Study of vortex-assisted MSPD and LC-MS/MS using alternative solid supports for pharmaceutical extraction from marketed fish

Abstract

A procedure based on vortex-assisted matrix solid-phase dispersion (MSPD) for the extraction of 15 pharmaceuticals from fish samples with determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was validated. Florisil, C18, diatomaceous earth, chitin, and chitosan were evaluated as solid supports. Best results were obtained with 0.5 g of diatomaceous earth, 0.5 g of sodium sulfate, and 5 mL of methanol. Analytical recoveries ranged from 58 to 128 % with relative standard deviation (RSD) lower than 15 %. Limit of quantification (LOQ) values for the 15 compounds ranged from 5 to 1000 ng g(-1). The method under investigation has shown to be a simple and fast extraction tool with minimum instrumentation and low amount of reagent, resulting in method low cost. Besides, alternative materials, such as chitin and chitosan, which were applied to the dispersion step for the first time, were found to be interesting alternatives.

Optimization of double-vortex-assisted matrix solid-phase dispersion for the rapid determination of paraben preservative residues in leafy vegetables

“…Based on previous studies and our experiences involving indoor dust and biota sample pretreatment using various MSPD techniques, C18, PSA and HLB sorbents have shown good extraction efficiency for polar and hydroxylated micropollutants when used as dispersant/clean-up cosorbent. [13][14][15][16][17] Either methanol or acetonitrile was commonly used as the extracting solvent, and either vortex or ultrasonic was oen employed as an extraction mechanic force to increase the extraction efficiency. 8,10,13,14,16,22 To select the signicant type of variables as listed above (also shown in Table 2), a FMLCD with 2 or 3 non-numeric variables was rst applied for selecting the most signicant factors.…”

“…Vortex-assisted MSPD (VA-MSPD) was rst reported by Primel's group, the method that replaced the SPE-column by vortex agitation to eliminate the need for SPE-column packing and elution. 16,17 The second simplied approach, known as vortexhomogenized MSPD (VH-MSPD), also utilizes vortex agitation to replace the use of a mortar and pestle for sample homogenization and blending. 18,19 VH-MSPD can be used to homogenize and blend up to six samples at one time, without the time-consuming steps of cleaning the mortar and pestle between each sample preparation.…”

Cucurbituril and zwitterionic surfactant‐based matrix solid‐phase dispersion microextraction to simultaneously determine terpenoids from Radix Curcumae

“…Due to these potential traits, many modified MSPD methods have been widely applied in the determination of additives and pesticide residues in food [13–16], extraction of active compounds in herbal medicine [17–20], detection of dust in the air [21], etc. Various types of solid supports were employed in the literature, including florisil, C 18 , graphene, and silica gel [22–24]. However, cucurbituril was excluded, which has never been used as an adsorbent in MSPD microextraction till now.…”

New Vortex-Synchronized Matrix Solid-Phase Dispersion Method for Simultaneous Determination of Four Anthraquinones in Cassiae Semen

“…Therefore, VS-MSPD technique based on a matrix solid phase dispersion by using vortex agitation instead of the solid phase extraction step, seems to be a good choice. Several studies have shown that it leads to acceptable results with the advantage of high speed, simplicity, and a low cost material in complex matrices [26,27,28,29,30,31,32].…”