Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil

Wang, Wenting; Li, Dongxiang; Huang, Xiaoqin; Yang, Huixiang; Qiu, Ziwen; Zou, Liting; Qin, Liang; Shi, Yu; Wu, Yingxiang; Wu, Shao‐Hua; Yang, Chao; Li, Yongyu

doi:10.3390/molecules24203792

Cited by 54 publications

(39 citation statements)

References 44 publications

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“…ZN2 reduced the production of EPS by 41–85% as well as the motility of P. aeruginosa PAO1 by 28–89% ( Figure 4 C). Various plant extracts such as Cuminum cyminum , 71 Mangifera indica , 72 Alpinia officinarum, 70 and Cinnamomum tamala ( 70 ) as well as secondary metabolites, 73 , 74 green tea, 75 and essential oils 67 , 76 have been reported to hinder the swarming motility of P. aeruginosa PAO1. However, there are limited studies that have evaluated the effect of metal NPs on the attenuation of swarming motility.…”

Section: Resultsmentioning

confidence: 99%

Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes

et al. 2020

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This study evaluates the impact of two separate incubation periods (4 and 6 weeks) on the morphology of sol–gel-fabricated ZnO nanospikes (ZNs), that is, ZN1 and ZN2, respectively. We further analyzed the inhibitory effects of ZN1 and ZN2 on quorum sensing (QS) and biofilm formation in Pseudomonas aeruginosa (PAO1) and Chromobacterium violaceum (strains 12472 and CVO26). The size of the synthesized ZNs was in the range of 40–130 nm, and finer nanoparticles were synthesized after an incubation period of 6 weeks. Treatment with ZNs decreased the production of violacein in the pathogen without affecting the bacterial growth, which indicated that ZNs inhibited the QS signaling regulated by N -acyl homoserine lactone. ZN2 had a higher inhibitory action on the virulence factor productivity than ZN1. Furthermore, ZN2-treated cells displayed a substantial decrease in azocasein-degrading protease activity (80%), elastase activity (83%), and pyocyanin production (85%) relative to untreated P. aeruginosa PAO1 cells. Treatment with ZN2 decreased swarming motility and exopolysaccharide production by 89 and 85%, respectively. ZN2 was effective against both the las & pqs systems of P. aeruginosa and exhibited broad-spectrum activity. Additionally, ZN2 was more efficient in inhibiting the biofilm formation at the attachment stage than ZN1. These findings revealed that in P. aeruginosa , ZN2 demonstrated inhibitory effects on QS as well as on the development of biofilms. Thus, ZN2 can be potentially used to treat drug-resistant P. aeruginosa infections.

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Section: Resultsmentioning

confidence: 99%

Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes

et al. 2020

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“…The emergence of multidrug-resistant microbial pathogens, usually resulting from misuse of conventional antibiotics, has caused an elapse in their efficacy, and researchers are turning towards the search for novel antimicrobial agents [ 17 , 51 ]. It is very important to search for new therapies, and an appropriate strategy seems to be the disruption of bacterial cell-to-cell communication networks, known as quorum sensing (QS), the inhibition of microbial biofilms as well as motilities [ 52 , 53 ]. Propolis is a safe and natural antimicrobial, which could be an alternative to antibiotics.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study of Chemical Profiles of Honey, Cerumen, and Propolis of the African Stingless Bee Meliponula ferruginea

Popova

Gerginova

Trusheva

et al. 2021

Foods

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Recently, the honey and propolis of stingless bees have been attracting growing attention because of their health-promoting properties. However, studies on these products of African Meliponini are still very scarce. In this preliminary study, we analyzed the chemical composition of honey, two cerumen, and two resin deposits (propolis) samples of Meliponula ferruginea from Tanzania. The honey of M. ferruginea was profiled by NMR and indicated different long-term stability from Apis mellifera European (Bulgarian) honey. It differed significantly in sugar and organic acids content and had a very high amount of the disaccharide trehalulose, known for its bioactivities. We suggested trehalulose to be a potential marker for African stingless bee honey analogously to the recent proposal for Meliponini honey from Asia, South America, and Australia and demonstrated its easy discrimination by 13C NMR. Propolis and cerumen were studied by GC-MS (gas chromatography-mass spectometry). The samples contained mainly terpenoids (di-and triterpenes) but demonstrated qualitative and quantitative differences. This fact was an indication that possibly M. ferruginea has no strict preferences for resins used to construct and protect their nests. The antimicrobial and anti-quorum sensing properties of the two materials were also tested. These first results demonstrated that the honey, cerumen, and propolis of African stingless bees were rich in biologically active substances and deserved further research.

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“…Moreover, considering the antibacterial potential of essential oilss, a previous study on C. camphora reported that the leaf essential oilfrom China is a good antibacterial agent, exhibiting a wide range of antibacterial activities against common bacteria, e.g., Chromobacterium violaceum , Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa [ 55 ]. These authors also investigated the anti-quorum sensing (anti-QS) inhibitory activity of the EO.…”

Section: Discussionmentioning

confidence: 99%

Sub-Tissue Localization of Phytochemicals in Cinnamomum camphora (L.) J. Presl. Growing in Northern Italy

Bottoni

Milani

Mozzo

et al. 2021

Plants

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In the present paper, we focused our attention on Cinnamomum camphora (L.) J. Presl. (Lauraceae), studied at three levels: (i) micromorphological, with the analysis of the secretory structures and a novel in-depth histochemical characterization of the secreted compounds; (ii) phytochemical, with the characterization of the essential oils from young stems, fruits, and leaves, subjected to different conservation procedures (fresh, dried, stored at −20 °C, stored at −80 °C) and collected in two different years; (iii) bioactive, consisting of a study of the potential antibacterial activity of the essential oils. The micromorphological investigation proved the presence of secretory cells characterized by a multi-layered wall in the young stems and leaves. They resulted in two different types: mucilage cells producing muco-polysaccharides and oil cells with an exclusive terpene production. The phytochemical investigations showed a predominance of monoterpenes over sesquiterpene derivatives; among them, the main components retrieved in all samples were 1,8-cineole followed by α-terpineol and sabinene. Conservation procedures seem to only influence the amounts of specific components, i.e., 1,8-cineole and α-terpineol, while analyses on each plant part revealed the presence of some peculiar secondary constituents for each of them. Finally, the evaluation of the antibacterial activity of the essential oil showed a promising activity against various microorganisms, as Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa. In conclusion, we combined a micromorphological and phytochemical approach of the study on different plant parts of C. camphora, linking the occurrence of secretory cells to the production of essential oils. We compared, for the first time, the composition of essential oils derived from different plant matrices conserved with different procedures, allowing us to highlight a relation between the conservation technique and the main components of the profiles. Moreover, the preliminary antibacterial studies evidenced the potential activity of the essential oils against various microorganisms potentially dangerous for plants and humans.

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Study on Antibacterial and Quorum-Sensing Inhibition Activities of Cinnamomum camphora Leaf Essential Oil

Cited by 54 publications

References 44 publications

Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes

Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes

A Preliminary Study of Chemical Profiles of Honey, Cerumen, and Propolis of the African Stingless Bee Meliponula ferruginea

Sub-Tissue Localization of Phytochemicals in Cinnamomum camphora (L.) J. Presl. Growing in Northern Italy

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