic disorder of cell effecting 200-400 million people. G6PD exist in all cell to oxidative damage and it is responsible for various neurodegenerative disorder like Parkinson’s disease, Alzheimer’s, Schizophrenia catatonia, Neuronal toxicity etc. The research work was aimed to check the neuroprotective potential of Melatonin with Primaquine and Melatonin with Aspirin (contraindicated to G6PD deficient individuals) in Atrazine induced G6PD deficiency in Albino Rats. Study was carried out for the various biochemical parameters (G6PD, Nitrites, LDH, Glucose), neurotransmitters (Serotonin, Dopamine, Nor-adrenaline), anti-oxidant activity (GSH, LPO, SOD and Catalase) and histopathological evaluation.