Study on antimicrobial and antioxidant potentials of <i>Alchornea cordifolia</i> (Linn.): an <i>in vitro</i> assessment

Ajayi, Oludare Femi; Olasunkanmi, Oluwaseun Oyetunji; Agunbiade, Mayowa Oladele; Alayande, Kazeem Adekunle; Aiyegoro, Olayinka Ayobami; Akinpelu, David A.

doi:10.1080/0035919x.2020.1830868

Cited by 1 publication

(1 citation statement)

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“…Several healthy matured thick leaves of the Aloe plant were plucked from the stem and allowed to drain its fresh yellow latex for a period of 30 min into a sterile container. The latex was sterilized by steaming at 65°C for 15 min [17].…”

Section: Preparation Of Leaf Latexmentioning

confidence: 99%

Antibacterial kinetics and phylogenetic analysis of Aloe vera plants

Akinduti

Obafemi

Isibor

et al. 2021

Open Access Maced J Med Sci

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Uncontrolled use of antibiotics has resulted in the emergence of resistant bacteria. It has necessitated the evaluation of antibacterial activities and phylo-diversity of Aloe vera (also called Aloe barbadensis) plants as antimicrobial agent in Nigeria. Biotyped enteric bacilli of 251 strains obtained from fecal samples of patients with various gastro-intestinal complications are profiled for antibiogram. Resistant biotypes were assayed for susceptibility to Aloe vera latex and further evaluated for time-kill kinetics and phylo-diversity. More than 30% of enteric bacilli, including Citrobacter freundii, Escherichia coli and Proteus mirabilis were resistant to cotrimoxazole, ciprofloxacin, and tetracycline respectively at MIC >16 µg/ml (p=0.004). Aloe vera latex significantly inhibited 39.5% resistant enteric biotypes with a significant average reduction of the viable count at 1xMIC and 2xMIC to less than 3.0 Log10CFU/mL after 24 hours. Flavonoids, alkaloids, terpenoids and anthraquinine in anti-enteric sap significantly correlated and regressed with antibacterial activity (p<0.05), while two of the antimicrobial Aloe vera plants showed phylogenetic relatedness with other homologous. Anti-bacteria efficacy of some Nigerian Aloe vera latex could provide alternative therapy, while its phylo-diversity and genomic profiling would offer a promising avenue for identification and development of antimicrobial agents as drug candidates for natural antibiotics.

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Section: Preparation Of Leaf Latexmentioning

confidence: 99%