Study of versatile coordination modes, antibacterial and radical scavenging activities of arene ruthenium, rhodium and iridium complexes containing fluorenone based thiosemicarbazones

Nongpiur, Carley Giffert L.; Ghate, Mayur Mohan; Tripathi, Dulal Krishna; Poluri, Krishna Mohan; Kaminsky, Werner; Kollipara, Mohan Rao

doi:10.1016/j.jorganchem.2021.122148

Cited by 19 publications

(8 citation statements)

References 50 publications

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“…1 Till now, the majority of reports about Sm(III) complexes and their biomedical applications are in the bulk state. [24][25][26][27][28][29] The reports about the incorporation of Sm(III) complexes into polymeric nanobers are, however, limited. Therefore, an essential goal of the present study is the fabrication of a drug delivery system by preparation of electrospinning bers (as a biocompatible drug carrier) with loading Sm(III) nanocomplex, their antitumor activities were evaluated both in vitro on tumor cell lines and in vivo on tumor-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Fouad

Ali

2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Fouad

Ali

2023

RSC Adv.

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“…A borer was used to make five 0.6 cm wells in each plate, and 50 μL of prepared latex samples and control medications were placed into the relevant plate wells, along with 50 μL of DMSO in the middle well as a control blank. The bacterial plates were incubated at 37 °C for 24 h, and the fungal plates at 25 °C for 72 h. Later, the zone of inhibition was measured in millimeters (mm). , …”

Section: Materials and Methodsmentioning

confidence: 99%

“…The bacterial plates were incubated at 37 °C for 24 h, and the fungal plates at 25 °C for 72 h. Later, the zone of inhibition was measured in millimeters (mm). 24,25 3. RESULTS…”

Section: Agar Plate Diffusion Assaymentioning

confidence: 99%

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Kumar R,

Gosipatala,

Kumar

et al. 2023

ACS Omega

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In order to find the most advantageous bioactive compounds from mulberry latex for drug development in the near future, this study was conducted to characterize and evaluate antioxidant and antimicrobial properties from four different mulberry lattices (BR-2, S-1, AR-14, and S-146). The characterization of the lattices was performed by scanning electron microscopy with energy-dispersive X-ray spectroscopy, gas chromatography coupled to mass spectroscopy, and Fourier transform infrared spectroscopy. Further, screenings of the antioxidant and antimicrobial potential of selected lattices were performed in vitro using 2,2-diphenyl-1-picrylhydrazyl assay and agar well diffusion methods, respectively. Interestingly, the outcome of the current study revealed that tested mulberry lattices contain a considerable amount of bioactive phytoconstituents, particularly antimicrobial and antioxidant compounds, as revealed by chromatographic analysis. BR-2 latex was found to have significant antioxidant activity (75%) followed by S-146 (64.6%) and AR-14 (52.9%). The maximum antimicrobial activity was found in BR-2 latex compared to other tested latex varieties. The results of this investigation showed that mulberry latex from the BR-2 type may successfully control both bacterial and fungal infections, with the added benefit of having enhanced antioxidant capabilities.

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“…[8,9] Additionally, the hypothesized unique mechanism of action (MoA) of organometallic complexes, integrated with the generation of reactive oxygen species (ROS) due to their variable oxidation states and, for instance, interactions with various biomolecules, such as, DNA as well as the slow rate of ligand exchange is another tremendous advantage to consider them for further studies. [9][10][11][12][13][14][15] As mentioned earlier, the selection of the most suitable ligands to improve the overall efficiency of metal-based compounds is very important. Therefore, the application of alkaloids, which are mostly produced by plants, is implied by affiliation to their membership in a family with diverse biological and pharmaceutical properties.…”

Section: Introductionmentioning

confidence: 99%

Antibactericidal Ir(III) and Ru(II) Complexes with Phosphine‐Alkaloid Conjugate and Their Interactions with Biomolecules: A Case of N‐Methylphenethylamine

Wojtala

Kozieł

Witwicki

et al. 2023

Chemistry A European J

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The phosphine ligand (Ph2PCH2N(CH3)(CH2)2Ph, PNMPEA) obtained by the reaction of the (hydroxymethyl)diphenylphosphine with naturally occurring alkaloid N‐methylphenethylamine, was used to synthesize the half‐sandwich iridium(III) (Ir(η5‐Cp*)Cl2Ph2PCH2N(CH3)(CH2)2Ph, IrPNMPEA) and ruthenium(II) (Ru(η6‐p‐cymene)Cl2Ph2PCH2N(CH3)(CH2)2Ph, RuPNMPEA) complexes. They were characterized using a vast array of methods, including 1D and 2D NMR, ESI(+)MS spectrometry, elemental analysis, cyclic voltammetry (CV), electron spectroscopy in the UV‐Vis range (absorption, fluorescence) and density functional theory (DFT). The initial antimicrobial activity in vitro toward Gram‐positive and Gram‐negative bacterial strains was examined, indicating that both complexes are selective towards Gram‐positive bacteria, e.g., Staphylococcus aureus, where the IrPNMPEA has been more bactericidal compared to RuPNMPEA. Additionally, the interactions of these compounds with various biomolecules, such as DNA (ctDNA, plasmid DNA, 9‐ethylguanine (9‐EtG), and 9‐methyladenine (9‐MeA)), nicotinamide adenine dinucleotide (NADH), glutathione (GSH), and ascorbic acid (Asc) were described. The results showed that both Ir(III) and Ru(II) complexes accelerate the oxidation process of NADH, GSH and Asc that appeared to occur by an electron transfer mechanism. Interestingly, only IrPNMPEA leads to the formation of various biomolecule adducts, which can explain its higher activity. Furthermore, RuPNMPEA and IrPNMPEA have been interacting with the DNA through weak noncovalent interactions.

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Study of versatile coordination modes, antibacterial and radical scavenging activities of arene ruthenium, rhodium and iridium complexes containing fluorenone based thiosemicarbazones

Cited by 19 publications

References 50 publications

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Novel electrospun fibers as carriers for delivering a biocompatible Sm(iii) nanodrug for cancer therapy: fabrication, characterization, cytotoxicity and toxicity

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Antibactericidal Ir(III) and Ru(II) Complexes with Phosphine‐Alkaloid Conjugate and Their Interactions with Biomolecules: A Case of N‐Methylphenethylamine

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