Study on a novel poly (vinyl alcohol)/graphene oxide-citicoline sodium-lanthanum wound dressing: Biocompatibility, bioactivity, antimicrobial activity, and wound healing effect

Liu, Yihan; Zhang, Qicheng; Zhou, Ninglin; Tan, Jingting; Ashley, Jon; Wang, Wentao; Wu, Fan; Shen, Jian; Zhang, Ming

doi:10.1016/j.cej.2020.125059

Cited by 57 publications

(23 citation statements)

References 60 publications

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“…Li et al [ 73 ] used the antioxidant N-acetylcysteine (NAC) to load GO for sustained release and combined with type I collagen (Col) to prepare the composite film, which can continuously release the antioxidant NAC and have better mechanical properties and stronger water retention, to obtain the hybrid film for skin regeneration without a scar. Liu et al [ 74 ]prepared polyvinyl alcohol/graphene oxide-citicoline sodium-lanthanum (PVA/GO-CDPC-La) film by solution intercalation method ( Figure 8 ), which modified GO by antibacterial CDPC to improve the dispersion of water-based polymers while providing more adsorption sites for La 3+ ions and enhancing the antibacterial properties of the membrane, which can significantly reduce the risk of wound infection. Jian et al [ 75 ] made their antibacterial agent polyhexamethylene guanidine hydrochloride (PHMG) grafted GO (MGO) and introduced it into the bilayer thermoplastic polyurethane TPU composite porous membrane.…”

Section: Applications Of Gbns In Soft Tissue Engineeringmentioning

confidence: 99%

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Chen

Weng

2022

Materials

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Over the last few decades, tissue engineering has become an important technology for repairing and rebuilding damaged tissues and organs. The scaffold plays an important role and has become a hot pot in the field of tissue engineering. It has sufficient mechanical and biochemical properties and simulates the structure and function of natural tissue to promote the growth of cells inward. Therefore, graphene-based nanomaterials (GBNs), such as graphene and graphene oxide (GO), have attracted wide attention in the field of biomedical tissue engineering because of their unique structure, large specific surface area, good photo-thermal effect, pH response and broad-spectrum antibacterial properties. In this review, the structure and properties of typical GBNs are summarized, the progress made in the development of GBNs in soft tissue engineering (including skin, muscle, nerve and blood vessel) are highlighted, the challenges and prospects of the application of GBNs in soft tissue engineering have prospected.

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Section: Applications Of Gbns In Soft Tissue Engineeringmentioning

confidence: 99%

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Chen

Weng

2022

Materials

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“…52 After adding GO in the DCSG/GO cryogel scaffolds, the antibacterial activity was slightly enhanced, which was ascribed to the direct contact between bacteria and the sharp edges of GO and consequently penetrate through the cell membrane to kill the bacteria. 53,54 However, the antibacterial ability was still limited and exhibited a relatively high bacterial survival rate. For the NIR treatment group, the antibacterial activity was enhanced with the increasing contents of GO.…”

Section: Photothermal Performance and Antimicrobial Activity Of Dcsmentioning

confidence: 99%

N‐dodecylated chitosan/graphene oxide composite cryogel for hemostasis and antibacterial treatment

Qiu

Dong

Zhao

et al. 2021

J of Applied Polymer Sci

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Uncontrolled massive bleeding remains a global issue, which requires an exigent response for safe and efficient hemostat. However, most of hemostats without antimicrobial property could trigger serious bacterial infection problem. Herein, a composite cryogel was synthesized by double bond N-dodecylated chitosan (DCSG) and graphene oxide (GO). The cryogel (DCSG/GO) with macroporous structure exhibited high-fluid adsorption ability, excellent mechanical property, and fluid-triggered shape recovery performance. Moreover, the in vitro blood coagulation experiments proved that DCSG/ GO 5% possessed better coagulation efficiency than medical gelatin sponge. And the DCSG/GO 5% cryogel exhibited more erythrocyte and platelets activation. Besides, the cryogel had excellent near-infrared (NIR)-assisted photothermal antibacterial activity against both Escherichia coli and Staphylococcus aureus and killed 99% of them after 20 min NIR irradiation. In addition, the vitro hemolysis and cytotoxicity results proved the well biocompatibility of cryogel. Therefore, the biocompatible DCSG/GO cryogel has great potential application prospect in clinical hemorrhage control and anti-infection treatment.

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“…[1] As one of the largest organs of the human body, [2] Skin covers the entire body surface and is vulnerable to external hurt. [3] If properties are greatly restricted in the context of biology and cell mechanics, and it is difficult to create a solid polymer film network with long-term durability. [13] How to control its microstructure, mechanical strength and other performance parameters to optimize tissue regeneration is still facing huge challenges.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Polyvinyl Alcohol/ Lauramidopropyl Betaine/2D‐HOF Mixed Film with Abundant Hydrogen Bonds Acts as High Mechanical Strength Artificial Skin

Chen

Zhang

et al. 2021

Macromolecular Bioscience

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The mechanical properties of artificial skins are complicated to maintain under ensuring air permeability and antimicrobial. Thus, a series of hydrophilic antimicrobial polymer networks are prepared by crosslinking chitosan and polyvinyl alcohol with the lauramidopropyl betaine and hydrogen bond organic framework (CS/PVA/LPB/2D-HOF). The mechanical performance of the control groups and the complex are systematically evaluated to attain an artificial strength skin. The CS/PVA/LPB/2D-HOF complex exhibits strong mechanical abilities than other control groups. By analyzing the IR spectra and the morphology, the synergistic effect of hydrogen bonds between molecules and cracks significantly improves the mechanical properties of the complex. Its maximum tensile strength can reach 29 MPa, and its maximum load capacity can reach 3700 g. Notably, the composite membrane also performs an excellent antimicrobial activity. In vivo and in vitro experiments show that the hybrid membrane can promote tissue regeneration and wound healing (95%). These results may open up the opportunity for future composite material investigations in the artificial skin and tissue engineering field.

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Study on a novel poly (vinyl alcohol)/graphene oxide-citicoline sodium-lanthanum wound dressing: Biocompatibility, bioactivity, antimicrobial activity, and wound healing effect

Cited by 57 publications

References 60 publications

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

Progress in the Development of Graphene-Based Biomaterials for Tissue Engineering and Regeneration

N‐dodecylated chitosan/graphene oxide composite cryogel for hemostasis and antibacterial treatment

Chitosan/Polyvinyl Alcohol/ Lauramidopropyl Betaine/2D‐HOF Mixed Film with Abundant Hydrogen Bonds Acts as High Mechanical Strength Artificial Skin

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