Study of Various Hematological Parameters and Iron Status among Voluntary Blood Donors

Tailor, Hemali J.; Patel, Prashant; Pandya, Amrish Kumar Narhari Prasad; Mangukiya, Sarita

doi:10.5530/ijmedph.2017.1.11

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…However, Hb levels remain normal till overt iron deficiency anaemia ensues [14]. ensues with an increased donation frequency of 4-5 blood units annually [16]. Our data mimic the results in the RISE study where the authors found previous donation intensity and shorter intervals between whole blood donations as important predictors of absent iron stores and iron-deficient erythropoiesis at enrolment and subsequent visits [12].…”

Section: Discussionsupporting

confidence: 84%

“…The primary reason for the decrease in serum ferritin with increasing donation frequency is that the body demand for iron increases with repeated blood donations at shorter intervals. Though the rate of iron absorption is increased among blood donors still the amount of lost iron cannot be recovered fully by diet alone and therefore iron deficiency ensues with an increased donation frequency of 4–5 blood units annually [16]. Our data mimic the results in the RISE study where the authors found previous donation intensity and shorter intervals between whole blood donations as important predictors of absent iron stores and iron‐deficient erythropoiesis at enrolment and subsequent visits [12].…”

Section: Discussionsupporting

confidence: 67%

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Utility of reticulocyte haemoglobin content and immature reticulocyte fraction in early diagnosis of latent iron deficiency in whole blood donors

et al. 2021

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Background and Objectives: The present study was planned to assess the clinical utility of reticulocyte haemoglobin content (CHr) and immature reticulocyte fraction (IRF) in the early detection of latent iron deficiency in blood donors. Materials and Methods:The prospective longitudinal observational study was conducted using the purposive sampling method. Written informed consent was obtained and donors were allocated into the first-time (FTD) and regular donor (RD) group. The enrolled blood donors (n = 205 in each group) were followed up for two subsequent whole blood donations. Haemoglobin (Hb), CHr, IRF and serum ferritin values were recorded at enrolment and two follow-ups. Results:The sensitivity of CHr in detecting iron-deficient erythropoiesis (serum ferritin values ≤ 26 μg/dl) was 45% and 56.7%, specificity 96.7%, positive predictive value (PPV) 85.6% and 90.8% and negative predictive value (NPV) 80.1% and 78.7%, respectively in FTD and RD cohorts. The sensitivity of IRF was 45.1% and 44.8%, specificity 93.4% and 97.1%, PPV 74.8% and 90.4% and NPV 79.6% and 74.5%, respectively in both the cohorts.The sensitivity of CHr in detecting absent iron stores (serum ferritin values ≤ 15 μg/ dl) was 66.2% and 74.4%, specificity 92% and 90.6%, PPV 56.7% and 68.7% and NPV 94.5% and 92.8% among FTD and RD cohort, respectively. The sensitivity of IRF was 72.7% and 65.3%, specificity 90.3% and 94.3%, PPV 54.4% and 76% and NPV 95.4% and 90.8%, respectively in both the cohorts. Conclusion:Reticulocyte hemoglobin content and IRF can be used along with complete blood count for early detection of iron deficiency in blood donors using the same blood sample at no extra cost.immature reticulocyte fraction, latent iron deficiency, reticulocyte haemoglobin content Highlights• Reticulocyte hemoglobin content and immature reticulocyte fraction were found to have a high positive predictive value and negative predictive value in detecting iron deficiency in whole blood donors at an early stage.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 67%

Utility of reticulocyte haemoglobin content and immature reticulocyte fraction in early diagnosis of latent iron deficiency in whole blood donors

et al. 2021

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“…This is shown by works published by researcher such as Güre et al, (2018); Melian-Alzola & Martin-Santana (2020). Without donated blood, NBSZ, like any blood service, cannot survive (Tailor et al, 2017). There are no perfect substitutes for blood up to date and donating blood is the only solution available to save the lives of millions of patients worldwide.…”

Section: Justification Of This Studymentioning

confidence: 99%

Assessment of Donor Service Quality at National Blood Service Zimbabwe Using Servqual Instrument

Kafere¹,

Garad²

2020

IJQR

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“…Mostly the hemoglobin (Hb) concentration is the main concern. But serum ferritin estimation is rather more important in estimation of iron deficiency anemia in donors as even with reduced iron stores the value of hemoglobin concentration might be normal 5,6,7 One blood donation depletes 4 to 10 percent of body iron and fall in hemoglobin concentration. Short intervals between the blood donations increase the chances of iron depletion; however, the long intervals between the donations are at lower risk of iron deficiency anemia 7,8,9 .…”

Section: Introductionmentioning

confidence: 99%

To Assess the Iron Reserves in Blood Donors by Measuring Serum Ferritin and Hemoglobin in the Children Hospital Lahore

Fateen¹,

Ali²,

Saqlain³

et al. 2022

PJMHS

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Introduction: Frequent contribution of blood can cause iron exhaustion in blood donors along with the problems related to it. Curtailing the proportion of iron reduction among blood donors is a crucial plan for boosting donor’s well-being. Aim & objectives: The aim of this analysis is to determine iron stocks by measuring serum ferritin in pre-donation male blood donors along with their relation with the hemoglobin concentration and frequency of blood donations. Study design: Cross-sectional study. Place and duration: Pathology (immunohematology) department and blood bank of University of Child Health Sciences, The Children Hospital Lahore from Aug 2021 to July 2022 Material and Methods: A total of 350 serum samples were processed to determine hemoglobin and serum ferritin concentrations. The study involved was performed on healthy blood donors. The method used was chemiluminescence for the simultaneous measurement of serum ferritin. Results: An aggregate of 350 serums were collected from the contributors in blood bank. Among them, 154 were the first-time donor and 196 were the frequent donors; the serum ferritin was markedly reduced in constant contributors. The mean value 105ng/mL was found in infrequent donors and 79.35ng/mL was found in frequent donors. There was no notable variance in hemoglobin of newbie and regular blood givers. However, a momentous variation in the pervasiveness of iron depletion between first‑time and regular donors is found. Conclusion: Blood donation has a noteworthy impact on iron stores and is one of the most important factors for iron shortage in contributors, specifically in those who donate blood again and again. Serum ferritin measurement ought to be incorporated in the blood donor preference especially in the evaluation of consistent blood givers to assure enough iron pools in the donor community in order to sustain a pertinent potential donor.

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Study of Various Hematological Parameters and Iron Status among Voluntary Blood Donors

Cited by 12 publications

References 15 publications

Utility of reticulocyte haemoglobin content and immature reticulocyte fraction in early diagnosis of latent iron deficiency in whole blood donors

Utility of reticulocyte haemoglobin content and immature reticulocyte fraction in early diagnosis of latent iron deficiency in whole blood donors

Assessment of Donor Service Quality at National Blood Service Zimbabwe Using Servqual Instrument

To Assess the Iron Reserves in Blood Donors by Measuring Serum Ferritin and Hemoglobin in the Children Hospital Lahore

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